Pathways

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BRENDA KEGG MetaCyc

phenylalanine metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
(E)-cinnamoyl-CoA + (R)-(phenyl)lactate = (E)-cinnamate + (R)-(phenyl)lactoyl-CoA
: phenylalanine metabolism
: Tropane, piperidine and pyridine alkaloid biosynthesis,
Biosynthesis of secondary metabolites
: L-phenylalanine degradation VI (reductive Stickland reaction)
: BR47452show the reaction diagram
: R07796show the reaction diagram
: 2.8.3.17-RXNshow the reaction diagram
-
-
-
-
natural substrates
chorismate mutase
Chorismate = prephenate
: phenylalanine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II,
L-tyrosine biosynthesis III,
L-tyrosine biosynthesis II,
L-tyrosine biosynthesis I,
bacilysin biosynthesis,
L-phenylalanine biosynthesis I,
salinosporamide A biosynthesis
: BR252show the reaction diagram
: R01715show the reaction diagram
: CHORISMATEMUT-RXNshow the reaction diagram
: 1827
-
-
-
-
natural substrates
phenylalanine racemase (ATP-hydrolysing)
ATP + L-phenylalanine + H2O = AMP + diphosphate + D-phenylalanine
: phenylalanine metabolism
: Phenylalanine metabolism,
D-Amino acid metabolism,
Metabolic pathways
: BR164show the reaction diagram
: R00686show the reaction diagram
: 5.1.1.11-RXNshow the reaction diagram
-
-
-
: multi-step reaction (ligating L-phenylalanine and [enzyme]-thiol, epimerizing and thioester-hydrolysing)
natural substrates, multi-step reaction
alcohol dehydrogenase
phenylethanol + NAD+ = phenylacetaldehyde + NADH
: phenylalanine metabolism
: Phenylalanine metabolism
: phenylethanol biosynthesis,
L-phenylalanine degradation III
: BS186840show the reaction diagram
: R02611show the reaction diagram
: RXN-7700show the reaction diagram
: 2516
-
-
-
-
natural substrates
indole-3-acetaldehyde reductase (NADH)
phenylethanol + NAD+ = phenylacetaldehyde + NADH
: phenylalanine metabolism
: Phenylalanine metabolism
: phenylethanol biosynthesis,
L-phenylalanine degradation III
: BS186840show the reaction diagram
: R02611show the reaction diagram
: RXN-7700show the reaction diagram
: 2516
-
-
-
-
natural substrates
alcohol dehydrogenase [NAD(P)+]
phenylethanol + NAD+ = phenylacetaldehyde + NADH
: phenylalanine metabolism
: Phenylalanine metabolism
: phenylethanol biosynthesis,
L-phenylalanine degradation III
: BS186840show the reaction diagram
: R02611show the reaction diagram
: RXN-7700show the reaction diagram
: 2516
-
-
-
-
natural substrates
aryl-alcohol dehydrogenase
phenylethanol + NAD+ = phenylacetaldehyde + NADH
: phenylalanine metabolism
: Phenylalanine metabolism
: phenylethanol biosynthesis,
L-phenylalanine degradation III
: BS186840show the reaction diagram
: R02611show the reaction diagram
: RXN-7700show the reaction diagram
: 2516
-
-
-
-
natural substrates
(S)-specific secondary alcohol dehydrogenase
phenylethanol + NAD+ = phenylacetaldehyde + NADH
: phenylalanine metabolism
: Phenylalanine metabolism
: phenylethanol biosynthesis,
L-phenylalanine degradation III
: BS186840show the reaction diagram
: R02611show the reaction diagram
: RXN-7700show the reaction diagram
: 2516
-
-
-
-
natural substrates
alanine-oxo-acid transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
glutamine-pyruvate transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
alanine-glyoxylate transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
serine-pyruvate transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
phenylalanine(histidine) transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
glutamine-phenylpyruvate transaminase
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-homophenylalanine biosynthesis,
L-phenylalanine degradation III
: BR47420show the reaction diagram
: R00692show the reaction diagram
: 2.6.1.58-RXNshow the reaction diagram
: 1072
-
-
-
-
natural substrates
aminobutyraldehyde dehydrogenase
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
: phenylalanine metabolism
: Phenylalanine metabolism,
Styrene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: phenylethanol degradation,
styrene degradation,
phenylethylamine degradation II,
L-phenylalanine degradation IV (mammalian, via side chain),
phenylethylamine degradation I,
L-phenylalanine degradation II (anaerobic)
: BR36781show the reaction diagram, BS374293show the reaction diagram
