Pathways

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BRENDA KEGG MetaCyc

acetyl CoA biosynthesis (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
pyruvate dehydrogenase system
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
: acetyl CoA biosynthesis
: Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass,
anaerobic energy metabolism (invertebrates, mitochondrial),
photosynthetic 3-hydroxybutanoate biosynthesis (engineered),
1-butanol autotrophic biosynthesis (engineered),
pyruvate fermentation to acetate V,
pyruvate fermentation to acetate II
: BR53165show the reaction diagram
: R00209show the reaction diagram
: PYRUVDEH-RXNshow the reaction diagram
: 523
-
-
-
: multienzyme system multi-step reaction (see R01699+R02569+R07618)
natural substrates, multi-step reaction
pyruvate dehydrogenase (acetyl-transferring)
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
: acetyl CoA biosynthesis
: Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass,
anaerobic energy metabolism (invertebrates, mitochondrial),
photosynthetic 3-hydroxybutanoate biosynthesis (engineered),
1-butanol autotrophic biosynthesis (engineered),
pyruvate fermentation to acetate V,
pyruvate fermentation to acetate II
: BR53165show the reaction diagram
: R00209show the reaction diagram
: PYRUVDEH-RXNshow the reaction diagram
: 523
-
-
-
: multienzyme system multi-step reaction (see R01699+R02569+R07618)
natural substrates, multi-step reaction
oxoglutarate dehydrogenase (succinyl-transferring)
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
: acetyl CoA biosynthesis
: Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass,
anaerobic energy metabolism (invertebrates, mitochondrial),
photosynthetic 3-hydroxybutanoate biosynthesis (engineered),
1-butanol autotrophic biosynthesis (engineered),
pyruvate fermentation to acetate V,
pyruvate fermentation to acetate II
: BR53165show the reaction diagram
: R00209show the reaction diagram
: PYRUVDEH-RXNshow the reaction diagram
: 523
-
-
-
: multienzyme system multi-step reaction (see R01699+R02569+R07618)
natural substrates, multi-step reaction
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
: acetyl CoA biosynthesis
: Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass,
anaerobic energy metabolism (invertebrates, mitochondrial),
photosynthetic 3-hydroxybutanoate biosynthesis (engineered),
1-butanol autotrophic biosynthesis (engineered),
pyruvate fermentation to acetate V,
pyruvate fermentation to acetate II
: BR53165show the reaction diagram
: R00209show the reaction diagram
: PYRUVDEH-RXNshow the reaction diagram
: 523
-
-
-
: multienzyme system multi-step reaction (see R01699+R02569+R07618)
natural substrates, multi-step reaction
acetate-CoA ligase
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
: acetyl CoA biosynthesis
: Glycolysis / Gluconeogenesis,
Pyruvate metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments
: methoxylated aromatic compound degradation II,
pyruvate fermentation to acetate III,
acetate and ATP formation from acetyl-CoA II
: BR64show the reaction diagram
: R00229show the reaction diagram
: ACETATE--COA-LIGASE-ADP-FORMING-RXNshow the reaction diagram
: 180
-
-
-
-
natural substrates
acetate-CoA ligase (ADP-forming)
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
: acetyl CoA biosynthesis
: Glycolysis / Gluconeogenesis,
Pyruvate metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments
: methoxylated aromatic compound degradation II,
pyruvate fermentation to acetate III,
acetate and ATP formation from acetyl-CoA II
: BR64show the reaction diagram
: R00229show the reaction diagram
: ACETATE--COA-LIGASE-ADP-FORMING-RXNshow the reaction diagram
: 180
-
-
-
-
natural substrates
carboxylic acid-CoA ligase (NDP-forming)
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
: acetyl CoA biosynthesis
: Glycolysis / Gluconeogenesis,
Pyruvate metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments
: methoxylated aromatic compound degradation II,
pyruvate fermentation to acetate III,
acetate and ATP formation from acetyl-CoA II
: BR64show the reaction diagram
: R00229show the reaction diagram
: ACETATE--COA-LIGASE-ADP-FORMING-RXNshow the reaction diagram
: 180
-
-
-
-
natural substrates
malonate CoA-transferase
acetyl-CoA + malonate = acetate + malonyl-CoA
: acetyl CoA biosynthesis
: beta-Alanine metabolism
: BR48129show the reaction diagram
: R00743show the reaction diagram
: MALONATE-COA-TRANSFERASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
malonyl-S-ACP:biotin-protein carboxyltransferase
acetyl-CoA + malonate = acetate + malonyl-CoA
: acetyl CoA biosynthesis
: beta-Alanine metabolism
: BR48129show the reaction diagram
: R00743show the reaction diagram
: MALONATE-COA-TRANSFERASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
malonyl-S-ACP decarboxylase
malonyl-CoA = acetyl-CoA + CO2
: acetyl CoA biosynthesis
: beta-Alanine metabolism,
Propanoate metabolism,
Metabolic pathways
: curacin A biosynthesis,
tetracenomycin C biosynthesis
: BR340show the reaction diagram
: R00233show the reaction diagram
: MALONYL-COA-DECARBOXYLASE-RXNshow the reaction diagram
: 750
-
-
-
-
natural substrates
malonyl-CoA decarboxylase
malonyl-CoA = acetyl-CoA + CO2
: acetyl CoA biosynthesis
: beta-Alanine metabolism,
Propanoate metabolism,
Metabolic pathways
: curacin A biosynthesis,
tetracenomycin C biosynthesis
: BR340show the reaction diagram
: R00233show the reaction diagram
: MALONYL-COA-DECARBOXYLASE-RXNshow the reaction diagram
: 750
-
-
-
-
natural substrates
carboxymethylproline synthase
malonyl-CoA = acetyl-CoA + CO2
: acetyl CoA biosynthesis
: beta-Alanine metabolism,
Propanoate metabolism,
Metabolic pathways
