Pathways

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BRENDA KEGG MetaCyc

lysine metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
D-amino-acid oxidase
D-Lys + H2O + O2 = 6-amino-2-oxohexanoic acid + NH3 + H2O2
: lysine metabolism
: L-lysine degradation V
: BS388458show the reaction diagram
: RXN-8163show the reaction diagram
: 7752
-
-
-
: This deaminating oxidation reaction is incompletely characterized [17259313].
natural substrates
3-keto-5-aminohexanoate cleavage enzyme
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine fermentation to acetate and butanoate
: BR51399show the reaction diagram
: R10564show the reaction diagram
: R125-RXNshow the reaction diagram
-
-
-
-
natural substrates
L-erythro-3,5-diaminohexanoate dehydrogenase
L-erythro-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxohexanoate + NH3 + NADH + H+
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine fermentation to acetate and butanoate
: BR36859show the reaction diagram
: R03349show the reaction diagram
: 1.4.1.11-RXNshow the reaction diagram
-
-
-
-
natural substrates
lysine 5,6-aminomutase
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine fermentation to acetate and butanoate
: BR27show the reaction diagram
: R03275show the reaction diagram
: BETA-LYSINE-56-AMINOMUTASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
4-hydroxy-tetrahydrodipicolinate reductase
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+
: lysine metabolism
: Monobactam biosynthesis,
Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I,
L-lysine biosynthesis VI,
L-lysine biosynthesis III,
L-lysine biosynthesis II
: BR36807show the reaction diagram
: R04199show the reaction diagram
: RXN-14014show the reaction diagram
-
-
-
: NAD+ (see R04198)
: Studies of the enzyme from the bacterium TAX-562 have shown that the enzyme accepts CPD-14443 and not 2-3-DIHYDRODIPICOLINATE as originally thought [20503968].
natural substrates
4-hydroxy-tetrahydrodipicolinate synthase
pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
: lysine metabolism
: Monobactam biosynthesis,
Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: dipicolinate biosynthesis,
L-lysine biosynthesis I,
L-lysine biosynthesis VI,
L-lysine biosynthesis III,
L-lysine biosynthesis II
: BR3399show the reaction diagram
: R10147show the reaction diagram
: DIHYDRODIPICSYN-RXNshow the reaction diagram
: 16203
-
-
-
-
natural substrates
lysine 2,3-aminomutase
L-lysine = (3S)-3,6-diaminohexanoate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine fermentation to acetate and butanoate
: BR26show the reaction diagram
: R00461show the reaction diagram
: LYSINE-23-AMINOMUTASE-RXNshow the reaction diagram
-
-
-
: radical intermediate
natural substrates
4-aminobutyrate-2-oxoglutarate transaminase
L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate
: lysine metabolism
: L-lysine degradation VI
: BR47436show the reaction diagram, BS354059show the reaction diagram
: R00457show the reaction diagram
: L-LYSINE-AMINOTRANSFERASE-RXNshow the reaction diagram
: 894
-
-
-
-
natural substrates
L-lysine 6-transaminase
L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate
: lysine metabolism
: L-lysine degradation VI
: BR47436show the reaction diagram, BS354059show the reaction diagram
: R00457show the reaction diagram
: L-LYSINE-AMINOTRANSFERASE-RXNshow the reaction diagram
: 894
-
-
-
-
natural substrates
5-aminopentanamidase
5-aminopentanamide + H2O = 5-aminopentanoate + NH3
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: L-lysine degradation IV
: BR19244show the reaction diagram
: R02273show the reaction diagram
: 5-AMINOPENTANAMIDASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
alanine racemase
L-lysine = D-lysine
: lysine metabolism
: Lysine degradation,
D-Amino acid metabolism,
Metabolic pathways
: L-lysine degradation V
: BR173show the reaction diagram
: R00460show the reaction diagram
: LYSINE-RACEMASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
amino-acid racemase
L-lysine = D-lysine
: lysine metabolism
: Lysine degradation,