: R02536show the reaction diagram
: PHENDEHYD-RXNshow the reaction diagram
: 2456
-
-
-
: NADP+ (see R02537)
natural substrates
aldehyde dehydrogenase (NAD+)
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
: phenylalanine metabolism
: Phenylalanine metabolism,
Styrene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: phenylethanol degradation,
styrene degradation,
phenylethylamine degradation II,
L-phenylalanine degradation IV (mammalian, via side chain),
phenylethylamine degradation I,
L-phenylalanine degradation II (anaerobic)
: BR36781show the reaction diagram, BS374293show the reaction diagram
: R02536show the reaction diagram
: PHENDEHYD-RXNshow the reaction diagram
: 2456
-
-
-
: NADP+ (see R02537)
natural substrates
phenylacetaldehyde dehydrogenase
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
: phenylalanine metabolism
: Phenylalanine metabolism,
Styrene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: phenylethanol degradation,
styrene degradation,
phenylethylamine degradation II,
L-phenylalanine degradation IV (mammalian, via side chain),
phenylethylamine degradation I,
L-phenylalanine degradation II (anaerobic)
: BR36781show the reaction diagram, BS374293show the reaction diagram
: R02536show the reaction diagram
: PHENDEHYD-RXNshow the reaction diagram
: 2456
-
-
-
: NADP+ (see R02537)
natural substrates
aldehyde dehydrogenase [NAD(P)+]
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
: phenylalanine metabolism
: Phenylalanine metabolism,
Styrene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: phenylethanol degradation,
styrene degradation,
phenylethylamine degradation II,
L-phenylalanine degradation IV (mammalian, via side chain),
phenylethylamine degradation I,
L-phenylalanine degradation II (anaerobic)
: BR36781show the reaction diagram, BS374293show the reaction diagram
: R02536show the reaction diagram
: PHENDEHYD-RXNshow the reaction diagram
: 2456
-
-
-
: NADP+ (see R02537)
natural substrates
betaine-aldehyde dehydrogenase
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
: phenylalanine metabolism
: Phenylalanine metabolism,
Styrene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: phenylethanol degradation,
styrene degradation,
phenylethylamine degradation II,
L-phenylalanine degradation IV (mammalian, via side chain),
phenylethylamine degradation I,
L-phenylalanine degradation II (anaerobic)
: BR36781show the reaction diagram, BS374293show the reaction diagram
: R02536show the reaction diagram
: PHENDEHYD-RXNshow the reaction diagram
: 2456
-
-
-
: NADP+ (see R02537)
natural substrates
aldehyde ferredoxin oxidoreductase
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
: phenylalanine metabolism
: Phenylalanine metabolism,
Styrene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: phenylethanol degradation,
styrene degradation,
phenylethylamine degradation II,
L-phenylalanine degradation IV (mammalian, via side chain),
phenylethylamine degradation I,
L-phenylalanine degradation II (anaerobic)
: BR36781show the reaction diagram, BS374293show the reaction diagram
: R02536show the reaction diagram
: PHENDEHYD-RXNshow the reaction diagram
: 2456
-
-
-
: NADP+ (see R02537)
natural substrates
phenylpyruvate = phenylacetaldehyde + CO2
: phenylalanine metabolism
: Phenylalanine metabolism,
Metabolic pathways
: L-phenylalanine degradation III,
L-phenylalanine degradation II (anaerobic)
: BR303show the reaction diagram
: R01377show the reaction diagram
: PHENYLPYRUVATE-DECARBOXYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
pyruvate decarboxylase
phenylpyruvate = phenylacetaldehyde + CO2
: phenylalanine metabolism
: Phenylalanine metabolism,
Metabolic pathways
: L-phenylalanine degradation III,
L-phenylalanine degradation II (anaerobic)
: BR303show the reaction diagram
: R01377show the reaction diagram
: PHENYLPYRUVATE-DECARBOXYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
phenylpyruvate decarboxylase
phenylpyruvate = phenylacetaldehyde + CO2
: phenylalanine metabolism
: Phenylalanine metabolism,
Metabolic pathways
: L-phenylalanine degradation III,
L-phenylalanine degradation II (anaerobic)
: BR303show the reaction diagram
: R01377show the reaction diagram
: PHENYLPYRUVATE-DECARBOXYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
benzoylformate decarboxylase
