EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
7.1.1.8
quinol-cytochrome-c reductase
ubiquinol + cytochrome c2 = ubiquinone + reduced cytochrome c2
n.a.
-
-
-
-
7.1.1.9
cytochrome-c oxidase
reduced cytochrome c + O2 + H+ = oxidized cytochrome c + H2O
generic compounds
-
-
-
generic, protein
electron-transferring-flavoprotein dehydrogenase
reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol
-
-
-
-
natural substrates, protein
ubiquinol oxidase (non-electrogenic)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]

:
aerobic respiration III (alternative oxidase pathway),
pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
-
-
-

: two-step reaction (see R11885+R11886)
natural substrates
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]

:
aerobic respiration III (alternative oxidase pathway),
pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
-
-
-

: two-step reaction (see R11885+R11886)
natural substrates
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]

:
aerobic respiration III (alternative oxidase pathway),
pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
-
-
-

: two-step reaction (see R11885+R11886)
natural substrates
7.1.1.3
ubiquinol oxidase (H+-transporting)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]

:
aerobic respiration III (alternative oxidase pathway),
pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
-
-
-

: two-step reaction (see R11885+R11886)
natural substrates
7.1.1.5
menaquinol oxidase (H+-transporting)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]

:
aerobic respiration III (alternative oxidase pathway),
pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
-
-
-

: two-step reaction (see R11885+R11886)
natural substrates
7.1.1.7
quinol oxidase (electrogenic, proton-motive force generating)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]

:
aerobic respiration III (alternative oxidase pathway),
pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
-
-
-

: two-step reaction (see R11885+R11886)
natural substrates
7.1.1.2
NADH:ubiquinone reductase (H+-translocating)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
7.2.1.1
NADH:ubiquinone reductase (Na+-transporting)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
NADPH dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
NADH dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
NAD(P)H dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
NADH:quinone reductase (non-electrogenic)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
dihydrolipoyl dehydrogenase
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]

:
Fe(II) oxidation,
aerobic respiration I (cytochrome c),
aerobic respiration III (alternative oxidase pathway),
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD(P)/NADPH interconversion,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
mitochondrial NADPH production (yeast)
-
-
-

: electron transport complex I
natural substrates, multi-step reaction
ferredoxin-NADP+ reductase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
-
-
-
-
natural substrates
ferredoxin-NAD+ reductase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
-
-
-
-
natural substrates
adrenodoxin-NADP+ reductase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
-
-
-
-
natural substrates
7.1.1.11
ferredoxin-NAD+ oxidoreductase (H+-transporting)
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
nucleoside-triphosphate phosphatase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
non-chaperonin molecular chaperone ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
peroxisome-assembly ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing)
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
chromosome segregation protein SegA
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
presynaptic-filament-stabilizing ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
archaeal flagellar ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
microtubule-severing ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
7.1.2.1
P-type H+-exporting transporter
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
7.1.2.2
H+-transporting two-sector ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
7.2.2.1
Na+-transporting two-sector ATPase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
7.6.2.1
P-type phospholipid transporter
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
7.6.2.2
ABC-type xenobiotic transporter
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
tRNAMet cytidine acetyltransferase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
mitogen-activated protein kinase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
N-acylneuraminate-9-phosphatase
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates
ATP + H2O = ADP + phosphate
-
-
-
-
natural substrates