Print
2-heptyl-3-hydroxy-4(1H)-quinolone synthase
Pathways
tryptophan metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4-quinolone + H2O
; "show the reaction diagram")
-
-
-
: multi-step reactionnatural substrates, multi-step reaction
2-heptyl-4(1H)-quinolone synthase
1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4-quinolone + H2O
-
-
-
: multi-step reactionnatural substrates, multi-step reaction
2-heptyl-4(1H)-quinolone synthase
S-octanoyl-L-cysteinyl-[PqsC protein] + (2-aminobenzoyl)acetate = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]
n.a.
-
-
-
natural substrates
2-heptyl-4(1H)-quinolone synthase
octanoyl-CoA + L-cysteinyl-[PqsC protein] = S-octanoyl-L-cysteinyl-[PqsC protein] + CoA
n.a.
-
-
-
natural substrates
2-aminobenzoylacetyl-CoA thioesterase
(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA
; "show the reaction diagram")
-
-
-
-
natural substrates
3-(aryl)acrylate reductase
3-(1H-indol-3-yl)propanoate + electron-transfer flavoprotein = 3-(indol-3-yl)acrylate + reduced electron-transfer flavoprotein
; "show the reaction diagram")
generic compounds
-
-
-
natural substrates, protein
phenyllactyl-CoA dehydratase
(R)-3-(indol-3-yl)lactoyl-CoA = 3-(indol-3-yl)acryloyl-CoA + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA
; "show the reaction diagram")
-
-
-
-
natural substrates
2-aminobenzoylacetyl-CoA = 4-hydroxy-2(1H)-quinolone + CoA
-
-
-
-
natural substrates
0.0.0.0
spontaneous reaction
2-aminobenzoylacetyl-CoA = 4-hydroxy-2(1H)-quinolone + CoA
-
-
-
-
natural substrates
anthraniloyl-CoA anthraniloyltransferase
S-anthraniloyl-L-cysteinyl-[PqsD protein] + malonyl-CoA = 2-aminobenzoylacetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]
n.a.
-
-
-
natural substrates
tryptophan-phenylpyruvate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
; "show the reaction diagram")
-
-
-
-
natural substrates
branched-chain-amino-acid transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
alanine-glyoxylate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
tyrosine transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
serine-pyruvate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
glutamine-phenylpyruvate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
L-tryptophan-pyruvate aminotransferase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
-
-
-
-
natural substrates
SPONTANEOUS
4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O + H+
; "show the reaction diagram")
-
-
-
: spontaneous the second step of two-step reaction (see R12688, R01956+R03445 / R12692, R01957+R03445): From the comments for EC 2.6.1.7: The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.natural substrates
0.0.0.0
spontaneous reaction
4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O + H+
-
-
-
: spontaneous the second step of two-step reaction (see R12688, R01956+R03445 / R12692, R01957+R03445): From the comments for EC 2.6.1.7: The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.natural substrates
kynurenine-glyoxylate transaminase
4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O + H+
-
-
-
: spontaneous the second step of two-step reaction (see R12688, R01956+R03445 / R12692, R01957+R03445): From the comments for EC 2.6.1.7: The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.natural substrates
kynurenine-oxoglutarate transaminase
4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O + H+
-
-
-
: spontaneous the second step of two-step reaction (see R12688, R01956+R03445 / R12692, R01957+R03445): From the comments for EC 2.6.1.7: The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.natural substrates
anthranilate 3-monooxygenase (FAD)
anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
tryptophan-phenylpyruvate transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
; "show the reaction diagram")
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
-
-
-
-
natural substrates
glutamine-phenylpyruvate transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
-
-
-
-
natural substrates
aspartate-phenylpyruvate transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
-
-
-
-
natural substrates
L-tryptophan-pyruvate aminotransferase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
-
-
-
-
natural substrates
pyruvate decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
; "show the reaction diagram")
-
-
-
-
natural substrates
phenylpyruvate decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
-
-
-
-
natural substrates
branched-chain-2-oxoacid decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
-
-
-
-
natural substrates
indolepyruvate decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
-
-
-
-
natural substrates
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
; "show the reaction diagram")
-
-
-
-
natural substrates
indole-3-acetaldehyde reductase (NADPH)
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
-
-
-
-
natural substrates
alcohol dehydrogenase (NADP+)
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
-
-
-
-
natural substrates
aldose reductase
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
-
-
-
-
natural substrates
xanthine dehydrogenase
indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+
