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BRENDA KEGG MetaCyc

methylaspartate cycle (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
isocitrate dehydrogenase (NAD+)
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
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: two-step reaction (see R01899+R00268)
natural substrates
isocitrate dehydrogenase (NADP+)
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
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-
: two-step reaction (see R01899+R00268)
natural substrates
homoisocitrate dehydrogenase
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
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-
-
: two-step reaction (see R01899+R00268)
natural substrates
citrate (Si)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: The mammalian citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol [4211224].
natural substrates
homocitrate synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: The mammalian citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol [4211224].
natural substrates
citrate synthase (unknown stereospecificity)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: The mammalian citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol [4211224].
natural substrates
citrate (Re)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: The mammalian citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol [4211224].
natural substrates
succinyl-CoA:mesaconate CoA transferase
mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
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natural substrates