: curacin A biosynthesis,
tetracenomycin C biosynthesis
: BR340show the reaction diagram
: R00233show the reaction diagram
: MALONYL-COA-DECARBOXYLASE-RXNshow the reaction diagram
: 750
-
-
-
-
natural substrates
chalcone synthase
malonyl-CoA = acetyl-CoA + CO2
: acetyl CoA biosynthesis
: beta-Alanine metabolism,
Propanoate metabolism,
Metabolic pathways
: curacin A biosynthesis,
tetracenomycin C biosynthesis
: BR340show the reaction diagram
: R00233show the reaction diagram
: MALONYL-COA-DECARBOXYLASE-RXNshow the reaction diagram
: 750
-
-
-
-
natural substrates
malonate-semialdehyde dehydrogenase (acetylating)
3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH + H+
: acetyl CoA biosynthesis
: beta-Alanine metabolism,
Inositol phosphate metabolism,
Propanoate metabolism,
Metabolic pathways,
Carbon metabolism
: propanoyl-CoA degradation II,
beta-alanine degradation II,
myo-inositol degradation I,
beta-alanine degradation I,
acrylate degradation I
: BR29389_WOPThis reaction also exists with phosphate.show the reaction diagram
: R00705show the reaction diagram
: RXN-2902show the reaction diagram, RXN-9958_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1081
-
-
-
: NADP+ (ec 1.2.1.18, see R00706)
natural substrates
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH + H+
: acetyl CoA biosynthesis
: beta-Alanine metabolism,
Inositol phosphate metabolism,
Propanoate metabolism,
Metabolic pathways,
Carbon metabolism
: propanoyl-CoA degradation II,
beta-alanine degradation II,
myo-inositol degradation I,
beta-alanine degradation I,
acrylate degradation I
: BR29389_WOPThis reaction also exists with phosphate.show the reaction diagram
: R00705show the reaction diagram
: RXN-2902show the reaction diagram, RXN-9958_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1081
-
-
-
: NADP+ (ec 1.2.1.18, see R00706)
natural substrates
malonate-semialdehyde dehydrogenase
3-oxopropanoate + NADP+ + H2O = malonate + NADPH + H+
: acetyl CoA biosynthesis
: beta-Alanine metabolism
: BR33729show the reaction diagram
: R01607show the reaction diagram
: MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXNshow the reaction diagram
-
-
-
: NAD+ (see R01604)
natural substrates
succinate-semialdehyde dehydrogenase [NAD(P)+]
3-oxopropanoate + NADP+ + H2O = malonate + NADPH + H+
: acetyl CoA biosynthesis
: beta-Alanine metabolism
: BR33729show the reaction diagram
: R01607show the reaction diagram
: MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXNshow the reaction diagram
-
-
-
: NAD+ (see R01604)
natural substrates
succinate-semialdehyde dehydrogenase (NADP+)
3-oxopropanoate + NADP+ + H2O = malonate + NADPH + H+
: acetyl CoA biosynthesis
: beta-Alanine metabolism
: BR33729show the reaction diagram
: R01607show the reaction diagram
: MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXNshow the reaction diagram
-
-
-
: NAD+ (see R01604)
natural substrates
dihydrolipoyllysine-residue acetyltransferase
acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine
: acetyl CoA biosynthesis
: Glycolysis / Gluconeogenesis,
Citrate cycle (TCA cycle),
Pyruvate metabolism
: BR43982show the reaction diagram
: R02569show the reaction diagram
-
-
-
: pyruvate dehydrogenase complex:dihydrolipoyllysine-residue acetyltransferase a part of multi-step reaction (see R00209, R01699+R02569+R07618) following after R01699
natural substrates, protein
pyruvate dehydrogenase system
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
: acetyl CoA biosynthesis
: BR33749show the reaction diagram
-
-
-
-
natural substrates, protein
pyruvate dehydrogenase (acetyl-transferring)
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
: acetyl CoA biosynthesis
: BR33749show the reaction diagram
-
-
-
-
natural substrates, protein
dihydrolipoyl dehydrogenase
protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+
: acetyl CoA biosynthesis
: Glycine, serine and threonine metabolism,
Glycolysis / Gluconeogenesis,
Citrate cycle (TCA cycle),
Valine, leucine and isoleucine degradation,
Pyruvate metabolism,
Propanoate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of cofactors
: BR36970show the reaction diagram
: R03815show the reaction diagram, R07618show the reaction diagram, R08550show the reaction diagram
: 1.8.1.4-RXNshow the reaction diagram
: 9140
-
-
-
: a part step of glycine cleavage system (see R01221, R03425+R04125+R03815); Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase; general reaction (see R03815 and R07618)
natural substrates, multi-step reaction
acetyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
(S)-methylmalonyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
ADP-dependent short-chain-acyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
palmitoyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
acyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
4-hydroxybenzoyl-CoA thioesterase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
phenylacetyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
fluoroacetyl-CoA thioesterase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
acetyl-CoA C-acyltransferase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
carboxymethylproline synthase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
homoserine O-acetyltransferase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
hydroxymethylglutaryl-CoA synthase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates
2-isopropylmalate synthase
acetyl-CoA + H2O = CoA + acetate
: acetate fermentation,
acetyl CoA biosynthesis
: Pyruvate metabolism,
Metabolic pathways
: BR11726show the reaction diagram
: R00227show the reaction diagram
: ACETYL-COA-HYDROLASE-RXNshow the reaction diagram
: 171
-
-
-
-
natural substrates