; "show the reaction diagram")
-
-
-
-
natural substrates
aldehyde dehydrogenase (NAD+)
indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+
-
-
-
-
natural substrates
phenylacetaldehyde dehydrogenase
indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+
-
-
-
-
natural substrates
aldehyde dehydrogenase [NAD(P)+]
indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+
-
-
-
-
natural substrates
L-glutamate gamma-semialdehyde dehydrogenase
indole-3-acetaldehyde + NAD+ + H2O = indole-3-acetate + NADH + H+
-
-
-
-
natural substrates
tryptophan 2'-dioxygenase
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3
; "show the reaction diagram")
-
-
-
-
natural substrates
acetyl-CoA C-myristoyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
; "show the reaction diagram")
-
-
-
-
natural substrates
acetyl-CoA C-acyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
-
-
-
-
natural substrates
[acyl-carrier-protein] S-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
-
-
-
-
natural substrates
acetyl-CoA C-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
-
-
-
-
natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
-
-
-
-
natural substrates
3-hydroxybutyryl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
-
-
-
-
natural substrates
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
-
-
-
-
natural substrates
long-chain-3-hydroxyacyl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
-
-
-
-
natural substrates
3-oxoacyl-[acyl-carrier-protein] reductase (NADH)
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
-
-
-
-
natural substrates
3-hydroxyacyl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
-
-
-
-
natural substrates
acetoacetyl-CoA reductase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
-
-
-
-
natural substrates
enoyl-CoA hydratase 2
(3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O
; "show the reaction diagram")
; "show the reaction diagram")
-
-
-
-
natural substrates
crotonobetainyl-CoA hydratase
(3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O
-
-
-
-
natural substrates
short-chain-enoyl-CoA hydratase
(3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O
-
-
-
-
natural substrates
enoyl-CoA hydratase
(3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O
-
-
-
-
natural substrates
3-hydroxybutyryl-CoA dehydratase
(3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O
-
-
-
-
natural substrates
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
(3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O
-
-
-
-
natural substrates
7.2.4.5
glutaconyl-CoA decarboxylase
(2E)-4-carboxybut-2-enoyl-CoA + Na+[side 1] = (2E)-but-2-enoyl-CoA + CO2 + Na+[side 2]
-
-
-
-
natural substrates
glutaryl-CoA dehydrogenase (ETF)
glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein
; "show the reaction diagram")
-
-
-
: subsequently R03028natural substrates, protein
aminomuconate-semialdehyde dehydrogenase
2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + H+
; "show the reaction diagram")
-
-
-
-
natural substrates
aminocarboxymuconate-semialdehyde decarboxylase
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2
; "show the reaction diagram")
-
-
-
-
natural substrates
3-hydroxyanthranilate 3,4-dioxygenase
3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde
; "show the reaction diagram")
-
-
-
-
natural substrates
kynureninase
3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine
; "show the reaction diagram")
-
-
-
-
natural substrates
kynurenine 3-monooxygenase
L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
tryptophanase
L-tryptophan + H2O = indole + pyruvate + NH3
; "show the reaction diagram")
-
-
-
: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)natural substrates, multi-step reaction
anthranilate synthase
chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
; "show the reaction diagram")
-
-
-
-
natural substrates
anthranilate phosphoribosyltransferase
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
; "show the reaction diagram")
-
-
-
-
natural substrates
phosphoribosylanthranilate isomerase
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
; "show the reaction diagram")
-
-
-
-
natural substrates
indole-3-glycerol-phosphate synthase
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
indole-3-glycerol-phosphate lyase
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
; "show the reaction diagram")
-
-
-
: a part of multi-step reaction (ec 4.2.1.20, see R02722, R02340+R00674)natural substrates
tryptophan synthase
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
-
-
-
: a part of multi-step reaction (ec 4.2.1.20, see R02722, R02340+R00674)natural substrates
tryptophanase
L-serine + indole = L-tryptophan + H2O
; "show the reaction diagram")
-
-
-
: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)natural substrates, multi-step reaction
tryptophan synthase (indole-salvaging)
L-serine + indole = L-tryptophan + H2O
-
-
-
: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)natural substrates, multi-step reaction
tryptophan synthase
L-serine + indole = L-tryptophan + H2O
-
-
-
: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)natural substrates, multi-step reaction
tryptophan 2,3-dioxygenase
