Print
morphine 6-dehydrogenase
Pathways
morphine biosynthesis (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
morphine + NADP+ = morphinone + NADPH + H+
; "show the reaction diagram")
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: NAD+ (see R03591)natural substrates
codeinone reductase (NADPH)
morphine + NADP+ = morphinone + NADPH + H+
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: NAD+ (see R03591)natural substrates
thebaine 6-O-demethylase
oripavine + 2-oxoglutarate + O2 = morphinone + formaldehyde + succinate + CO2
; "show the reaction diagram")
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natural substrates
codeine 3-O-demethylase
thebaine + 2-oxoglutarate + O2 = oripavine + formaldehyde + succinate + CO2
; "show the reaction diagram")
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natural substrates
codeine 3-O-demethylase
codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2
; "show the reaction diagram")
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natural substrates
morphine 6-dehydrogenase
codeine + NADP+ = codeinone + NADPH + H+
; "show the reaction diagram")
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natural substrates
codeinone reductase (NADPH)
codeine + NADP+ = codeinone + NADPH + H+
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natural substrates
neopinone = codeinone
; "show the reaction diagram")
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natural substrates
0.0.0.0
spontaneous reaction
neopinone = codeinone
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natural substrates
thebaine 6-O-demethylase
thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + CO2
; "show the reaction diagram")
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natural substrates
1,2-dehydroreticuline synthase
(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = 1,2-dehydroreticuline + [oxidized NADPH-hemoprotein reductase] + 2 H2O
; "show the reaction diagram")
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natural substrates, generic, protein
1,2-dehydroreticulinium reductase (NADPH)
(R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+
; "show the reaction diagram")
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natural substrates
salutaridine synthase
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = salutaridine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
; "show the reaction diagram")
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natural substrates, generic, protein
salutaridine reductase (NADPH)
salutaridinol + NADP+ = salutaridine + NADPH + H+
; "show the reaction diagram")
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natural substrates
Salutaridinol 7-O-acetyltransferase
acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol
; "show the reaction diagram")
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natural substrates
thebaine synthase
salutaridinol 7-O-acetate = thebaine + acetate
; "show the reaction diagram")
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: The reaction occurs spontaneously when the pH is between 8-9.: The reaction occurs spontaneously at pH 8-9 [8537369]. However, it requires EC-4.2.99.24, at neutral pH [29807982].natural substrates