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Pathways

metabolism of amino sugars and derivatives (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

1.1.1.336

UDP-N-acetyl-D-mannosamine dehydrogenase

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: UDP-N-acetyl-alpha-D-mannosaminouronate biosynthesis

: BR50229

: R03317

: UDPMANNACADEHYDROG-RXN

: 3129

natural substrates

2.7.1.2

glucokinase

ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: N-acetylneuraminate and N-acetylmannosamine degradation I,
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)

: BS357665

: R02705

: NANK-RXN

: 2597

natural substrates

2.7.1.59

N-acetylglucosamine kinase

ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: N-acetylneuraminate and N-acetylmannosamine degradation I,
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)

: BS357665

: R02705

: NANK-RXN

: 2597

natural substrates

2.7.1.60

N-acylmannosamine kinase

ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: N-acetylneuraminate and N-acetylmannosamine degradation I,
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)

: BS357665

: R02705

: NANK-RXN

: 2597

natural substrates

4.1.3.3

N-acetylneuraminate lyase

aceneuramate = N-acetyl-D-mannosamine + pyruvate

: metabolism of amino sugars and derivatives

: N-acetylneuraminate and N-acetylmannosamine degradation II,
N-acetylneuraminate and N-acetylmannosamine degradation I

: BR3374

: R12768

: RXN0-7390

natural substrates

2.5.1.56

N-acetylneuraminate synthase

phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: BR47462

: R01804

: 1890

natural substrates

5.1.3.14

UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)

UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: poly(glycerol phosphate) wall teichoic acid biosynthesis,
poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus),
poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis),
Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis,
UDP-N-acetyl-alpha-D-mannosaminouronate biosynthesis,
Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis,
Salmonella enterica serotype O:54 O antigen biosynthesis,
poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis

: BR189

: R00420

: UDPGLCNACEPIM-RXN

: 875

: possibly intermediate (2-acetamido-D-glucal)

natural substrates

2.7.7.43

N-acylneuraminate cytidylyltransferase

CTP + N-acetyl-neuraminic acid = CMP-Neu5Ac + diphosphate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: CMP-N-acetylneuraminate biosynthesis II (bacteria),
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)

: BS388407

: R01117

: RXN-9990

: 1376

natural substrates

2.7.7.92

3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase

CTP + N-acetyl-neuraminic acid = CMP-Neu5Ac + diphosphate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of nucleotide sugars

: CMP-N-acetylneuraminate biosynthesis II (bacteria),
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)

: BS388407

: R01117

: RXN-9990

: 1376

natural substrates

5.1.3.9

N-acylglucosamine-6-phosphate 2-epimerase

N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: N-acetylneuraminate and N-acetylmannosamine degradation I

: BS368626

: R02087

: NANE-RXN

natural substrates

3.5.99.6

glucosamine-6-phosphate deaminase

D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism

: N-acetylglucosamine degradation I,
UDP-N-acetyl-D-galactosamine biosynthesis II,
chitin derivatives degradation,
chitin degradation I (archaea)

: BS363214

: R00765

: GLUCOSAMINE-6-P-DEAMIN-RXN

: 34

natural substrates

3.5.1.25

N-acetylglucosamine-6-phosphate deacetylase

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

: metabolism of amino sugars and derivatives

: Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: N-acetylglucosamine degradation I,
peptidoglycan recycling I,
chitin derivatives degradation

: BR26100

: R02059

: NAG6PDEACET-RXN

: 2076

natural substrates