D-Amino acid metabolism,
Metabolic pathways
: L-lysine degradation V
: BR173show the reaction diagram
: R00460show the reaction diagram
: LYSINE-RACEMASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
lysine racemase
L-lysine = D-lysine
: lysine metabolism
: Lysine degradation,
D-Amino acid metabolism,
Metabolic pathways
: L-lysine degradation V
: BR173show the reaction diagram
: R00460show the reaction diagram
: LYSINE-RACEMASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
arginine racemase
L-lysine = D-lysine
: lysine metabolism
: Lysine degradation,
D-Amino acid metabolism,
Metabolic pathways
: L-lysine degradation V
: BR173show the reaction diagram
: R00460show the reaction diagram
: LYSINE-RACEMASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
L-aminoadipate-semialdehyde dehydrogenase
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NAD+ + 2 H2O <=> L-2-Aminoadipate + NADH + H+
: lysine metabolism
: L-lysine degradation II (L-pipecolate pathway),
L-lysine degradation V,
L-lysine degradation VI
: BS189205show the reaction diagram, BS451452show the reaction diagram
: R11231show the reaction diagram
: RXN-10855_WOPThis reaction also exists with phosphate.show the reaction diagram, RXN-8162show the reaction diagram
-
-
-
: second step of two-step reaction (see R03102, R02317+R11231)
natural substrates
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NAD+ + 2 H2O <=> L-2-Aminoadipate + NADH + H+
: lysine metabolism
: L-lysine degradation II (L-pipecolate pathway),
L-lysine degradation V,
L-lysine degradation VI
: BS189205show the reaction diagram, BS451452show the reaction diagram
: R11231show the reaction diagram
: RXN-10855_WOPThis reaction also exists with phosphate.show the reaction diagram, RXN-8162show the reaction diagram
-
-
-
: second step of two-step reaction (see R03102, R02317+R11231)
natural substrates
L-pipecolate oxidase
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation V,
L-lysine degradation II (L-pipecolate pathway)
: BR36911show the reaction diagram, BS259362show the reaction diagram
: R02204show the reaction diagram
: L-PIPECOLATE-OXIDASE-RXNshow the reaction diagram
: 2176
-
-
-
-
natural substrates
0.0.0.0
spontaneous reaction
2-oxo-6-amino-hexanoate + D-lysine = DELTA1-piperidine 2-carboxylate
: lysine metabolism
: BR52892show the reaction diagram
incomplete
-
O3C6H16N2
-
natural substrates
2-oxo-6-amino-hexanoate + hydrogen peroxide = 5-aminopentanoate + H2O + CO2
: lysine metabolism
: L-lysine degradation VII
: BR52891show the reaction diagram
: RXN-8243show the reaction diagram
-
-
-
-
natural substrates
0.0.0.0
spontaneous reaction
2-oxo-6-amino-hexanoate + hydrogen peroxide = 5-aminopentanoate + H2O + CO2
: lysine metabolism
: L-lysine degradation VII
: BR52891show the reaction diagram
: RXN-8243show the reaction diagram
-
-
-
-
natural substrates
L-lysine oxidase
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways
: L-lysine degradation II (L-pipecolate pathway),
L-lysine degradation VII
: BR36876show the reaction diagram
: R00447show the reaction diagram
: L-LYSINE-OXIDASE-RXNshow the reaction diagram
: 887
-
-
-
-
natural substrates
L-amino-acid oxidase
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways
: L-lysine degradation II (L-pipecolate pathway),
L-lysine degradation VII
: BR36876show the reaction diagram
: R00447show the reaction diagram
: L-LYSINE-OXIDASE-RXNshow the reaction diagram
: 887
-
-
-
-
natural substrates
L-arginine oxidase
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways
: L-lysine degradation II (L-pipecolate pathway),
L-lysine degradation VII
: BR36876show the reaction diagram
: R00447show the reaction diagram
: L-LYSINE-OXIDASE-RXNshow the reaction diagram
: 887
-
-
-
-
natural substrates
lysine 2-monooxygenase
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways
: L-lysine degradation II (L-pipecolate pathway),
L-lysine degradation VII
: BR36876show the reaction diagram
: R00447show the reaction diagram
: L-LYSINE-OXIDASE-RXNshow the reaction diagram
: 887
-
-
-
-
natural substrates
