Print
chondro-6-sulfatase
Pathways
sulfated glycosaminoglycan metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate
; "show the reaction diagram")
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natural substrates
gellan tetrasaccharide unsaturated glucuronosyl hydrolase
beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate
; "show the reaction diagram")
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natural substrates
unsaturated chondroitin disaccharide hydrolase
beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate
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natural substrates
chondroitin-sulfate-ABC endolyase
chondroitin 6-sulfate = unsaturated chondroitin 6-sulfate disaccharide
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polymer
chondroitin-sulfate-ABC exolyase
chondroitin 6-sulfate = unsaturated chondroitin 6-sulfate disaccharide
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polymer
chondroitin-sulfate-ABC endolyase
chondroitin 4-sulfate = 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose
; "show the reaction diagram")
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natural substrates
chondroitin-sulfate-ABC exolyase
chondroitin 4-sulfate = 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose
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natural substrates
chondroitin AC lyase
chondroitin 4-sulfate = 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose
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natural substrates
2-dehydro-3-deoxy-phosphogluconate aldolase
2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate
; "show the reaction diagram")
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natural substrates
2-dehydro-3-deoxyglucarate aldolase
2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate
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natural substrates
2-dehydro-3-deoxy-D-gluconate aldolase
2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate
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natural substrates
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate
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natural substrates
2-dehydro-3-deoxyglucono/galactono-kinase
ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
; "show the reaction diagram")
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natural substrates
2-dehydro-3-deoxygluconokinase
ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
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natural substrates
dehydrogluconokinase
ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
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natural substrates
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
2,5-didehydro-3-deoxy-D-gluconate + NADPH + H+ = 2-dehydro-3-deoxy-D-gluconate + NADP+
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natural substrates
5-dehydro-4-deoxy-D-glucuronate isomerase
5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate
; "show the reaction diagram")
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natural substrates
4-deoxy-L-threo-5-hexosulose-uronate = 5-dehydro-4-deoxy-D-glucuronate
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natural substrates
0.0.0.0
spontaneous reaction
4-deoxy-L-threo-5-hexosulose-uronate = 5-dehydro-4-deoxy-D-glucuronate
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natural substrates
gellan tetrasaccharide unsaturated glucuronosyl hydrolase
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-GalNAc
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generic
unsaturated chondroitin disaccharide hydrolase
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-GalNAc
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generic
chondro-4-sulfatase
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate
; "show the reaction diagram")
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natural substrates
chondroitin B lyase
[dermatan sulfate]n = [dermatan sulfate]n-1 + 4-deoxy-beta-D-gluc-4-enuronosyl-1,3-GalNAc-4-sulfate
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natural substrates, generic, polymer
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
3'-phospho-5'-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
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natural substrates, generic
chondroitin-glucuronate 5-epimerase
Chondroitin D-glucuronate = dermatan L-iduronate
; "show the reaction diagram")
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natural substrates
chondroitin 6-sulfotransferase
3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
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natural substrates, polymer
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
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natural substrates, polymer
chondroitin 6-sulfotransferase
3'-phosphoadenylylsulfate + chondroitin 4-sulfate = adenosine 3',5'-bisphosphate + chondroitin 4,6-bissulfate
; "show the reaction diagram")
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natural substrates
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
3'-phosphoadenylylsulfate + chondroitin 4-sulfate = adenosine 3',5'-bisphosphate + chondroitin 4,6-bissulfate
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natural substrates
chondroitin 6-sulfotransferase
3'-phosphoadenylylsulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
; "show the reaction diagram")
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natural substrates
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
3'-phosphoadenylylsulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
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natural substrates
chondroitin 4-sulfotransferase
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
; "show the reaction diagram")
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natural substrates
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
UDP-alpha-D-glucuronate + [protein]-3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
n.a.
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natural substrates
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n+1-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
n.a.
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natural substrates
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
UDP-N-acetyl-D-galactosamine + D-Glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan <=> UDP + N-Acetyl-beta-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan
; "show the reaction diagram")
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natural substrates
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
n.a.
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natural substrates
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
; "show the reaction diagram")
; "show the reaction diagram")
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natural substrates, protein
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
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natural substrates
galactosylxylosylprotein 3-beta-galactosyltransferase
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
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natural substrates
galactosylxylosylprotein 3-beta-galactosyltransferase
UDP-alpha-D-galactose + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
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natural substrates, protein
xylosylprotein 4-beta-galactosyltransferase
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
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natural substrates
protein xylosyltransferase
UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
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natural substrates, protein