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Pathways

phenylacetate degradation (aerobic) (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

4.2.1.17

enoyl-CoA hydratase

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

: phenylacetate degradation (aerobic),
adipate degradation

: Phenylalanine metabolism,
Caprolactam degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: adipate degradation,
adipate biosynthesis,
phenylacetate degradation I (aerobic),
benzoyl-CoA degradation I (aerobic)

: BS417838

: R06942

: RXN-2425

natural substrates

1.14.13.149

phenylacetyl-CoA 1,2-epoxidase

phenylacetyl-CoA + NADPH + H+ + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: phenylacetate degradation I (aerobic)

: BR49984

: R09838

: RXN0-2042

natural substrates

5.3.3.18

2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: phenylacetate degradation I (aerobic)

: BR50000

: R09837

: RXN0-6510

natural substrates

2.3.1.16

acetyl-CoA C-acyltransferase

succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: adipate degradation,
adipate biosynthesis,
benzoyl-CoA degradation I (aerobic),
phenylacetate degradation I (aerobic),
3-oxoadipate degradation

: BR48623

: R00829

: RXN-3641

: 1170

natural substrates

2.3.1.174

3-oxoadipyl-CoA thiolase

succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: adipate degradation,
adipate biosynthesis,
benzoyl-CoA degradation I (aerobic),
phenylacetate degradation I (aerobic),
3-oxoadipate degradation

: BR48623

: R00829

: RXN-3641

: 1170

natural substrates

1.1.1.157

3-hydroxybutyryl-CoA dehydrogenase

(3S)-3-hydroxyadipyl-CoA + NAD+ = 3-oxoadipyl-CoA + NADH + H+

: adipate degradation,
phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Caprolactam degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: adipate degradation,
adipate biosynthesis,
benzoyl-CoA degradation I (aerobic),
phenylacetate degradation I (aerobic)

: BS417822

: R06941

: RXN0-2044

natural substrates

1.1.1.35

3-hydroxyacyl-CoA dehydrogenase

(3S)-3-hydroxyadipyl-CoA + NAD+ = 3-oxoadipyl-CoA + NADH + H+

: adipate degradation,
phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Caprolactam degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: adipate degradation,
adipate biosynthesis,
benzoyl-CoA degradation I (aerobic),
phenylacetate degradation I (aerobic)

: BS417822

: R06941

: RXN0-2044

natural substrates

6.2.1.2

medium-chain acyl-CoA ligase

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: penicillin G and penicillin V biosynthesis,
phenylacetate degradation II (anaerobic),
phenylacetate degradation I (aerobic),
L-phenylalanine degradation IV (mammalian, via side chain)

: BR48383

: R02539

: RXN-10819

: 2458

natural substrates

6.2.1.27

4-hydroxybenzoate-CoA ligase

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: penicillin G and penicillin V biosynthesis,
phenylacetate degradation II (anaerobic),
phenylacetate degradation I (aerobic),
L-phenylalanine degradation IV (mammalian, via side chain)

: BR48383

: R02539

: RXN-10819

: 2458

natural substrates

6.2.1.30

phenylacetate-CoA ligase

ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: penicillin G and penicillin V biosynthesis,
phenylacetate degradation II (anaerobic),
phenylacetate degradation I (aerobic),
L-phenylalanine degradation IV (mammalian, via side chain)

: BR48383

: R02539

: RXN-10819

: 2458

natural substrates

3.3.2.12

oxepin-CoA hydrolase

2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: phenylacetate degradation I (aerobic)

: BR49842

, BS417449

: R09836

: RXNMETA-12671

natural substrates

1.2.1.91

3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase

3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP+ + H2O = 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+

: phenylacetate degradation (aerobic)

: Phenylalanine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments

: phenylacetate degradation I (aerobic)

: BR49826

: R09820

: RXNMETA-12672

natural substrates