saccharopine dehydrogenase (NAD+, L-glutamate-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-lysine degradation XI
: BR37178show the reaction diagram, BS261177show the reaction diagram
: R02313show the reaction diagram
: 1.5.1.9-RXNshow the reaction diagram
: 2273
-
-
-
-
natural substrates
aspartate transaminase
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine degradation V,
L-lysine degradation II (L-pipecolate pathway),
L-lysine biosynthesis IV,
L-lysine biosynthesis V,
L-lysine degradation XI
: BR47689show the reaction diagram, BS356308show the reaction diagram
: R01939show the reaction diagram
: 2-AMINOADIPATE-AMINOTRANSFERASE-RXNshow the reaction diagram
: 1992
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine degradation V,
L-lysine degradation II (L-pipecolate pathway),
L-lysine biosynthesis IV,
L-lysine biosynthesis V,
L-lysine degradation XI
: BR47689show the reaction diagram, BS356308show the reaction diagram
: R01939show the reaction diagram
: 2-AMINOADIPATE-AMINOTRANSFERASE-RXNshow the reaction diagram
: 1992
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine degradation V,
L-lysine degradation II (L-pipecolate pathway),
L-lysine biosynthesis IV,
L-lysine biosynthesis V,
L-lysine degradation XI
: BR47689show the reaction diagram, BS356308show the reaction diagram
: R01939show the reaction diagram
: 2-AMINOADIPATE-AMINOTRANSFERASE-RXNshow the reaction diagram
: 1992
-
-
-
-
natural substrates
kynurenine-oxoglutarate transaminase
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine degradation V,
L-lysine degradation II (L-pipecolate pathway),
L-lysine biosynthesis IV,
L-lysine biosynthesis V,
L-lysine degradation XI
: BR47689show the reaction diagram, BS356308show the reaction diagram
: R01939show the reaction diagram
: 2-AMINOADIPATE-AMINOTRANSFERASE-RXNshow the reaction diagram
: 1992
-
-
-
-
natural substrates
saccharopine dehydrogenase (NADP+, L-lysine-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-lysine degradation XI
: BR36904show the reaction diagram
: R00716show the reaction diagram
: 1.5.1.8-RXNshow the reaction diagram
: 1088
-
-
-
-
natural substrates
ornithine decarboxylase
L-lysine = cadaverine + CO2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
: L-lysine degradation X,
L-lysine degradation I,
cadaverine biosynthesis,
bisucaberin biosynthesis,
desferrioxamine E biosynthesis,
desferrioxamine B biosynthesis,
lupanine biosynthesis,
aminopropylcadaverine biosynthesis
: BR6435show the reaction diagram
: R00462show the reaction diagram
: LYSDECARBOX-RXNshow the reaction diagram
: 899
-
-
-
-
natural substrates
lysine decarboxylase
L-lysine = cadaverine + CO2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
: L-lysine degradation X,
L-lysine degradation I,
cadaverine biosynthesis,
bisucaberin biosynthesis,
desferrioxamine E biosynthesis,
desferrioxamine B biosynthesis,
lupanine biosynthesis,
aminopropylcadaverine biosynthesis
: BR6435show the reaction diagram
: R00462show the reaction diagram
: LYSDECARBOX-RXNshow the reaction diagram
: 899
-
-
-
-
natural substrates
arginine decarboxylase
L-lysine = cadaverine + CO2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
: L-lysine degradation X,
L-lysine degradation I,
cadaverine biosynthesis,
bisucaberin biosynthesis,
desferrioxamine E biosynthesis,
desferrioxamine B biosynthesis,
lupanine biosynthesis,
aminopropylcadaverine biosynthesis
: BR6435show the reaction diagram
: R00462show the reaction diagram
: LYSDECARBOX-RXNshow the reaction diagram
: 899
-
-
-
-
natural substrates
adenosylmethionine decarboxylase
L-lysine = cadaverine + CO2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
: L-lysine degradation X,
L-lysine degradation I,
cadaverine biosynthesis,
bisucaberin biosynthesis,
desferrioxamine E biosynthesis,
desferrioxamine B biosynthesis,
lupanine biosynthesis,
aminopropylcadaverine biosynthesis
: BR6435show the reaction diagram
: R00462show the reaction diagram
: LYSDECARBOX-RXNshow the reaction diagram
: 899
-
-
-
-
natural substrates
diaminobutyrate decarboxylase
