Pathways

Filter results:
BRENDA KEGG MetaCyc

biotin biosynthesis (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
acetyl-CoA carboxytransferase
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
-
-
: The second step of two-step reaction (R00742) following after R04385
natural substrates
acetyl-CoA carboxylase
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
-
-
: The second step of two-step reaction (R00742) following after R04385
natural substrates
0.0.0.0
spontaneous reaction
biotin-carboxyl-carrier protein = biotin-carboxyl-carrier protein (dimer)
generic compounds
-
-
-
natural substrates, protein
biotin-[biotin carboxyl-carrier protein] ligase
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine
-
-
-
-
natural substrates, protein
biotin carboxylase
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
-
-
-
: The first step of two-step reaction (R00742) subsequently R04386
natural substrates
pyruvate carboxylase
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
-
-
-
: The first step of two-step reaction (R00742) subsequently R04386
natural substrates
8-amino-7-oxononanoate synthase
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
-
-
-
natural substrates, generic, protein
biotin synthase
dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine
-
-
-
-
natural substrates
8-amino-7-oxononanoate synthase
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate
-
-
-
-
natural substrates
adenosylmethionine-8-amino-7-oxononanoate transaminase
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate
-
-
-
-
natural substrates
dethiobiotin synthase
ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
-
-
-
: two-step reaction (see R12933+R12934)
natural substrates