Pathways

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BRENDA KEGG MetaCyc

histidine metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
histidine-tRNA ligase
ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis
: histidine metabolism
: Aminoacyl-tRNA biosynthesis
: BR52show the reaction diagram
: R03655show the reaction diagram
: 410
-
-
-
-
natural substrates
SPONTANEOUS
H2O + 4-oxoglutaramate = 2-oxoglutarate + NH3 + H+
: histidine metabolism
: Histidine metabolism
: L-histidine degradation VI
: BR52884show the reaction diagram
: R00270show the reaction diagram
: RXN-7594show the reaction diagram
-
-
-
: non-enzymatic hydrolysis
natural substrates
0.0.0.0
spontaneous reaction
H2O + 4-oxoglutaramate = 2-oxoglutarate + NH3 + H+
: histidine metabolism
: Histidine metabolism
: L-histidine degradation VI
: BR52884show the reaction diagram
: R00270show the reaction diagram
: RXN-7594show the reaction diagram
-
-
-
: non-enzymatic hydrolysis
natural substrates
SPONTANEOUS
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = 4-oxoglutaramate + formate + NH3
: histidine metabolism
: Histidine metabolism
: BR52885show the reaction diagram
: R04283show the reaction diagram
incomplete
O2H2
-
: multi-step reaction non-enzymatic incomplete reaction
natural substrates, multi-step reaction
0.0.0.0
spontaneous reaction
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = 4-oxoglutaramate + formate + NH3
: histidine metabolism
: Histidine metabolism
: BR52885show the reaction diagram
: R04283show the reaction diagram
incomplete
O2H2
-
: multi-step reaction non-enzymatic incomplete reaction
natural substrates, multi-step reaction
H2O + formyl-isoglutamine = isoglutamine + formate
: histidine metabolism
: L-histidine degradation VI
: BR52886show the reaction diagram
: RXN-7592show the reaction diagram
-
-
-
-
natural substrates
0.0.0.0
spontaneous reaction
H2O + formyl-isoglutamine = isoglutamine + formate
: histidine metabolism
: L-histidine degradation VI
: BR52886show the reaction diagram
: RXN-7592show the reaction diagram
-
-
-
-
natural substrates
SPONTANEOUS
H+ + H2O + 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = formyl-isoglutamine
: histidine metabolism
: Histidine metabolism
: L-histidine degradation VI
: BR52887show the reaction diagram
: R04282show the reaction diagram
: RXN-7587show the reaction diagram
-
-
-
: non-enzymatic
natural substrates
0.0.0.0
spontaneous reaction
H+ + H2O + 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = formyl-isoglutamine
: histidine metabolism
: Histidine metabolism
: L-histidine degradation VI
: BR52887show the reaction diagram
: R04282show the reaction diagram
: RXN-7587show the reaction diagram
-
-
-
: non-enzymatic
natural substrates
histidine transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
: histidine metabolism
: L-histidine degradation V
: BS353949show the reaction diagram
: RXN-7571show the reaction diagram
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
: histidine metabolism
: L-histidine degradation V
: BS353949show the reaction diagram
: RXN-7571show the reaction diagram
-
-
-
-
natural substrates
alanine-glyoxylate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
: histidine metabolism
: L-histidine degradation V
: BS353949show the reaction diagram
: RXN-7571show the reaction diagram
-
-
-
-
natural substrates
serine-pyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
: histidine metabolism
: L-histidine degradation V
: BS353949show the reaction diagram
: RXN-7571show the reaction diagram
-
-
-
-
natural substrates
phenylalanine(histidine) transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
: histidine metabolism
: L-histidine degradation V
: BS353949show the reaction diagram
: RXN-7571show the reaction diagram
-
-
-
-
natural substrates
glutamine-phenylpyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
: histidine metabolism
: L-histidine degradation V
: BS353949show the reaction diagram
: RXN-7571show the reaction diagram
-
-
-
-
natural substrates
3-(imidazol-5-yl)lactate dehydrogenase
(S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+
: histidine metabolism
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR29177show the reaction diagram
: R04186show the reaction diagram
: IMILACTDEHYDROG-RXNshow the reaction diagram
-
-
-
: NAD+ (see R04185)
natural substrates
tryptophan transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR47688show the reaction diagram
: R01161show the reaction diagram
: HISTTRANSAM-RXNshow the reaction diagram
-
-
-
-
natural substrates
histidine transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR47688show the reaction diagram
: R01161show the reaction diagram
: HISTTRANSAM-RXNshow the reaction diagram
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR47688show the reaction diagram
: R01161show the reaction diagram
: HISTTRANSAM-RXNshow the reaction diagram
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR47688show the reaction diagram
: R01161show the reaction diagram
: HISTTRANSAM-RXNshow the reaction diagram
-
-
-
-
natural substrates
kynurenine-oxoglutarate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR47688show the reaction diagram
: R01161show the reaction diagram
: HISTTRANSAM-RXNshow the reaction diagram
-
-
-
-
natural substrates
histidinol-phosphate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: 3-(imidazol-5-yl)lactate salvage,
L-histidine degradation IV
: BR47688show the reaction diagram
: R01161show the reaction diagram
: HISTTRANSAM-RXNshow the reaction diagram
-
-
-
-