L-lysine = cadaverine + CO2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
: L-lysine degradation X,
L-lysine degradation I,
cadaverine biosynthesis,
bisucaberin biosynthesis,
desferrioxamine E biosynthesis,
desferrioxamine B biosynthesis,
lupanine biosynthesis,
aminopropylcadaverine biosynthesis
: BR6435show the reaction diagram
: R00462show the reaction diagram
: LYSDECARBOX-RXNshow the reaction diagram
: 899
-
-
-
-
natural substrates
lysine/ornithine carboxy-lyase
L-lysine = cadaverine + CO2
: lysine metabolism
: Lysine degradation,
Tropane, piperidine and pyridine alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
: L-lysine degradation X,
L-lysine degradation I,
cadaverine biosynthesis,
bisucaberin biosynthesis,
desferrioxamine E biosynthesis,
desferrioxamine B biosynthesis,
lupanine biosynthesis,
aminopropylcadaverine biosynthesis
: BR6435show the reaction diagram
: R00462show the reaction diagram
: LYSDECARBOX-RXNshow the reaction diagram
: 899
-
-
-
-
natural substrates
lysine 2-monooxygenase
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: L-lysine degradation IV
: BR40522show the reaction diagram
: R00449show the reaction diagram
: LYSINE-2-MONOOXYGENASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+
: lysine metabolism
: L-lysine degradation III,
L-lysine degradation X,
L-lysine degradation I,
L-lysine degradation IV
: BR29392show the reaction diagram
: R10982show the reaction diagram
: RXN-8182show the reaction diagram
-
-
-
-
natural substrates
glutarate-semialdehyde dehydrogenase
5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+
: lysine metabolism
: L-lysine degradation III,
L-lysine degradation X,
L-lysine degradation I,
L-lysine degradation IV
: BR29392show the reaction diagram
: R10982show the reaction diagram
: RXN-8182show the reaction diagram
-
-
-
-
natural substrates
beta-alanine—2-oxoglutarate transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: L-lysine degradation III,
L-lysine degradation X,
L-lysine degradation I,
L-lysine degradation IV
: BR47695show the reaction diagram
: R02274show the reaction diagram
: VAGL-RXNshow the reaction diagram
-
-
-
-
natural substrates
4-aminobutyrate-2-oxoglutarate transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: L-lysine degradation III,
L-lysine degradation X,
L-lysine degradation I,
L-lysine degradation IV
: BR47695show the reaction diagram
: R02274show the reaction diagram
: VAGL-RXNshow the reaction diagram
-
-
-
-
natural substrates
alanine transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: L-lysine degradation III,
L-lysine degradation X,
L-lysine degradation I,
L-lysine degradation IV
: BR47695show the reaction diagram
: R02274show the reaction diagram
: VAGL-RXNshow the reaction diagram
-
-
-
-
natural substrates
5-aminovalerate transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: L-lysine degradation III,
L-lysine degradation X,
L-lysine degradation I,
L-lysine degradation IV
: BR47695show the reaction diagram
: R02274show the reaction diagram
: VAGL-RXNshow the reaction diagram
-
-
-
-
natural substrates
5-acetamidopentanoate + H2O = acetate + 5-aminopentanoate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation III
: BS189973show the reaction diagram
: R02276show the reaction diagram
: AMVAL-RXNshow the reaction diagram
-
-
-
-
natural substrates
4-acetamidobutyrate deacetylase
5-acetamidopentanoate + H2O = acetate + 5-aminopentanoate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation III
: BS189973show the reaction diagram
: R02276show the reaction diagram
: AMVAL-RXNshow the reaction diagram
-
-
-
-
natural substrates
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation III
: BS354063show the reaction diagram
: R04029show the reaction diagram
: ACETCAPR-RXNshow the reaction diagram
-
-
-
-
natural substrates
L-lysine 6-transaminase
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation III
: BS354063show the reaction diagram
: R04029show the reaction diagram
: ACETCAPR-RXNshow the reaction diagram
-
-
-
-
natural substrates
N6-acetyl-beta-lysine transaminase
