Pathways

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BRENDA KEGG MetaCyc

biotin biosynthesis (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
acetyl-CoA carboxytransferase
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
: biotin biosynthesis
: BR52249show the reaction diagram
: R04386show the reaction diagram
: 4081
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: The second step of two-step reaction (R00742) following after R04385
natural substrates
acetyl-CoA carboxylase
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
: biotin biosynthesis
: BR52249show the reaction diagram
: R04386show the reaction diagram
: 4081
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: The second step of two-step reaction (R00742) following after R04385
natural substrates
0.0.0.0
spontaneous reaction
biotin-carboxyl-carrier protein = biotin-carboxyl-carrier protein (dimer)
: biotin biosynthesis
: BR52895show the reaction diagram
generic compounds
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natural substrates, protein
biotin-[biotin carboxyl-carrier protein] ligase
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine
: biotin biosynthesis
: biotin-carboxyl carrier protein assembly
: BR136show the reaction diagram
: BIOTINLIG-RXNshow the reaction diagram
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natural substrates, protein
biotin carboxylase
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
: biotin biosynthesis
: BR135show the reaction diagram
: R04385show the reaction diagram
: 4080
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: The first step of two-step reaction (R00742) subsequently R04386
natural substrates
pyruvate carboxylase
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
: biotin biosynthesis
: BR135show the reaction diagram
: R04385show the reaction diagram
: 4080
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: The first step of two-step reaction (R00742) subsequently R04386
natural substrates
8-amino-7-oxononanoate synthase
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 8-amino-7-oxononanoate biosynthesis IV,
8-amino-7-oxononanoate biosynthesis I,
8-amino-7-oxononanoate biosynthesis II
: BR44048show the reaction diagram
: R10124show the reaction diagram
: RXN-11484show the reaction diagram
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natural substrates, generic, protein
biotin synthase
dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine
: biotin biosynthesis
: BS398860show the reaction diagram
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natural substrates
8-amino-7-oxononanoate synthase
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: biotin biosynthesis from 8-amino-7-oxononanoate I
: BR47441show the reaction diagram, BS406980show the reaction diagram
: R03231show the reaction diagram
: DAPASYN-RXNshow the reaction diagram
: 3057
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natural substrates
adenosylmethionine-8-amino-7-oxononanoate transaminase
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: biotin biosynthesis from 8-amino-7-oxononanoate I
: BR47441show the reaction diagram, BS406980show the reaction diagram
: R03231show the reaction diagram
: DAPASYN-RXNshow the reaction diagram
: 3057
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natural substrates
dethiobiotin synthase
ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: biotin biosynthesis from 8-amino-7-oxononanoate II,
biotin biosynthesis from 8-amino-7-oxononanoate I
: BR128show the reaction diagram
: R03182show the reaction diagram
: DETHIOBIOTIN-SYN-RXNshow the reaction diagram
: 3011
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: two-step reaction (see R12933+R12934)
natural substrates