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BRENDA KEGG MetaCyc

serotonin metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
tryptophan 5-monooxygenase
L-Tryptophan + Tetrahydropteridine + Oxygen <=> 5-Hydroxy-L-tryptophan + 4a-Hydroxy-5,6,7,8-tetrahydropteridine
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natural substrates
aromatic-L-amino-acid decarboxylase
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2
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natural substrates
phenylalanine decarboxylase
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2
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natural substrates
arylamine N-acetyltransferase
acetyl-CoA + serotonin = CoA + N-acetylserotonin
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natural substrates
aralkylamine N-acetyltransferase
acetyl-CoA + serotonin = CoA + N-acetylserotonin
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natural substrates
acetylserotonin O-methyltransferase
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin
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natural substrates
aryl sulfotransferase
3'-phosphoadenylylsulfate + 5-hydroxytryptamine = adenosine 3',5'-bisphosphate + 3-(2-aminoethyl)-5-indoxyl sulfate
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natural substrates
primary-amine oxidase
serotonin + H2O + O2 = (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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natural substrates
monoamine oxidase
serotonin + H2O + O2 = (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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natural substrates
aldehyde dehydrogenase (NAD+)
5-hydroxyindol acetaldehyde + NAD+ + H2O = 5-hydroxyindol acetate + NADH
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natural substrates
aldehyde dehydrogenase [NAD(P)+]
5-hydroxyindol acetaldehyde + NAD+ + H2O = 5-hydroxyindol acetate + NADH
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natural substrates
glucuronosyltransferase
UDP-glucuronate + 5-hydroxytryptophol = UDP + 5-hydroxytryptophol beta-D-glucuronide
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natural substrates