L-tryptophan + O2 = N-formyl-L-kynurenine
; "show the reaction diagram")
-
-
-
-
natural substrates
peptide-tryptophan 2,3-dioxygenase
L-tryptophan + O2 = N-formyl-L-kynurenine
-
-
-
-
natural substrates
indoleamine 2,3-dioxygenase
L-tryptophan + O2 = N-formyl-L-kynurenine
-
-
-
-
natural substrates
arylformamidase
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
; "show the reaction diagram")
-
-
-
-
natural substrates
kynureninase
L-kynurenine + H2O = anthranilate + L-alanine
; "show the reaction diagram")
-
-
-
-
natural substrates
aspartate transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
; "show the reaction diagram")
-
-
-
-
natural substrates
diiodotyrosine transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
thyroid-hormone transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
tryptophan transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
tryptophan-phenylpyruvate transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
branched-chain-amino-acid transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
tyrosine transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
kynurenine-oxoglutarate transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
histidinol-phosphate transaminase
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
aromatic 2-oxoacid reductase
(R)-(indol-3-yl)lactate + NAD+ = (indol-3-yl)pyruvate + NADH + H+
; "show the reaction diagram")
-
-
-
-
natural substrates
L-tryptophan decarboxylase
L-tryptophan = tryptamine + CO2
; "show the reaction diagram")
-
-
-
-
natural substrates
aromatic-L-amino-acid decarboxylase
L-tryptophan = tryptamine + CO2
-
-
-
-
natural substrates
phenylalanine decarboxylase
L-tryptophan = tryptamine + CO2
-
-
-
-
natural substrates
putrescine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
; "show the reaction diagram")
-
-
-
-
natural substrates
primary-amine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
natural substrates
diamine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
natural substrates
monoamine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
natural substrates
pyridoxal 5'-phosphate synthase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
natural substrates
non-specific polyamine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
natural substrates
aldehyde oxidase
(indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2
; "show the reaction diagram")
-
-
-
-
natural substrates
indole-3-acetaldehyde oxidase
(indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2
-
-
-
-
natural substrates
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
; "show the reaction diagram")
-
-
-
-
natural substrates
alcohol dehydrogenase
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
-
-
-
-
natural substrates
indole-3-acetaldehyde reductase (NADH)
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
-
-
-
-
natural substrates
aldose reductase
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
-
-
-
-
natural substrates
2-aminomuconate deaminase (2-hydroxymuconate-forming)
2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
; "show the reaction diagram")
; "show the reaction diagram")
-
-
-
-
natural substrates
2-aminomuconate deaminase
2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
-
-
-
-
natural substrates
2-oxo-3-hexenedioate decarboxylase
4-Oxalocrotonate = 2-Oxopent-4-enoate + CO2
; "show the reaction diagram")
-
-
-
-
natural substrates
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
(indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
; "show the reaction diagram")
-
-
-
-
natural substrates, generic, protein
indolepyruvate ferredoxin oxidoreductase
(indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
-
-
-
-
natural substrates, generic, protein
glutaryl-CoA dehydrogenase (ETF)
glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein
; "show the reaction diagram")
-
-
-
-
natural substrates, protein
tryptophan-tRNA ligase
ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp
-
-
-
-
natural substrates, nucleotide
kynurenine-oxoglutarate transaminase
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
; "show the reaction diagram")
-
-
-
: the first step of two-step reaction (see R12688, R01956+R03445)natural substrates
cysteine-conjugate transaminase
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
-
-
-
: the first step of two-step reaction (see R12688, R01956+R03445)natural substrates
cyclopeptine synthase
2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine
; "show the reaction diagram")
-
-
-
-
natural substrates
medium-chain acyl-CoA ligase
ATP + anthranilate + CoA = AMP + diphosphate + anthraniloyl-CoA
; "show the reaction diagram")
-
-
-
-
natural substrates
benzoate-CoA ligase
ATP + anthranilate + CoA = AMP + diphosphate + anthraniloyl-CoA
-
-
-
-
natural substrates
anthranilate-CoA ligase
ATP + anthranilate + CoA = AMP + diphosphate + anthraniloyl-CoA
-
-
-
-
natural substrates
anthraniloyl-CoA anthraniloyltransferase
anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = S-anthraniloyl-L-cysteinyl-[PqsD protein] + CoA
n.a.
-
-
-
natural substrates
2-aminomuconate deaminase
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3
-
-
-
-
natural substrates