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation III
: BS354063show the reaction diagram
: R04029show the reaction diagram
: ACETCAPR-RXNshow the reaction diagram
-
-
-
-
natural substrates
2-aminohexanoate transaminase
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
: lysine metabolism
: Lysine degradation,
Metabolic pathways
: L-lysine degradation III
: BS354063show the reaction diagram
: R04029show the reaction diagram
: ACETCAPR-RXNshow the reaction diagram
-
-
-
-
natural substrates
L-aminoadipate-semialdehyde dehydrogenase
(S)-2-amino-6-oxohexanoate + NADP+ + H2O = L-2-aminoadipate + NADPH + H+
: lysine metabolism
: Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-lysine degradation XI
: BR29399show the reaction diagram, BS460135show the reaction diagram, BS460773show the reaction diagram
: R03103show the reaction diagram
: 1.2.1.31-RXNshow the reaction diagram
: 2941
-
-
-
: NAD+ (see R03102) two-step reaction (see R02317+R11232)
natural substrates
saccharopine dehydrogenase (NADP+, L-glutamate-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis IV
: BR40355show the reaction diagram, BS287686show the reaction diagram
: R02315show the reaction diagram
: RXN3O-127show the reaction diagram
-
-
-
-
natural substrates
saccharopine dehydrogenase (NAD+, L-lysine-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis IV
: BR37179show the reaction diagram
: R00715show the reaction diagram
: 1.5.1.7-RXNshow the reaction diagram
: 1087
-
-
-
-
natural substrates
saccharopine dehydrogenase (NADP+, L-lysine-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
: lysine metabolism
: Lysine biosynthesis,
Lysine degradation,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis IV
: BR37179show the reaction diagram
: R00715show the reaction diagram
: 1.5.1.7-RXNshow the reaction diagram
: 1087
-
-
-
-
natural substrates
SPONTANEOUS
L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis III
: BR52889show the reaction diagram
: R04336show the reaction diagram
: RXN-4821show the reaction diagram
-
-
-
: non-enzymatic
natural substrates
0.0.0.0
spontaneous reaction
L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis III
: BR52889show the reaction diagram
: R04336show the reaction diagram
: RXN-4821show the reaction diagram
-
-
-
: non-enzymatic
natural substrates
L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis III
: BR52889show the reaction diagram
: R04336show the reaction diagram
: RXN-4821show the reaction diagram
-
-
-
: non-enzymatic
natural substrates
diaminopimelate dehydrogenase
meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis III
: BR36864show the reaction diagram
: R02755show the reaction diagram
: DIAMINOPIMELATE-DEHYDROGENASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
succinyldiaminopimelate transaminase
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I
: BR47417show the reaction diagram
: R04475show the reaction diagram
: SUCCINYLDIAMINOPIMTRANS-RXNshow the reaction diagram
-
-
-
-
natural substrates
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I
: BR43980show the reaction diagram, BS456718show the reaction diagram
: R04365show the reaction diagram
: TETHYDPICSUCC-RXNshow the reaction diagram
-
-
-
-
natural substrates
4-hydroxy-tetrahydrodipicolinate reductase
2,3-dihydrodipicolinate + NADH = 2,3,4,5-tetrahydrodipicolinate + NAD+
: lysine metabolism
: BS258380_WOPThis reaction also exists with phosphate.show the reaction diagram
: 3914
-
-
-
-
natural substrates
4-hydroxy-tetrahydrodipicolinate synthase
L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O
: lysine metabolism
: BS18740show the reaction diagram, BS415661show the reaction diagram
: 12754, 2256
-
-
-
-
-
succinyl-diaminopimelate desuccinylase
N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I
: BR26098show the reaction diagram, BS414993show the reaction diagram
: R02734show the reaction diagram
: SUCCDIAMINOPIMDESUCC-RXNshow the reaction diagram
: 2621
-
-
-
-
natural substrates
LL-diaminopimelate aminotransferase
LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis VI
