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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
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  • EC Number
  • Reaction
  • Pathways
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  • Stoichiometry Check
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  • Commentary
  • Remark
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
flavin-containing monooxygenase
tamoxifen + NADPH + O2 = tamoxifen N-oxide + NADP+ + H2O
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: FMO1,FMO3
Tamoxifen + NADPH + Oxygen + H+ <=> Hydroxytamoxifen + NADP+ + H2O
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: CYP2D6, CYP2C9
unspecific monooxygenase
Tamoxifen + NADPH + Oxygen + H+ <=> Hydroxytamoxifen + NADP+ + H2O
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: CYP2D6, CYP2C9
Tamoxifen <=> N-Desmethyltamoxifen
incomplete
: CYP3A4: N-demethylation incomplete reaction
Tamoxifen + NADPH + Oxygen + H+ <=> alpha-Hydroxytamoxifen + NADP+ + H2O
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: CYP3A4
unspecific monooxygenase
tamoxifen + reduced [NADPH-hemoprotein reductase] + dioxygen = afimoxifene + oxidized [NADPH-hemoprotein reductase] + H2O
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generic compounds
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glucuronosyltransferase
tamoxifen + UDP-alpha-D-glucuronate = tamoxifen-N-glucuronate + UDP
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incomplete
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glucuronosyltransferase
UDP-glucuronate + tamoxifen = UDP + tamoxifen N-beta-D-glucuronoside
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-
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glucuronosyltransferase
UDP-D-glucuronate + tamoxifen + H+ = UDP + tamoxifen beta-D-glucuronoside
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-
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estrone sulfotransferase
3'-phosphoadenylyl sulfate + tamoxifen = adenosine 3',5'-bisphosphate + tamoxifen sulfate
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n.a.
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7.6.2.2
ABC-type xenobiotic transporter
ATP + H2O + tamoxifen[side 1] = ADP + phosphate + tamoxifen[side 2]
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