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histidine decarboxylase
Pathways
histidine metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
L-histidine = histamine + CO2
; "show the reaction diagram")
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natural substrates
phenylalanine decarboxylase
L-histidine = histamine + CO2
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natural substrates
L-histidinal + NAD+ + H2O = L-histidine + NADH + H+
; "show the reaction diagram")
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: second step of two-step reaction (R01158, R03012+R01163) following after R03012natural substrates
histidinol dehydrogenase
L-histidinal + NAD+ + H2O = L-histidine + NADH + H+
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: second step of two-step reaction (R01158, R03012+R01163) following after R03012natural substrates
L-histidinol + NAD+ = L-histidinal + NADH + H+
; "show the reaction diagram")
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: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163natural substrates
histidinol dehydrogenase
L-histidinol + NAD+ = L-histidinal + NADH + H+
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: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163natural substrates
histidinol-phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
; "show the reaction diagram")
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natural substrates
acid phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
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natural substrates
histidinol-phosphate transaminase
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
; "show the reaction diagram")
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natural substrates
imidazoleglycerol-phosphate dehydratase
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
; "show the reaction diagram")
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natural substrates
imidazole glycerol phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
; "show the reaction diagram")
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: two-step reaction (see R00256+R12152)natural substrates
imidazole glycerol-phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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: two-step reaction (see R00256+R12152)natural substrates
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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: two-step reaction (see R00256+R12152)natural substrates
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
N-(5'-Phospho-D-ribosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide = N-(5'-Phospho-D-1-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide
; "show the reaction diagram")
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natural substrates
ribose-phosphate diphosphokinase
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
; "show the reaction diagram")
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natural substrates
ATP phosphoribosyltransferase
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate
; "show the reaction diagram")
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natural substrates
phosphoribosyl-ATP diphosphatase
1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate
; "show the reaction diagram")
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natural substrates
phosphoribosyl-AMP cyclohydrolase
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
; "show the reaction diagram")
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natural substrates
histidine ammonia-lyase
L-histidine = urocanate + NH3
; "show the reaction diagram")
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natural substrates
urocanate hydratase
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O
; "show the reaction diagram")
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: multi-step reaction covalent intermediate with NAD+natural substrates, multi-step reaction
imidazolonepropionase
(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+
; "show the reaction diagram")
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natural substrates
formimidoylglutamase
N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide
; "show the reaction diagram")
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natural substrates
glutamate formimidoyltransferase
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
; "show the reaction diagram")
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natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3
; "show the reaction diagram")
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natural substrates
N-formylglutamate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
; "show the reaction diagram")
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natural substrates
formylaspartate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
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natural substrates
aspartoacylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
; "show the reaction diagram")
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natural substrates
formylaspartate deformylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
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natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
; "show the reaction diagram")
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natural substrates
formimidoylaspartate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
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natural substrates
imidazoleacetate 4-monooxygenase
4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O
; "show the reaction diagram")
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natural substrates
putrescine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
; "show the reaction diagram")
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natural substrates
primary-amine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
diamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
monoamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
formimidoyltetrahydrofolate cyclodeaminase
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
; "show the reaction diagram")
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natural substrates
methenyltetrahydrofolate cyclohydrolase
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate
: One carbon pool by folate,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
Biosynthesis of cofactors
: reductive glycine pathway of autotrophic CO2 fixation,folate transformations I,
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria),
purine nucleobases degradation I (anaerobic),
formaldehyde oxidation VII (THF pathway),
formate assimilation into 5,10-methylenetetrahydrofolate,
folate transformations III (E. coli),
folate transformations II (plants),
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
purine nucleobases degradation II (anaerobic),
L-histidine degradation III
; "show the reaction diagram")
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natural substrates
tryptophan transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
; "show the reaction diagram")
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natural substrates
histidine transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
2-aminoadipate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
tyrosine transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
aromatic-amino-acid transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
kynurenine-oxoglutarate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
histidinol-phosphate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
3-(imidazol-5-yl)lactate dehydrogenase
(S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+
; "show the reaction diagram")
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: NAD+ (see R04185)natural substrates
histidine transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
2-aminoadipate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
alanine-glyoxylate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
serine-pyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
phenylalanine(histidine) transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
glutamine-phenylpyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
SPONTANEOUS
H+ + H2O + 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = formyl-isoglutamine
; "show the reaction diagram")
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: non-enzymaticnatural substrates
0.0.0.0
spontaneous reaction
H+ + H2O + 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = formyl-isoglutamine
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: non-enzymaticnatural substrates
H2O + formyl-isoglutamine = isoglutamine + formate
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natural substrates
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spontaneous reaction
H2O + formyl-isoglutamine = isoglutamine + formate
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natural substrates
SPONTANEOUS
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = 4-oxoglutaramate + formate + NH3
; "show the reaction diagram")
incomplete
O2H2
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: multi-step reaction non-enzymatic incomplete reactionnatural substrates, multi-step reaction
0.0.0.0
spontaneous reaction
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = 4-oxoglutaramate + formate + NH3
incomplete
O2H2
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: multi-step reaction non-enzymatic incomplete reactionnatural substrates, multi-step reaction
SPONTANEOUS
H2O + 4-oxoglutaramate = 2-oxoglutarate + NH3 + H+
; "show the reaction diagram")
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: non-enzymatic hydrolysisnatural substrates
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spontaneous reaction
H2O + 4-oxoglutaramate = 2-oxoglutarate + NH3 + H+
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: non-enzymatic hydrolysisnatural substrates
histidine-tRNA ligase
ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis
; "show the reaction diagram")
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natural substrates