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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
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  • EC Number
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EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
vitamin D 25-hydroxylase
vitamin D2 + O2 + NADPH + H+ = 25-hydroxy-vitamin D2 + NADP+ + H2O
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SPONTANEOUS
Ergosterol + hn <=> Vitamin D2
n.a.
: Ultraviolet light (UV) non-enzymatic
ergosterol + UV light = vitamin D2
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n.a.
Vitamin D2 (ergocalciferol) is formed from ERGOSTEROL during UV exposure, as a result of the photochemical cleavage of the B ring of ergosterol. The cleavage forms the intermediate pre-vitamin D2, which then undergoes thermal re-arrangement to vitamin D2 |CITS: [Perera10]|.
vitamin D 25-hydroxylase
calciferol + O2 + [reduced NADPH-hemoprotein reductase] = 25-hydroxy-vitamin D2 + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol monooxygenase (side-chain-cleaving)
vitamin D2 + reduced adrenodoxin + O2 = 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + H2O
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generic compounds
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vitamin D 1,25-hydroxylase
vitamin D2 + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 25-hydroxyvitamin D2 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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generic compounds
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unspecific peroxygenase
ergocalciferol + H2O2 = 25-hydroxyergocalciferol + H2O
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