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N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
Pathways
peptidoglycan biosynthesis (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-triglycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + 2 glycyl-tRNA = N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-pentaglycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + 2 tRNA
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nucleotide
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + 2 glycyl-tRNA = N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-triglycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + 2 tRNA
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nucleotide
lipid II:glycine glycyltransferase
N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine-diphospho-ditrans,octacis-undecaprenyl-N-acetyl-D-glucosamine + glycyl-tRNAGly = N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphospho-ditrans,octacis-undecaprenyl-N-acetyl-D-glucosamine + tRNAGly
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natural substrates, nucleotide
lipid II isoglutaminyl synthase (glutamine-hydrolysing)
ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + L-glutamine + H2O = ADP + phosphate + beta-D-GlcNAc-(1->4)-MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenol + L-glutamate
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natural substrates
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
UDP-N-acetyl-alpha-D-glucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
; "show the reaction diagram")
; "show the reaction diagram")
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natural substrates
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
; "show the reaction diagram")
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natural substrates
D-stereospecific aminopeptidase
D-Ala-D-Ala + H2O = 2 D-Ala
; "show the reaction diagram")
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natural substrates
non-stereospecific dipeptidase
D-Ala-D-Ala + H2O = 2 D-Ala
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natural substrates
membrane dipeptidase
D-Ala-D-Ala + H2O = 2 D-Ala
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natural substrates
D-Ala-D-Ala dipeptidase
D-Ala-D-Ala + H2O = 2 D-Ala
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natural substrates
serine-type D-Ala-D-Ala carboxypeptidase
D-Ala-D-Ala + H2O = 2 D-Ala
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natural substrates
UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
; "show the reaction diagram")
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natural substrates
UDP-N-acetylmuramate dehydrogenase
UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+
; "show the reaction diagram")
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: NAD+ (see R03191)natural substrates
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
; "show the reaction diagram")
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natural substrates
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
; "show the reaction diagram")
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natural substrates
UDP-N-acetylmuramate-L-alanine ligase
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
; "show the reaction diagram")
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natural substrates
murein peptide ligase
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
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natural substrates
amino-acid racemase
L-glutamate = D-glutamate
; "show the reaction diagram")
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natural substrates
glutamate racemase
L-glutamate = D-glutamate
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natural substrates
arginine racemase
L-glutamate = D-glutamate
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natural substrates
D-alanine-(R)-lactate ligase
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
; "show the reaction diagram")
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natural substrates
D-alanine-D-serine ligase
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
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natural substrates
D-Alanine-D-alanine ligase
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
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natural substrates
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-diaminopimelic acid + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-diaminopimeloyl-D-alanyl-D-alanine
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phospho-N-acetylmuramoyl-pentapeptide-transferase
UDP-N-acetylmuramoyl-pentapeptide + undecaprenyl phosphate = UMP + N-acetylmuramoyl-pentapeptide-diphosphoundecaprenol
; "show the reaction diagram")
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natural substrates
undecaprenyl-diphosphate phosphatase
ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate
; "show the reaction diagram")
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natural substrates
phosphatidylglycerophosphatase
ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate
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natural substrates
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
; "show the reaction diagram")
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natural substrates
D-Alanine-D-alanine ligase
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
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natural substrates
phospho-N-acetylmuramoyl-pentapeptide-transferase
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
; "show the reaction diagram")
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natural substrates
ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
; "show the reaction diagram")
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: 8-step reaction see R05555+R08748+R08749+R08750+R08751+R08752+R08753+R07269natural substrates
2.5.1.M1
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
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: 8-step reaction see R05555+R08748+R08749+R08750+R08751+R08752+R08753+R07269natural substrates