phenylpyruvate = phenylacetaldehyde + CO2
: phenylalanine metabolism
: Phenylalanine metabolism,
Metabolic pathways
: L-phenylalanine degradation III,
L-phenylalanine degradation II (anaerobic)
: BR303show the reaction diagram
: R01377show the reaction diagram
: PHENYLPYRUVATE-DECARBOXYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
branched-chain-2-oxoacid decarboxylase
phenylpyruvate = phenylacetaldehyde + CO2
: phenylalanine metabolism
: Phenylalanine metabolism,
Metabolic pathways
: L-phenylalanine degradation III,
L-phenylalanine degradation II (anaerobic)
: BR303show the reaction diagram
: R01377show the reaction diagram
: PHENYLPYRUVATE-DECARBOXYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
indolepyruvate decarboxylase
phenylpyruvate = phenylacetaldehyde + CO2
: phenylalanine metabolism
: Phenylalanine metabolism,
Metabolic pathways
: L-phenylalanine degradation III,
L-phenylalanine degradation II (anaerobic)
: BR303show the reaction diagram
: R01377show the reaction diagram
: PHENYLPYRUVATE-DECARBOXYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
6,7-dihydropteridine reductase
a 5,6,7,8-tetrahydropteridine + NADP+ = a 6,7-dihydropteridine + NADPH + H+
: phenylalanine metabolism
: tetrahydropteridine recycling
: BR43856show the reaction diagram
: R07355show the reaction diagram
: 1.5.1.34-RXNshow the reaction diagram
-
-
-
: general reaction (see R01794) NAD+ (see R07354 and R01793)
natural substrates
4a-hydroxytetrahydrobiopterin dehydratase
4a-hydroxy-tetrahydrobiopterin = 7,8-dihydrobiopterin + H2O
: phenylalanine metabolism
: Folate biosynthesis,
Metabolic pathways
: BR468show the reaction diagram, BS2138show the reaction diagram
: R04734show the reaction diagram
: RXN-7908show the reaction diagram
-
-
-
-
natural substrates
phenylalanine 4-monooxygenase
L-Phenylalanine + Tetrahydropteridine + Oxygen <=> L-Tyrosine + 4a-Hydroxy-5,6,7,8-tetrahydropteridine
: phenylalanine metabolism
: BR40406show the reaction diagram
: R12540show the reaction diagram
-
-
-
-
natural substrates
prephenate dehydratase
prephenate = phenylpyruvate + H2O + CO2
: phenylalanine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis III (cytosolic, plants),
L-phenylalanine biosynthesis I
: BR3398show the reaction diagram
: R01373show the reaction diagram
: PREPHENATEDEHYDRAT-RXNshow the reaction diagram
: 1575
-
-
-
-
natural substrates
arogenate dehydratase
prephenate = phenylpyruvate + H2O + CO2
: phenylalanine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis III (cytosolic, plants),
L-phenylalanine biosynthesis I
: BR3398show the reaction diagram
: R01373show the reaction diagram
: PREPHENATEDEHYDRAT-RXNshow the reaction diagram
: 1575
-
-
-
-
natural substrates
aspartate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
diiodotyrosine transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
tryptophan transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
2-aminoadipate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
branched-chain-amino-acid transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
tyrosine transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
aromatic-amino-acid transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
aromatic-amino-acid-glyoxylate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
glutamine-phenylpyruvate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
kynurenine-oxoglutarate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
aspartate-phenylpyruvate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
glutamate-prephenate aminotransferase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
histidinol-phosphate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
2-aminobutyrate-2-oxoglutarate transaminase
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
: phenylalanine metabolism
: Phenylalanine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-phenylalanine degradation VI (reductive Stickland reaction),
L-phenylalanine degradation II (anaerobic),
L-phenylalanine degradation III,
L-phenylalanine biosynthesis I,
L-phenylalanine degradation IV (mammalian, via side chain)
: BS353519show the reaction diagram
: R00694show the reaction diagram
: RXN-10814show the reaction diagram
: 1074
-
-
-
: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|.
