Pathways
propionate fermentation (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
methylmalonyl-CoA = propionyl-CoA + CO2
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: Malonyl-CoA decarboxylase (EryM, Saccharopolyspora erythraea)
natural substrates
malonyl-CoA decarboxylase
methylmalonyl-CoA = propionyl-CoA + CO2
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: Malonyl-CoA decarboxylase (EryM, Saccharopolyspora erythraea)
natural substrates
ethylmalonyl-CoA decarboxylase
methylmalonyl-CoA = propionyl-CoA + CO2
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: Malonyl-CoA decarboxylase (EryM, Saccharopolyspora erythraea)
natural substrates
4.1.1.M5
methylmalonyl-CoA = propionyl-CoA + CO2
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: Malonyl-CoA decarboxylase (EryM, Saccharopolyspora erythraea)
natural substrates
propionyl-CoA carboxylase
methylmalonyl-CoA = propionyl-CoA + CO2
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: Malonyl-CoA decarboxylase (EryM, Saccharopolyspora erythraea)
natural substrates
carboxymethylproline synthase
methylmalonyl-CoA = propionyl-CoA + CO2
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: Malonyl-CoA decarboxylase (EryM, Saccharopolyspora erythraea)
natural substrates
methylmalonyl-CoA epimerase
(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
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natural substrates
aconitate hydratase
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O
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: reversible reaction Ref. 1: Biosci. Biotech. Biochem., 59 (11), 2013-2017, 1995
natural substrates
2-methylisocitrate dehydratase
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O
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: reversible reaction Ref. 1: Biosci. Biotech. Biochem., 59 (11), 2013-2017, 1995
natural substrates
citrate (Si)-synthase
propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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natural substrates
citrate synthase (unknown stereospecificity)
propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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natural substrates
2-methylcitrate synthase
propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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natural substrates
isocitrate lyase
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = succinate + pyruvate
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natural substrates
Methylisocitrate lyase
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = succinate + pyruvate
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natural substrates
methylmalonyl-CoA carboxytransferase
(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate
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natural substrates
methylmalonyl-CoA mutase
(R)-methylmalonyl-CoA = succinyl-CoA
: Valine, leucine and isoleucine degradation,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
3-hydroxypropanoate/4-hydroxybutanate cycle,
pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
3-hydroxypropanoate/4-hydroxybutanate cycle,
pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
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natural substrates
ethylmalonyl-CoA mutase
(R)-methylmalonyl-CoA = succinyl-CoA
: Valine, leucine and isoleucine degradation,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
3-hydroxypropanoate/4-hydroxybutanate cycle,
pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
3-hydroxypropanoate/4-hydroxybutanate cycle,
pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
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natural substrates
2-hydroxyisobutanoyl-CoA mutase
(R)-methylmalonyl-CoA = succinyl-CoA
: Valine, leucine and isoleucine degradation,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
3-hydroxypropanoate/4-hydroxybutanate cycle,
pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
3-hydroxypropanoate/4-hydroxybutanate cycle,
pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
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natural substrates
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O
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natural substrates
2-methylcitrate dehydratase
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O
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natural substrates