Print
methionine-tRNA ligase
Pathways
methionine metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
; "show the reaction diagram")
-
-
-
-
natural substrates
adenosylhomocysteinase
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
; "show the reaction diagram")
-
-
-
: multi-step reactionnatural substrates, multi-step reaction
S-adenosylhomocysteine deaminase
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
-
-
-
: multi-step reactionnatural substrates, multi-step reaction
adenosylhomocysteinase
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
-
-
-
: multi-step reactionnatural substrates, multi-step reaction
cystathionine gamma-synthase
O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate
-
-
-
-
natural substrates
methionine gamma-lyase
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
; "show the reaction diagram")
-
-
-
: multi-step reaction (see R08635+R08637)natural substrates, multi-step reaction
DNA (cytosine-5-)-methyltransferase
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
; "show the reaction diagram")
-
-
-
: see R04858natural substrates, nucleotide
methionine adenosyltransferase
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
; "show the reaction diagram")
-
-
-
: possibly intermediate (triphosphate, see [CPD:C00536])natural substrates
homocysteine S-methyltransferase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
; "show the reaction diagram")
-
-
-
-
natural substrates
methionine synthase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
-
-
-
-
natural substrates
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
-
-
-
-
natural substrates
selenocysteine Se-methyltransferase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
-
-
-
-
natural substrates
betaine-homocysteine S-methyltransferase
betaine + L-homocysteine = dimethylglycine + L-methionine
; "show the reaction diagram")
-
-
-
-
natural substrates
methionine synthase
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine
; "show the reaction diagram")
-
-
-
-
natural substrates
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine
-
-
-
-
natural substrates
methionine synthase
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
; "show the reaction diagram")
-
-
-
-
natural substrates
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
-
-
-
-
natural substrates
cystathionine beta-synthase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
; "show the reaction diagram")
-
-
-
-
natural substrates
cystathionine gamma-lyase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
-
-
-
-
natural substrates
cysteine-S-conjugate beta-lyase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
-
-
-
-
natural substrates
L-cysteine desulfidase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
-
-
-
-
natural substrates
dimethylpropiothetin dethiomethylase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
-
-
-
-
natural substrates
cystathionine gamma-synthase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
-
-
-
-
natural substrates
mimosinase
L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
-
-
-
-
natural substrates
cystathionine gamma-synthase
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
; "show the reaction diagram")
; "show the reaction diagram")
-
-
-
-
natural substrates
homoserine O-succinyltransferase
succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine
; "show the reaction diagram")
-
-
-
-
natural substrates
asparagine-oxo-acid transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
glutamine-pyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
tryptophan-phenylpyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
branched-chain-amino-acid transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
serine-pyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
phenylalanine(histidine) transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
aromatic-amino-acid-glyoxylate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
glutamine-phenylpyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
methionine transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
-
-
-
-
natural substrates
L-amino-acid oxidase
L-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
; "show the reaction diagram")
-
-
-
-
natural substrates
phenylalanine 2-monooxygenase
L-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
-
natural substrates
acireductone dioxygenase (Ni2+-requiring)
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-(methylsulfanyl)-2-oxobutanoate + formate
; "show the reaction diagram")
-
-
-
-
natural substrates
acireductone dioxygenase [iron(II)-requiring]
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-(methylsulfanyl)-2-oxobutanoate + formate
-
-
-
-
natural substrates
acireductone synthase
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
; "show the reaction diagram")
-
-
-
: the second step of two-step reaction (see R07395, R07393+R07394)natural substrates
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
-
-
-
: the second step of two-step reaction (see R07395, R07393+R07394)natural substrates
acireductone synthase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
; "show the reaction diagram")
-
-
-
: the first step of two-step reaction (see R07395, R07393+R07394) in some species.natural substrates
ribulose-bisphosphate carboxylase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
-
-
-
: the first step of two-step reaction (see R07395, R07393+R07394) in some species.natural substrates
phosphopyruvate hydratase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
-
-
-
: the first step of two-step reaction (see R07395, R07393+R07394) in some species.natural substrates
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
-
-
-
: the first step of two-step reaction (see R07395, R07393+R07394) in some species.natural substrates
methylthioribulose 1-phosphate dehydratase
5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-(methylsulfanyl)-2,3-dioxopentyl phosphate + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
S-methyl-5-thioribose-1-phosphate isomerase
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
; "show the reaction diagram")
-
-
-
-
natural substrates
S-methyl-5-thioribose kinase
ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate
; "show the reaction diagram")
-
-
-
-
natural substrates
methylthioadenosine nucleosidase
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine
; "show the reaction diagram")
-
-
-
-
natural substrates
adenosylhomocysteine nucleosidase
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine
-
-
-
-
natural substrates
arginine decarboxylase
S-adenosyl-L-methionine = S-adenosyl 3-(methylsulfanyl)propylamine + CO2
; "show the reaction diagram")
-
-
-
-
natural substrates
adenosylmethionine decarboxylase
S-adenosyl-L-methionine = S-adenosyl 3-(methylsulfanyl)propylamine + CO2
-
-
-
-
natural substrates
adenosylhomocysteine nucleosidase
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
; "show the reaction diagram")
-
-
-
-
natural substrates
purine-nucleoside phosphorylase
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
-
-
-
natural substrates
S-methyl-5'-thioadenosine phosphorylase
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
-
-
-
natural substrates
methionine transaminase
L-methionine + a 2-oxo carboxylate = 4-(methylsulfanyl)-2-oxobutanoate + an L-amino acid
; "show the reaction diagram")
-
-
-
-
natural substrates
methylthioadenosine nucleosidase
S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
; "show the reaction diagram")
-
-
-
-
natural substrates
aminodeoxyfutalosine nucleosidase
S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
natural substrates
adenosylhomocysteine nucleosidase
S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
natural substrates
S-ribosylhomocysteine lyase
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione
; "show the reaction diagram")
-
-
-
-
natural substrates
peptide-methionine (S)-S-oxide reductase
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
; "show the reaction diagram")
-
-
-
-
natural substrates
peptide-methionine (R)-S-oxide reductase
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
-
-
-
-
natural substrates
L-methionine (R)-S-oxide reductase
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
-
-
-
-
natural substrates
thioredoxin-independent methionine sulfoxide reductases B
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
-
-
-
-
natural substrates
nicotianamine synthase
3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine
; "show the reaction diagram")
-
-
-
: multi-step reactionnatural substrates, multi-step reaction
S-adenosyl-L-methionine hydroxide adenosyltransferase
S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+
-
-
-
-
natural substrates
(R)-S-adenosyl-L-methionine hydrolase (adenosine-forming)
S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+
-
-
-
-
natural substrates