natural substrates
aspartate transaminase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
: phenylalanine metabolism,
tyrosine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II,
L-tyrosine biosynthesis III,
L-tyrosine biosynthesis II
: BR48630show the reaction diagram
: R07276show the reaction diagram
: PREPHENATE-TRANSAMINE-RXNshow the reaction diagram
: 9205
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
: phenylalanine metabolism,
tyrosine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II,
L-tyrosine biosynthesis III,
L-tyrosine biosynthesis II
: BR48630show the reaction diagram
: R07276show the reaction diagram
: PREPHENATE-TRANSAMINE-RXNshow the reaction diagram
: 9205
-
-
-
-
natural substrates
aspartate-prephenate aminotransferase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
: phenylalanine metabolism,
tyrosine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II,
L-tyrosine biosynthesis III,
L-tyrosine biosynthesis II
: BR48630show the reaction diagram
: R07276show the reaction diagram
: PREPHENATE-TRANSAMINE-RXNshow the reaction diagram
: 9205
-
-
-
-
natural substrates
glutamate-prephenate aminotransferase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
: phenylalanine metabolism,
tyrosine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II,
L-tyrosine biosynthesis III,
L-tyrosine biosynthesis II
: BR48630show the reaction diagram
: R07276show the reaction diagram
: PREPHENATE-TRANSAMINE-RXNshow the reaction diagram
: 9205
-
-
-
-
natural substrates
prephenate dehydratase
L-arogenate = L-phenylalanine + H2O + CO2
: phenylalanine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II
: BR48340show the reaction diagram
: R00691show the reaction diagram
: CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXNshow the reaction diagram
: 1071
-
-
-
-
natural substrates
arogenate dehydratase
L-arogenate = L-phenylalanine + H2O + CO2
: phenylalanine metabolism
: Phenylalanine, tyrosine and tryptophan biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-phenylalanine biosynthesis II
: BR48340show the reaction diagram
: R00691show the reaction diagram
: CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXNshow the reaction diagram
: 1071
-
-
-
-
natural substrates
phenylalanine-tRNA ligase
ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe
: phenylalanine metabolism
: Aminoacyl-tRNA biosynthesis
: BR51show the reaction diagram
: R03660show the reaction diagram
: 409
-
-
-
-
natural substrates
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
phenylpyruvate + CoA + oxidized ferredoxin = phenylacetyl-CoA + CO2 + reduced ferredoxin
: phenylalanine metabolism
: BS359419show the reaction diagram
: RXN-23387show the reaction diagram
-
-
-
-
natural substrates, generic, protein
indolepyruvate ferredoxin oxidoreductase
phenylpyruvate + CoA + oxidized ferredoxin = phenylacetyl-CoA + CO2 + reduced ferredoxin
: phenylalanine metabolism
: BS359419show the reaction diagram
: RXN-23387show the reaction diagram
-
-
-
-
natural substrates, generic, protein
phenylalanine aminomutase (L-beta-phenylalanine forming)
L-phenylalanine = L-beta-phenylalanine
: phenylalanine metabolism
: taxol biosynthesis
: BR50482show the reaction diagram, BR52647show the reaction diagram
: R10286show the reaction diagram, R10287show the reaction diagram
: RXN-13484show the reaction diagram, RXN-13649show the reaction diagram
-
-
-
-
natural substrates
phenylalanine aminomutase (D-beta-phenylalanine forming)
L-phenylalanine = L-beta-phenylalanine
: phenylalanine metabolism
: taxol biosynthesis
: BR50482show the reaction diagram, BR52647show the reaction diagram
: R10286show the reaction diagram, R10287show the reaction diagram
: RXN-13484show the reaction diagram, RXN-13649show the reaction diagram
-
-
-
-
natural substrates
phenyllactyl-CoA dehydratase
(R)-3-(phenyl)lactoyl-CoA = (E)-cinnamoyl-CoA + H2O
: phenylalanine metabolism
: L-phenylalanine degradation VI (reductive Stickland reaction)
: BR51461show the reaction diagram
: R12487show the reaction diagram
: RXN-19883show the reaction diagram
-
-
-
-
natural substrates
3-(aryl)acrylate reductase
3-phenylpropanoate + electron-transfer flavoprotein = trans-cinnamate + reduced electron-transfer flavoprotein
: phenylalanine metabolism
: BR52971show the reaction diagram
: R12535show the reaction diagram
-
-
-
-
natural substrates, protein