natural substrates
methenyltetrahydrofolate cyclohydrolase
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate
: histidine metabolism,
reductive acetyl coenzyme A pathway
: One carbon pool by folate,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: reductive acetyl coenzyme A pathway I (homoacetogenic bacteria),
purine nucleobases degradation I (anaerobic),
folate transformations I,
formaldehyde oxidation VII (THF pathway),
formate assimilation into 5,10-methylenetetrahydrofolate,
folate transformations III (E. coli),
folate transformations II (plants),
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
purine nucleobases degradation II (anaerobic),
L-histidine degradation III
: BR22746show the reaction diagram
: R01655show the reaction diagram
: METHENYLTHFCYCLOHYDRO-RXNshow the reaction diagram
: 74
-
-
-
-
natural substrates
formimidoyltetrahydrofolate cyclodeaminase
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
: histidine metabolism,
purine metabolism
: One carbon pool by folate,
Metabolic pathways
: purine nucleobases degradation I (anaerobic),
L-histidine degradation III,
purine nucleobases degradation II (anaerobic)
: BR3426show the reaction diagram
: R02302show the reaction diagram
: 4.3.1.4-RXNshow the reaction diagram
: 2264
-
-
-
-
natural substrates
putrescine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: histamine degradation
: BR48925show the reaction diagram
: R02150show the reaction diagram
: RXN-9600show the reaction diagram
: 2130
-
-
-
-
natural substrates
primary-amine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: histamine degradation
: BR48925show the reaction diagram
: R02150show the reaction diagram
: RXN-9600show the reaction diagram
: 2130
-
-
-
-
natural substrates
diamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: histamine degradation
: BR48925show the reaction diagram
: R02150show the reaction diagram
: RXN-9600show the reaction diagram
: 2130
-
-
-
-
natural substrates
monoamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: histamine degradation
: BR48925show the reaction diagram
: R02150show the reaction diagram
: RXN-9600show the reaction diagram
: 2130
-
-
-
-
natural substrates
imidazoleacetate 4-monooxygenase
4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: BR36766show the reaction diagram
: R04066show the reaction diagram
: IMIDAZOLEACETATE-4-MONOOXYGENASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: BR22729show the reaction diagram
: R03188show the reaction diagram
: FORMIMINOASPARTATE-DEIMINASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
formimidoylaspartate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: BR22729show the reaction diagram
: R03188show the reaction diagram
: FORMIMINOASPARTATE-DEIMINASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
aspartoacylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
: histidine metabolism
: Histidine metabolism,
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways
: BR22713show the reaction diagram
: R00526show the reaction diagram
: FORMYLASPARTATE-DEFORMYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
formylaspartate deformylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
: histidine metabolism
: Histidine metabolism,
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways
: BR22713show the reaction diagram
: R00526show the reaction diagram
: FORMYLASPARTATE-DEFORMYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
N-formylglutamate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways
: L-histidine degradation II
: BR22707show the reaction diagram
: R00525show the reaction diagram
: N-FORMYLGLUTAMATE-DEFORMYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
formylaspartate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
: histidine metabolism
: Histidine metabolism,
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways
: L-histidine degradation II
: BR22707show the reaction diagram
: R00525show the reaction diagram
: N-FORMYLGLUTAMATE-DEFORMYLASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: L-histidine degradation II
: BR22723show the reaction diagram
: R02286show the reaction diagram
: FORMIMINOGLUTAMATE-DEIMINASE-RXNshow the reaction diagram
: 2251
-
-
-
-
natural substrates
glutamate formimidoyltransferase
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
: histidine metabolism
: Histidine metabolism,
One carbon pool by folate,
Metabolic pathways
: L-histidine degradation III
: BR43944show the reaction diagram, BS451911show the reaction diagram
: R02287show the reaction diagram
: GLUTAMATE-FORMIMINOTRANSFERASE-RXNshow the reaction diagram
: 2252
-
-
-
-
natural substrates
formimidoylglutamase
N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: L-histidine degradation I
: BR26109show the reaction diagram
: R02285show the reaction diagram
: FORMIMINOGLUTAMASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
urocanate hydratase
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: L-histidine degradation III,
L-histidine degradation VI,
L-histidine degradation II,
L-histidine degradation I
: BR428show the reaction diagram
: R02914show the reaction diagram
: UROCANATE-HYDRATASE-RXNshow the reaction diagram
-
-
-
: multi-step reaction covalent intermediate with NAD+
natural substrates, multi-step reaction
histidine ammonia-lyase
L-histidine = urocanate + NH3
: histidine metabolism
: Histidine metabolism,
Metabolic pathways
: L-histidine degradation III,
L-histidine degradation VI,
L-histidine degradation II,
L-histidine degradation I
