New release (2023.1) online!
Learn more about features, functions and data:
BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
Results per page 
  • 10 results
  • 50 results
  • 100 results
  • 500 results
  • 100000 results
Show or hide columns 
  • EC Number
  • Reaction
  • Pathways
  • Reaction IDs
  • Stoichiometry Check
  • Missing Substrate
  • Missing Product
  • Commentary
  • Remark
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
argininosuccinate synthase
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate
: urea cycle
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine biosynthesis IV (archaea),
L-arginine biosynthesis I (via L-ornithine),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR142show the reaction diagram, BS408483show the reaction diagram
: R01954show the reaction diagram
: ARGSUCCINSYN-RXNshow the reaction diagram
: 572
-
-
citrullinase
L-citrulline + H2O = L-ornithine + CO2 + NH3
: urea cycle
: BR19238show the reaction diagram, BS116217show the reaction diagram
: R00665show the reaction diagram
: CITRULLINASE-RXNshow the reaction diagram
-
-
beta-ureidopropionase
L-citrulline + H2O = L-ornithine + CO2 + NH3
: urea cycle
: BR19238show the reaction diagram, BS116217show the reaction diagram
: R00665show the reaction diagram
: CITRULLINASE-RXNshow the reaction diagram
-
-
protein-arginine deiminase
L-arginine + H2O = L-citrulline + NH3
: arginine metabolism
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine degradation V (arginine deiminase pathway)
: BR22730show the reaction diagram, BS369889show the reaction diagram
: R00552show the reaction diagram
: ARGININE-DEIMINASE-RXNshow the reaction diagram
: 97
-
-
arginine deiminase
L-arginine + H2O = L-citrulline + NH3
: arginine metabolism
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine degradation V (arginine deiminase pathway)
: BR22730show the reaction diagram, BS369889show the reaction diagram
: R00552show the reaction diagram
: ARGININE-DEIMINASE-RXNshow the reaction diagram
: 97
-
-
dimethylargininase
Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline
-
: BR29520show the reaction diagram
: R02513show the reaction diagram
: DIMETHYLARGININASE-RXNshow the reaction diagram
: 2438
-
-
nitric-oxide synthase (flavodoxin)
2 L-arginine + 3 reduced flavodoxin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H2O
: Arginine biosynthesis,
Metabolic pathways
: BR40515show the reaction diagram
: R11711show the reaction diagram
: RXN-13568show the reaction diagram
-
: two-step reaction (see R11712+R11713)
ornithine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
: BR43950show the reaction diagram, BS140887show the reaction diagram
: R01398show the reaction diagram
: ORNCARBAMTRANSFER-RXNshow the reaction diagram
: 98
-
-
putrescine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
: BR43950show the reaction diagram, BS140887show the reaction diagram
: R01398show the reaction diagram
: ORNCARBAMTRANSFER-RXNshow the reaction diagram
: 98
-
-
agmatine deiminase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
: BR43950show the reaction diagram, BS140887show the reaction diagram
: R01398show the reaction diagram
: ORNCARBAMTRANSFER-RXNshow the reaction diagram
: 98
-
-
acetylornithine deacetylase
N-acetyl-L-citrulline + H2O = L-citrulline + acetate
: arginine metabolism
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of amino acids
: L-arginine biosynthesis III (via N-acetyl-L-citrulline)
: BR48939show the reaction diagram, BS394032show the reaction diagram
: R09107show the reaction diagram
: RXN-7933show the reaction diagram
-
-
acetylcitrulline deacetylase
