BKMS-react online

Pathways

vitamin B1 metabolism (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

3.5.99.2

aminopyrimidine aminohydrolase

thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate salvage IV (yeast)

: BR49840

: R02133

: THIAMINASE-RXN

natural substrates

2.7.1.50

hydroxyethylthiazole kinase

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate salvage II,
thiamine diphosphate salvage IV (yeast),
thiamine phosphate formation from pyrithiamine and oxythiamine (yeast)

: BR47785

: R04448

: THIAZOLSYN3-RXN

natural substrates

2.2.1.7

1-deoxy-D-xylulose-5-phosphate synthase

pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2

: vitamin B1 metabolism,
isoprenoid biosynthesis

: Thiamine metabolism,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: thiazole component of thiamine diphosphate biosynthesis I,
thiazole component of thiamine diphosphate biosynthesis II,
pyridoxal 5'-phosphate biosynthesis I,
methylerythritol phosphate pathway I,
methylerythritol phosphate pathway II

: BR37092

, BS260856

: R05636

: DXS-RXN

: 5234

natural substrates

2.7.1.49

hydroxymethylpyrimidine kinase

ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II,
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I,
thiamine diphosphate salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine phosphate formation from pyrithiamine and oxythiamine (yeast)

: BR48075

: R04509

: PYRIMSYN3-RXN

natural substrates

2.7.4.7

phosphooxymethylpyrimidine kinase

ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: BR48075

: R04509

: PYRIMSYN3-RXN

natural substrates

4.1.99.17

phosphomethylpyrimidine synthase

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I

: BR49773

: R03472

: PYRIMSYN1-RXN

natural substrates

2.7.1.35

pyridoxal kinase

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine phosphate formation from pyrithiamine and oxythiamine (yeast)

: BR47783

: R03471

: OHMETPYRKIN-RXN

: 3265

natural substrates

2.7.1.49

hydroxymethylpyrimidine kinase

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine phosphate formation from pyrithiamine and oxythiamine (yeast)

: BR47783

: R03471

: OHMETPYRKIN-RXN

: 3265

natural substrates

2.7.4.7

phosphooxymethylpyrimidine kinase

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine phosphate formation from pyrithiamine and oxythiamine (yeast)

: BR47783

: R03471

: OHMETPYRKIN-RXN

: 3265

natural substrates

2.5.1.3

thiamine phosphate synthase

4-amino-2-methyl-5-(diphosphomethyl)pyrimidine + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = diphosphate + thiamine phosphate + CO2

: vitamin B1 metabolism

: thiamine diphosphate biosynthesis I (E. coli)

: BR47665

: R11312

: RXN-12611

: Studies with the enzyme from Bacillus subtilis suggested that the preferred substrate for the enzyme in vivo is CPD-13576 [21534620]. However, the enzyme also accepts |FRAME:THZ-P| with similar efficiency.

natural substrates

2.7.1.89

thiamine kinase

ATP + thiamine = ADP + thiamine phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine diphosphate salvage I

: BR47814

: R02134

: THIKIN-RXN

natural substrates

2.7.1.21

thymidine kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.12

T2-induced deoxynucleotide kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.13

(deoxy)nucleoside-phosphate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.16

thiamine-phosphate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.3

adenylate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.4

nucleoside-phosphate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.8

guanylate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.4.9

dTMP kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622, 91

natural substrates

2.7.6.2

thiamine diphosphokinase

ATP + thiamine = AMP + thiamine diphosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine diphosphate salvage III

: BR47855

: R00619

: THIAMIN-PYROPHOSPHOKINASE-RXN

natural substrates

3.1.3.1

alkaline phosphatase

thiamine phosphate + H2O = thiamine + phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)

: BR51620

: R02135

: RXNQT-4191

natural substrates

3.1.3.100

thiamine phosphate phosphatase

thiamine phosphate + H2O = thiamine + phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)

: BR51620

: R02135

: RXNQT-4191

natural substrates

3.1.3.2

acid phosphatase

thiamine phosphate + H2O = thiamine + phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)

: BR51620

: R02135

: RXNQT-4191

natural substrates

2.4.2.60

cysteine-dependent adenosine diphosphate thiazole synthase

NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O

: vitamin B1 metabolism

: BR52385

n.a.

natural substrates

2.8.1.7

cysteine desulfurase

L-cysteine + [ThiI]-cysteine = L-alanine + [ThiI]-S-sulfanylcysteine

: vitamin B1 metabolism

: BS426551

n.a.

2.7.7.73

sulfur carrier protein ThiS adenylyltransferase

ATP + [ThiS] = diphosphate + adenylyl-[ThiS]

: vitamin B1 metabolism

: thiazole component of thiamine diphosphate biosynthesis I,
thiazole component of thiamine diphosphate biosynthesis II

: BR49425

: RXN-9789

natural substrates, protein

4.1.99.19

2-iminoacetate synthase

L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+

: vitamin B1 metabolism

: thiazole component of thiamine diphosphate biosynthesis I

: BR49775

: RXN-11319

natural substrates

2.8.1.10

thiazole synthase

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O

: vitamin B1 metabolism

: BS416005

natural substrates, protein

2.5.1.3

thiamine phosphate synthase

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)thiazole = diphosphate + thiamine phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: thiamine diphosphate salvage II,
thiamine diphosphate salvage IV (yeast),
thiamine phosphate formation from pyrithiamine and oxythiamine (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)

: BR51526

: R03223

: THI-P-SYN-RXN

: 3049

natural substrates