: BR48748show the reaction diagram, BS424856show the reaction diagram
: R07613show the reaction diagram
: RXN-7737show the reaction diagram
: 12290
-
-
-
-
natural substrates
amino-acid racemase
LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate
: lysine metabolism
: Lysine biosynthesis,
D-Amino acid metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I,
L-lysine biosynthesis VI,
L-lysine biosynthesis II
: BR175show the reaction diagram
: R02735show the reaction diagram
: DIAMINOPIMEPIM-RXNshow the reaction diagram
: 2622
-
-
-
-
natural substrates
diaminopimelate epimerase
LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate
: lysine metabolism
: Lysine biosynthesis,
D-Amino acid metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I,
L-lysine biosynthesis VI,
L-lysine biosynthesis II
: BR175show the reaction diagram
: R02735show the reaction diagram
: DIAMINOPIMEPIM-RXNshow the reaction diagram
: 2622
-
-
-
-
natural substrates
diaminopimelate decarboxylase
meso-2,6-Diaminoheptanedioate = L-lysine + CO2
: lysine metabolism
: Lysine biosynthesis,
D-Amino acid metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of amino acids
: L-lysine biosynthesis I,
L-lysine biosynthesis VI,
L-lysine biosynthesis III,
L-lysine biosynthesis II
: BR281show the reaction diagram, BS390203show the reaction diagram, BS416933show the reaction diagram
: R00451show the reaction diagram
: DIAMINOPIMDECARB-RXNshow the reaction diagram
: 890
-
-
-
-
natural substrates
N-acetyldiaminopimelate deacetylase
N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis II
: BR19248show the reaction diagram, BS116335show the reaction diagram
: R02733show the reaction diagram
: N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
2,3,4,5-Tetrahydrodipicolinate + Acetyl-CoA + H2O <=> N-Acetyl-L-2-amino-6-oxopimelate + CoA
: lysine metabolism
: Monobactam biosynthesis,
Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis II
: BR44091show the reaction diagram
: R04364show the reaction diagram
: 2.3.1.89-RXNshow the reaction diagram
-
-
-
-
natural substrates
tetrahydrodipicolinate N-acetyltransferase
2,3,4,5-Tetrahydrodipicolinate + Acetyl-CoA + H2O <=> N-Acetyl-L-2-amino-6-oxopimelate + CoA
: lysine metabolism
: Monobactam biosynthesis,
Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-lysine biosynthesis II
: BR44091show the reaction diagram
: R04364show the reaction diagram
: 2.3.1.89-RXNshow the reaction diagram
-
-
-
-
natural substrates
isocitrate-homoisocitrate dehydrogenase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR48021show the reaction diagram
: R01934show the reaction diagram
: RXN-7970show the reaction diagram
: 1988
-
-
-
: two-step reaction (see R04862+R01936), reversible
natural substrates
isocitrate dehydrogenase (NADP+)
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR48021show the reaction diagram
: R01934show the reaction diagram
: RXN-7970show the reaction diagram
: 1988
-
-
-
: two-step reaction (see R04862+R01936), reversible
natural substrates
homoisocitrate dehydrogenase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR48021show the reaction diagram
: R01934show the reaction diagram
: RXN-7970show the reaction diagram
: 1988
-
-
-
: two-step reaction (see R04862+R01936), reversible
natural substrates
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR49014show the reaction diagram, BS1972show the reaction diagram
: R03444show the reaction diagram
: RXN3O-1983show the reaction diagram
: 3238
-
-
-
: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
methanogen homoaconitase
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR49014show the reaction diagram, BS1972show the reaction diagram
: R03444show the reaction diagram
: RXN3O-1983show the reaction diagram
: 3238
-
-
-
: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
homoaconitate hydratase
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR49014show the reaction diagram, BS1972show the reaction diagram
: R03444show the reaction diagram
: RXN3O-1983show the reaction diagram
: 3238
