mevalonate-3-phosphate 5-kinase
Pathways
mevalonate metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + (R)-3-phosphomevalonate = ADP + (R)-3,5-bisphosphomevalonate
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natural substrates
mevalonate 3-kinase
ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate
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natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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natural substrates
hydroxymethylglutaryl-CoA reductase
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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natural substrates
hydroxymethylglutaryl-CoA reductase [NAD(P)H]
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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natural substrates
acetyl-CoA C-myristoyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
acetyl-CoA C-acyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
[acyl-carrier-protein] S-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
acetyl-CoA C-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: pyruvate fermentation to hexanol (engineered),
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
3-hydroxypropanoate/4-hydroxybutanate cycle,
L-glutamate degradation V (via hydroxyglutarate),
acetyl-CoA fermentation to butanoate,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
2-deoxy-D-ribose degradation II,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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natural substrates
hydroxymethylglutaryl-CoA reductase
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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natural substrates
hydroxymethylglutaryl-CoA reductase [NAD(P)H]
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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natural substrates
mevalonate kinase
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
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natural substrates
hydroxymethylglutaryl-CoA synthase
acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
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: possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)
natural substrates
isopentenyl-diphosphate DELTA-isomerase
Isopentenyl diphosphate = dimethylallyl diphosphate
: mevalonate pathway IV (archaea),
mono-trans, poly-cis decaprenyl phosphate biosynthesis,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
all-trans-farnesol biosynthesis,
methylerythritol phosphate pathway I,
methylerythritol phosphate pathway II,
isoprene biosynthesis II (engineered),
bisabolene biosynthesis (engineered),
mevalonate pathway II (haloarchaea)
mono-trans, poly-cis decaprenyl phosphate biosynthesis,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
all-trans-farnesol biosynthesis,
methylerythritol phosphate pathway I,
methylerythritol phosphate pathway II,
isoprene biosynthesis II (engineered),
bisabolene biosynthesis (engineered),
mevalonate pathway II (haloarchaea)
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natural substrates
isopentenyl phosphate kinase
ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate
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natural substrates
phosphomevalonate decarboxylase
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2
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natural substrates
phosphomevalonate kinase
ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate
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natural substrates
diphosphomevalonate decarboxylase
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2
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: possibly intermediate ((R)-5-diphospho-3-phosphomevalonate)
natural substrates
bisphosphomevalonate decarboxylase
(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate
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: This hypothetical reaction is catalyzed by an as yet unidentified mevalonate-3,5-bisphosphate decarboxylase |CITS: [24914732][24755225]|.
natural substrates
adenylate dimethylallyltransferase (ADP/ATP-dependent)
dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate
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natural substrates
adenylate dimethylallyltransferase
dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate
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natural substrates
isoprene synthase
dimethylallyl diphosphate = isoprene + diphosphate
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natural substrates