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acetate-CoA ligase (ADP-forming)
Pathways
isoleucine metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + 2-methylbutyrate + CoA = ADP + phosphate + 2-methylbutyryl-CoA
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carboxylic acid-CoA ligase (NDP-forming)
ATP + 2-methylbutyrate + CoA = ADP + phosphate + 2-methylbutyryl-CoA
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3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
2-keto-3-methylvalerate + CoA + oxidized ferredoxin = 2-methylbutanoyl-CoA + CO2 + reduced ferredoxin
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3-methyloxaloacetate = 2-oxobutanoate + CO2
; "show the reaction diagram")
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natural substrates
oxaloacetate decarboxylase
3-methyloxaloacetate = 2-oxobutanoate + CO2
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natural substrates
2-isopropylmalate synthase
acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate
; "show the reaction diagram")
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natural substrates
(R)-citramalate synthase
acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate
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natural substrates
maleate hydratase
(R)-2-Methylmalate = 2-methylmaleate + H2O
; "show the reaction diagram")
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natural substrates
(R)-2-methylmalate dehydratase
(R)-2-Methylmalate = 2-methylmaleate + H2O
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natural substrates
branched-chain-amino-acid transaminase
L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate
: Valine, leucine and isoleucine degradation,Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-isoleucine degradation III (oxidative Stickland reaction),anteiso-branched-chain fatty acid biosynthesis,
L-isoleucine biosynthesis V,
L-isoleucine biosynthesis I (from threonine),
L-isoleucine degradation I,
L-isoleucine biosynthesis II,
L-isoleucine biosynthesis IV,
L-isoleucine biosynthesis III,
L-isoleucine degradation II
; "show the reaction diagram")
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: Also acts on L-leucine and L-valine.natural substrates
2-aminohexanoate transaminase
L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate
: Valine, leucine and isoleucine degradation,Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-isoleucine degradation III (oxidative Stickland reaction),anteiso-branched-chain fatty acid biosynthesis,
L-isoleucine biosynthesis V,
L-isoleucine biosynthesis I (from threonine),
L-isoleucine degradation I,
L-isoleucine biosynthesis II,
L-isoleucine biosynthesis IV,
L-isoleucine biosynthesis III,
L-isoleucine degradation II
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: Also acts on L-leucine and L-valine.natural substrates
(R)-amine:2-oxo acid transaminase
L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate
: Valine, leucine and isoleucine degradation,Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-isoleucine degradation III (oxidative Stickland reaction),anteiso-branched-chain fatty acid biosynthesis,
L-isoleucine biosynthesis V,
L-isoleucine biosynthesis I (from threonine),
L-isoleucine degradation I,
L-isoleucine biosynthesis II,
L-isoleucine biosynthesis IV,
L-isoleucine biosynthesis III,
L-isoleucine degradation II
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: Also acts on L-leucine and L-valine.natural substrates
ketol-acid reductoisomerase (NADP+)
2-aceto-2-hydroxybutyrate + NADPH = 2,3-dihydroxy-3-methylvalerate + NADP+
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natural substrates
dihydroxy-acid dehydratase
2,3-dihydroxy-3-methylpentanoate = 3-methyl-2-oxopentanoate + H2O
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pyruvate synthase
2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin
; "show the reaction diagram")
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natural substrates, generic, protein
2-oxoacid oxidoreductase (ferredoxin)
2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin
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natural substrates, generic, protein
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin
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natural substrates, generic, protein
acetate-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
; "show the reaction diagram")
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: two-step reaction (see R01354+R00926)natural substrates
propionate-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
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: two-step reaction (see R01354+R00926)natural substrates
medium-chain acyl-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
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: two-step reaction (see R01354+R00926)natural substrates
phenylacetate-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
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: two-step reaction (see R01354+R00926)natural substrates
3-hydroxypropionyl-CoA synthase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
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: two-step reaction (see R01354+R00926)natural substrates
3-(methylthio)propionyl-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
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: two-step reaction (see R01354+R00926)natural substrates
isoleucine-tRNA ligase
ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle
; "show the reaction diagram")
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natural substrates
valine-tRNA ligase
ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle
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natural substrates