-
-
-
: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR49014show the reaction diagram, BS1972show the reaction diagram
: R03444show the reaction diagram
: RXN3O-1983show the reaction diagram
: 3238
-
-
-
: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
homocitrate synthase
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
: lysine metabolism
: Lysine biosynthesis,
Pyruvate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: FeMo cofactor biosynthesis,
L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR44122show the reaction diagram, BS321812show the reaction diagram
: R00271show the reaction diagram
: HOMOCITRATE-SYNTHASE-RXNshow the reaction diagram
: 532
-
-
-
-
natural substrates
methanogen homoaconitase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR416show the reaction diagram
: R04371show the reaction diagram
: HOMOACONITATE-HYDRATASE-RXNshow the reaction diagram
: 4067
-
-
-
: second step of two-step reaction (see R09720, R03444+R04371)
: Requires a CPD-7 for activity. In contrast to EC 4.2.1.36, ENZRXN-7008, this enzyme can catalyze both the dehydration of HOMO-CIT to form HOMO-CIS-ACONITATE and the subsequent hydration reaction that forms HOMO-I-CIT. In addition to HOMO-CIS-ACONITATE, the enzyme can also catalyze the hydration of the physiological substrates CPD-152 and CPD-301 as well as the non-physiological substrate CPD-10749. CIS-ACONITATE, THREO-DS-ISO-CITRATE and CPD-10745 cannot act as substrates, and CPD-150 and CPD-149 act as inhibitors of the enzyme [18765671].
natural substrates
homoaconitate hydratase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
: lysine metabolism
: Lysine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-lysine biosynthesis IV,
coenzyme B biosynthesis,
L-lysine biosynthesis V
: BR416show the reaction diagram
: R04371show the reaction diagram
: HOMOACONITATE-HYDRATASE-RXNshow the reaction diagram
: 4067
-
-
-
: second step of two-step reaction (see R09720, R03444+R04371)
: Requires a CPD-7 for activity. In contrast to EC 4.2.1.36, ENZRXN-7008, this enzyme can catalyze both the dehydration of HOMO-CIT to form HOMO-CIS-ACONITATE and the subsequent hydration reaction that forms HOMO-I-CIT. In addition to HOMO-CIS-ACONITATE, the enzyme can also catalyze the hydration of the physiological substrates CPD-152 and CPD-301 as well as the non-physiological substrate CPD-10749. CIS-ACONITATE, THREO-DS-ISO-CITRATE and CPD-10745 cannot act as substrates, and CPD-150 and CPD-149 act as inhibitors of the enzyme [18765671].
natural substrates
lysine-tRNA ligase
ATP + L-lysine + tRNALys = AMP + diphosphate + L-lysyl-tRNALys
: lysine metabolism
: Aminoacyl-tRNA biosynthesis
: BR57show the reaction diagram
: R03658show the reaction diagram
: 414
-
-
-
-
natural substrates
[amino group carrier protein]-L-2-aminoadipate ligase
ATP + an [amino group carrier protein]-C-terminal-L-glutamate + L-2-aminoadipate = ADP + phosphate + an [amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutyl)-L-glutamine
: lysine metabolism
: BR50906show the reaction diagram
-
-
-
-
natural substrates
[amino group carrier protein]-L-2-aminoadipate 6-kinase
ATP + an [amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine = ADP + phosphate + an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine
: lysine metabolism
: BR53029show the reaction diagram
generic compounds
-
-
-
natural substrates, generic
[amino group carrier protein]-6-phospho-L-2-aminoadipate reductase
an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP+ = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H+
: lysine metabolism
: BR52965show the reaction diagram
generic compounds
-
-
-
natural substrates
[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase
an [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
: lysine metabolism
: BR52999show the reaction diagram
-
-
-
-
natural substrates
[amino group carrier protein]-lysine hydrolase
[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-lysine
: lysine metabolism
: BR52699show the reaction diagram
n.a.
-
-
-
natural substrates