N-acetyl-L-citrulline + H2O = L-citrulline + acetate
: arginine metabolism
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of amino acids
: L-arginine biosynthesis III (via N-acetyl-L-citrulline)
: BR48939show the reaction diagram, BS394032show the reaction diagram
: R09107show the reaction diagram
: RXN-7933show the reaction diagram
-
-
2 Nomega-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O
: Arginine and proline metabolism,
Metabolic pathways
: nitric oxide biosynthesis III (bacteria)
: BR50159show the reaction diagram
: R11713show the reaction diagram
: RXN-13567show the reaction diagram
-
: the second step of two-step reaction (see R11711, R11712+R11713)
nitric-oxide synthase (flavodoxin)
2 Nomega-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O
: Arginine and proline metabolism,
Metabolic pathways
: nitric oxide biosynthesis III (bacteria)
: BR50159show the reaction diagram
: R11713show the reaction diagram
: RXN-13567show the reaction diagram
-
: the second step of two-step reaction (see R11711, R11712+R11713)
nitric-oxide synthase (NADPH)
2 Nomega-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O
: Arginine and proline metabolism,
Metabolic pathways
: nitric oxide biosynthesis I (plants)
: BR50160show the reaction diagram, BS289236show the reaction diagram
: R00111show the reaction diagram
: RXN-13565show the reaction diagram
-
: the latter part of multi-step reaction (see R00557, R00558+R00111) following after R00558 NADH (see R10108)
2 Nomega-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O
: Arginine and proline metabolism,
Metabolic pathways
: nitric oxide biosynthesis I (plants)
: BR50160show the reaction diagram, BS289236show the reaction diagram
: R00111show the reaction diagram
: RXN-13565show the reaction diagram
-
: the latter part of multi-step reaction (see R00557, R00558+R00111) following after R00558 NADH (see R10108)
nitric-oxide synthase (NADPH)
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: nitric oxide biosynthesis II (mammals)
: BR52111show the reaction diagram, BS394886show the reaction diagram
: R00557show the reaction diagram
: NITRIC-OXIDE-SYNTHASE-RXNshow the reaction diagram
: 969
-
: multi-step reaction (see R00558+R00111) NADH (see R10106)
nitric-oxide synthase (flavodoxin)
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: nitric oxide biosynthesis II (mammals)
: BR52111show the reaction diagram, BS394886show the reaction diagram
: R00557show the reaction diagram
: NITRIC-OXIDE-SYNTHASE-RXNshow the reaction diagram
: 969
-
: multi-step reaction (see R00558+R00111) NADH (see R10106)
ornithine carbamoyltransferase
arsenate + L-citrulline = carbamoylarsenate + L-ornithine
-
: BS320103show the reaction diagram
: 8025
-
-
arginine deiminase
Nomega-amino-Arg + H2O = L-citrulline + hydrazine
-
: BS382422show the reaction diagram
: 7744
-
-
dimethylargininase
Nomega-methyl-Arg + H2O = L-citrulline + methylamine
-
: BS382423show the reaction diagram
: 14599, 7743
-
-
arginine deiminase
Nomega-methyl-Arg + H2O = L-citrulline + methylamine
-
: BS382423show the reaction diagram
: 14599, 7743
-
-
2 L-Arginine + 3 NADH + 3 H+ + 4 Oxygen <=> 2 L-Citrulline + 2 Nitric oxide + 3 NAD+ + 4 H2O
-
: R10106show the reaction diagram
-
: multi-step reaction (see R10107+R10108) NADPH (see R00557)
2 N(omega)-Hydroxyarginine + NADH + H+ + 2 Oxygen <=> 2 L-Citrulline + 2 Nitric oxide + NAD+ + 2 H2O
-
: R10108show the reaction diagram
-
: the latter part of multi-step reaction (see R10106, R10107+R10108) NADPH (see R00111)
L-citrulline + H2O = L-ornithine + carbamate
-
: RXN-23370show the reaction diagram
-
-
L-citrulline = L-citrulline
-
: TRANS-RXN-227show the reaction diagram