: BR3425show the reaction diagram
: R01168show the reaction diagram
: HISTIDINE-AMMONIA-LYASE-RXNshow the reaction diagram
: 11319, 1406
-
-
-
-
natural substrates
phosphoribosyl-AMP cyclohydrolase
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR26113show the reaction diagram
: R04037show the reaction diagram
: HISTCYCLOHYD-RXNshow the reaction diagram
-
-
-
-
natural substrates
phosphoribosyl-ATP diphosphatase
1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR22771show the reaction diagram
: R04035show the reaction diagram
: HISTPRATPHYD-RXNshow the reaction diagram
-
-
-
-
natural substrates
ATP phosphoribosyltransferase
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR47479show the reaction diagram
: R01071show the reaction diagram
: ATPPHOSPHORIBOSYLTRANS-RXNshow the reaction diagram
-
-
-
-
natural substrates
ribose-phosphate diphosphokinase
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
: histidine metabolism
: Pentose phosphate pathway,
Purine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Biosynthesis of amino acids
: PRPP biosynthesis
: BR47854show the reaction diagram
: R01049show the reaction diagram
: PRPPSYN-RXNshow the reaction diagram
-
-
-
-
natural substrates
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
N-(5'-Phospho-D-ribosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide = N-(5'-Phospho-D-1-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR225show the reaction diagram, BS1029show the reaction diagram
: R04640show the reaction diagram
: PRIBFAICARPISOM-RXNshow the reaction diagram
: 4302
-
-
-
-
natural substrates
imidazole glycerol phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR51141show the reaction diagram, BR52465show the reaction diagram
: R04558show the reaction diagram
: GLUTAMIDOTRANS-RXNshow the reaction diagram
: 4234
-
-
-
: two-step reaction (see R00256+R12152)
natural substrates
imidazole glycerol-phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR51141show the reaction diagram, BR52465show the reaction diagram
: R04558show the reaction diagram
: GLUTAMIDOTRANS-RXNshow the reaction diagram
: 4234
-
-
-
: two-step reaction (see R00256+R12152)
natural substrates
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR51141show the reaction diagram, BR52465show the reaction diagram
: R04558show the reaction diagram
: GLUTAMIDOTRANS-RXNshow the reaction diagram
: 4234
-
-
-
: two-step reaction (see R00256+R12152)
natural substrates
imidazoleglycerol-phosphate dehydratase
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR404show the reaction diagram
: R03457show the reaction diagram
: IMIDPHOSDEHYD-RXNshow the reaction diagram
-
-
-
-
natural substrates
histidinol-phosphate transaminase
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
: heme metabolism,
histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR47443show the reaction diagram
: R03243show the reaction diagram
: HISTAMINOTRANS-RXNshow the reaction diagram
: 3064
-
-
-
-
natural substrates
histidinol-phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR19199show the reaction diagram
: R03013show the reaction diagram
: HISTIDPHOS-RXNshow the reaction diagram
-
-
-
-
natural substrates
acid phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-histidine biosynthesis
: BR19199show the reaction diagram
: R03013show the reaction diagram
: HISTIDPHOS-RXNshow the reaction diagram
-
-
-
-
natural substrates
L-histidinol + NAD+ = L-histidinal + NADH + H+
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-histidine biosynthesis
: BS371011show the reaction diagram
: R03012show the reaction diagram
: HISTOLDEHYD-RXNshow the reaction diagram
-
-
-
: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163
: This subreaction of RXN-8001 is reversible per [8037463].
natural substrates
histidinol dehydrogenase
L-histidinol + NAD+ = L-histidinal + NADH + H+
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-histidine biosynthesis
: BS371011show the reaction diagram
: R03012show the reaction diagram
: HISTOLDEHYD-RXNshow the reaction diagram
-
-
-
: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163
: This subreaction of RXN-8001 is reversible per [8037463].
natural substrates
L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-histidine biosynthesis
: BS187855show the reaction diagram
: R01163show the reaction diagram
: HISTALDEHYD-RXNshow the reaction diagram
-
-
-
: second step of two-step reaction (R01158, R03012+R01163) following after R03012
: This subreaction of RXN-8001 is physiologically irreversible per [8037463].
natural substrates
histidinol dehydrogenase
L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-histidine biosynthesis
: BS187855show the reaction diagram
: R01163show the reaction diagram
: HISTALDEHYD-RXNshow the reaction diagram
-
-
-
: second step of two-step reaction (R01158, R03012+R01163) following after R03012
: This subreaction of RXN-8001 is physiologically irreversible per [8037463].
natural substrates
histidine decarboxylase
L-histidine = histamine + CO2
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
: histamine biosynthesis
: BR283show the reaction diagram
: R01167show the reaction diagram
: HISTIDINE-DECARBOXYLASE-RXNshow the reaction diagram
: 1405
-
-
-
-
natural substrates
phenylalanine decarboxylase
L-histidine = histamine + CO2
: histidine metabolism
: Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
: histamine biosynthesis
: BR283show the reaction diagram
: R01167show the reaction diagram
: HISTIDINE-DECARBOXYLASE-RXNshow the reaction diagram
: 1405
-
-
-
-
natural substrates