Pathways

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BRENDA KEGG MetaCyc

4-hydroxymandelate degradation (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
aldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments
: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR51337show the reaction diagram
: R01294show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXNshow the reaction diagram, RXN-13394show the reaction diagram
: 1509
-
-
-
-
natural substrates
aldehyde dehydrogenase [NAD(P)+]
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments
: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR51337show the reaction diagram
: R01294show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXNshow the reaction diagram, RXN-13394show the reaction diagram
: 1509
-
-
-
-
natural substrates
vanillin dehydrogenase
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments
: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR51337show the reaction diagram
: R01294show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXNshow the reaction diagram, RXN-13394show the reaction diagram
: 1509
-
-
-
-
natural substrates
benzaldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments
: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR51337show the reaction diagram
: R01294show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXNshow the reaction diagram, RXN-13394show the reaction diagram
: 1509
-
-
-
-
natural substrates
4-hydroxybenzaldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments
: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR51337show the reaction diagram
: R01294show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXNshow the reaction diagram, RXN-13394show the reaction diagram
: 1509
-
-
-
-
natural substrates
benzaldehyde dehydrogenase (NAD+)
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
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-
natural substrates
aryl-aldehyde dehydrogenase
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
-
-
natural substrates
aldehyde dehydrogenase (NAD+)
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
-
-
natural substrates
4-hydroxybenzaldehyde dehydrogenase (NAD+)
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
-
-
natural substrates
salicylaldehyde dehydrogenase
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
-
-
natural substrates
vanillin dehydrogenase
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
-
-
natural substrates
4-hydroxybenzaldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+
: 4-hydroxymandelate degradation
: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)
: BR29420show the reaction diagram
: R01293show the reaction diagram
: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXNshow the reaction diagram, RXN-13394_WOPThis reaction also exists with phosphate.show the reaction diagram
: 1508
-
-
-
-
natural substrates
mandelate racemase
p-hydroxy-D-mandelate = p-hydroxy-L-mandelate
: 4-hydroxymandelate degradation
: Microbial metabolism in diverse environments
: 4-hydroxymandelate degradation
: BS186625show the reaction diagram
: R04161show the reaction diagram
: HYDROXY-MANDELATE-RACEMASE-RXNshow the reaction diagram
-
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natural substrates
4-hydroxybenzoate 3-monooxygenase
4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: 4-coumarate degradation (aerobic),
polybrominated dihydroxylated diphenyl ethers biosynthesis,
spongiadioxin C biosynthesis,
bisphenol A degradation,
4-methylphenol degradation to protocatechuate,
4-chlorobenzoate degradation,
4-hydroxymandelate degradation
: BR36759show the reaction diagram
: R01298show the reaction diagram
: 1.14.13.33-RXNshow the reaction diagram, 4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXNshow the reaction diagram
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: NADH (ec 1.14.13.33, see R1296)
natural substrates
4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: 4-coumarate degradation (aerobic),
polybrominated dihydroxylated diphenyl ethers biosynthesis,
spongiadioxin C biosynthesis,
bisphenol A degradation,
4-methylphenol degradation to protocatechuate,
4-chlorobenzoate degradation,
4-hydroxymandelate degradation
: BR36759show the reaction diagram
: R01298show the reaction diagram
: 1.14.13.33-RXNshow the reaction diagram, 4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXNshow the reaction diagram
-
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: NADH (ec 1.14.13.33, see R1296)
natural substrates
protocatechuate 3,4-dioxygenase
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Polycyclic aromatic hydrocarbon degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: protocatechuate degradation II (ortho-cleavage pathway)
: BR40477show the reaction diagram
: R01631show the reaction diagram
: PROTOCATECHUATE-34-DIOXYGENASE-RXNshow the reaction diagram
-
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natural substrates
4-carboxymuconolactone decarboxylase
(R)-2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: protocatechuate degradation II (ortho-cleavage pathway)
: BR3361show the reaction diagram, BS18492show the reaction diagram
: R03470show the reaction diagram
: 4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXNshow the reaction diagram
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natural substrates
3-carboxy-cis,cis-muconate cycloisomerase
cis,cis-butadiene-1,2,4-tricarboxylate = 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: protocatechuate degradation II (ortho-cleavage pathway)
: BR260show the reaction diagram, BR263show the reaction diagram
: R03307show the reaction diagram, R03308show the reaction diagram
: 5.5.1.2-RXNshow the reaction diagram, CARBOXY-CISCIS-MUCONATE-CYCLASE-RXNshow the reaction diagram
: 3123
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natural substrates
Carboxy-cis,cis-muconate cyclase
cis,cis-butadiene-1,2,4-tricarboxylate = 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: protocatechuate degradation II (ortho-cleavage pathway)
: BR260show the reaction diagram, BR263show the reaction diagram
: R03307show the reaction diagram, R03308show the reaction diagram
: 5.5.1.2-RXNshow the reaction diagram, CARBOXY-CISCIS-MUCONATE-CYCLASE-RXNshow the reaction diagram
: 3123
-
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natural substrates
3-oxoadipate enol-lactonase
3-oxoadipate enol-lactone + H2O = 3-oxoadipate
: 4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: protocatechuate degradation II (ortho-cleavage pathway),
catechol degradation to beta-ketoadipate
: BR11711show the reaction diagram
: R02991show the reaction diagram
: 3-OXOADIPATE-ENOL-LACTONASE-RXNshow the reaction diagram
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natural substrates
3-oxoadipate CoA-transferase
succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA
: aerobic toluene degradation,
4-hydroxymandelate degradation
: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: 3-oxoadipate degradation
: BR48131show the reaction diagram
: R02990show the reaction diagram
: 3-OXOADIPATE-COA-TRANSFERASE-RXNshow the reaction diagram
: 2842
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natural substrates