-
-
agmatine deiminase
agmatine + ornithine + H2O + phosphate = putrescine + citrulline + NH3 + phosphate
-
: BS140888show the reaction diagram
-
-
L-amino-acid oxidase
L-citrulline + H2O + O2 = N-carbamoyl-5-amino-2-oxopentanoic acid + NH3 + H2O2
-
: BS363794show the reaction diagram
-
-
nitric-oxide synthase (NADPH)
Ngamma-hydroxy-L-arginine + H2O2 = citrulline + Ndelta-cyanoornithine + NO2- + NO3-
-
: BS289237show the reaction diagram
incomplete
-
nitric-oxide synthase (flavodoxin)
2 L-arginine + 3 tetrahydrofolate + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized tetrahydrofolate + 4 H2O
-
: BS438667show the reaction diagram
-
-
nitric-oxide synthase (flavodoxin)
2 L-arginine + 3 tetrahydrobiopterin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized tetrahydrobiopterin + 4 H2O
-
: BS438666show the reaction diagram
-
-
nitric-oxide synthase (flavodoxin)
2 Nomega-hydroxy-L-arginine + tetrahydrobiopterin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized tetrahydrobiopterin + 2 H2O
-
: BS438668show the reaction diagram
-
-
nitric-oxide synthase (NADPH)
Nomega-hydroxy-L-arginine + 2',3'-dialdehyde-NADPH + H+ + O2 = 2 L-citrulline + nitric oxide + 2',3'-dialdehyde-NADP+ + H2O
-
: BS451278show the reaction diagram
incomplete
-
dimethylargininase
NG-monomethyl-L-arginine + H2O = citrulline + methylamine
-
: BS190018show the reaction diagram
-
-
D-octopine dehydrogenase
L-Citrulline + pyruvate + NADPH = N2-(D-1-Carboxyethyl)-L-citrulline + NADP+ + H2O
-
: BS6367show the reaction diagram
-
-
bleomycin hydrolase
citrulline-4-methylcoumarin 7-amide + H2O = citrulline + 7-amino-4-methylcoumarin
-
: BS37040show the reaction diagram
-
-
cathepsin H
citrulline-4-methylcoumaryl-7-amide + H2O = citrulline + 7-amino-4-methylcoumarin
-
: BS355554show the reaction diagram
-
-
bleomycin hydrolase
citrulline-4-methylcoumaryl-7-amide + H2O = citrulline + 7-amino-4-methylcoumarin
-
: BS355554show the reaction diagram
-
-
dimethylargininase
S-methyl-L-thiocitrulline + H2O = methanethiol + L-citrulline
-
: BS385696show the reaction diagram
-
-
tryptophanyl aminopeptidase
L-citrulline + H2O = (2S)-2-amino-5-(carboxyamino)pentanoic acid + NH3
-
: BS382111show the reaction diagram
-
-
amino-acid racemase
L-Citrulline = D-Citrulline
-
: BS837show the reaction diagram
-
-
arginine racemase
L-Citrulline = D-Citrulline
-
: BS837show the reaction diagram
-
-
7.4.2.1
ABC-type polar-amino-acid transporter
ATP + H2O + L-citrulline-[L-citrulline-binding protein][side 1] = ADP + phosphate + L-citrulline[side 2] + [L-citrulline-binding protein][side 1]
-
: BS445053show the reaction diagram
n.a.
-
7.4.2.1
ABC-type polar-amino-acid transporter
ATP + H2O + L-citrulline/out = ADP + phosphate + L-citrulline/in
-
: BS396502show the reaction diagram
-
-
arginine-tRNA ligase
ATP + L-citrulline + tRNACCCG = AMP + diphosphate + L-citryl-tRNACCCG
-
: BS428275show the reaction diagram
generic compounds
-
argininosuccinate synthase
dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate
-
: BS715show the reaction diagram
-
-
gamma-glutamyltransferase
5-L-glutamyl-4-nitroanilide + citrulline = 4-nitroaniline + 5-L-glutamyl-citrulline
-
: BS321636show the reaction diagram
-
-
bleomycin hydrolase
citrulline-beta-naphthylamide + H2O = citrulline + beta-naphthylamine
-
: BS404682show the reaction diagram
-
-
tryptophan-phenylpyruvate transaminase
phenylpyruvate + L-citrulline = phenylalanine + 2-oxo-5-ureido-pentanoate
-
: BS356443show the reaction diagram
-
-
carbamoyl-phosphate synthase (ammonia)
Hydrogencarbonate + L-Ornithine + 2 ATP + NH3 <=> L-Citrulline + 2 ADP + 2 Phosphate + H2O
-
: 9636
incomplete
-