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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
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  • EC Number
  • Reaction
  • Pathways
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  • Stoichiometry Check
  • Missing Substrate
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  • Commentary
  • Remark
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
thiamine oxidase
thiamine + 2 O2 + H2O = thiamine acetic acid + 2 H2O2
-
: BR36738show the reaction diagram
: R02132show the reaction diagram
: THIAMIN-OXIDASE-RXNshow the reaction diagram
-
: two-step reaction (see R00033+R00072)
thiamine pyridinylase
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole
: Thiamine metabolism,
Metabolic pathways
: BR47405show the reaction diagram
: R02863show the reaction diagram
: THIAMIN-PYRIDINYLASE-RXNshow the reaction diagram
-
-
thiamine kinase
ATP + thiamine = ADP + thiamine phosphate
: vitamin B1 metabolism
: Thiamine metabolism,
Metabolic pathways
: thiamine diphosphate salvage I
: BR47814show the reaction diagram
: R02134show the reaction diagram
: THIKIN-RXNshow the reaction diagram
-
-
thiamine diphosphokinase
ATP + thiamine = AMP + thiamine diphosphate
: vitamin B1 metabolism
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine diphosphate salvage III
: BR47855show the reaction diagram
: R00619show the reaction diagram
: THIAMIN-PYROPHOSPHOKINASE-RXNshow the reaction diagram
-
-
aminopyrimidine aminohydrolase
thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
: vitamin B1 metabolism
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: thiamine diphosphate salvage IV (yeast)
: BR49840show the reaction diagram
: R02133show the reaction diagram
: THIAMINASE-RXNshow the reaction diagram
-
-
alkaline phosphatase
thiamine phosphate + H2O = thiamine + phosphate
: vitamin B1 metabolism
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)
: BR51620show the reaction diagram
: R02135show the reaction diagram
: RXNQT-4191show the reaction diagram
-
-
thiamine phosphate phosphatase
thiamine phosphate + H2O = thiamine + phosphate
: vitamin B1 metabolism
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)
: BR51620show the reaction diagram
: R02135show the reaction diagram
: RXNQT-4191show the reaction diagram
-
-
acid phosphatase
thiamine phosphate + H2O = thiamine + phosphate
: vitamin B1 metabolism
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine diphosphate salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes)
: BR51620show the reaction diagram
: R02135show the reaction diagram
: RXNQT-4191show the reaction diagram
-
-
thiamine oxidase
Thiamine + Oxygen <=> Hydrogen peroxide + Thiamine aldehyde
: Thiamine metabolism,
Metabolic pathways
: R00033show the reaction diagram
-
: first step of two-step reaction (see R02132, R00033+R00072) subsequently R00072 (without release of thiamine aldehyde from enzyme)
SPONTANEOUS
Thiamine <=> N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
: Thiamine metabolism,
Metabolic pathways
: R11314show the reaction diagram
incomplete
: incomplete reaction non-enzymatic
7.6.2.15
ABC-type thiamine transporter
ATP + thiamine + H2O = ADP + phosphate + thiamine + H+
-
: ABC-32-RXNshow the reaction diagram
-
-
thiamine pyridinylase
thiamine + proline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyrrolidine-2-carboxylic acid
-
: BS353790show the reaction diagram
-
-
thiamine pyridinylase
thiamine + imidazole = 4-methyl-5-(2-hydroxyethyl)-thiazole + 5-(1H-imidazol-1-yl-methyl)-2-methylpyrimidin-4-amine
-
: BS353793show the reaction diagram
-
-
thiamine pyridinylase
thiamine + o-aminobenzoic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 2-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
-
: BS353807show the reaction diagram
incomplete
-
thiamine pyridinylase
thiamine + beta-picoline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]beta-picolinium
-
: BS353796show the reaction diagram
-
-
thiamine pyridinylase
thiamine + quinoline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]quinolinium
-
: BS353794show the reaction diagram
-
-
thiamine pyridinylase
thiamine + p-phenylene diamine = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(4-aminophenyl)amine
-
: BS353800show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 2-hydroxyaniline = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(2-hydroxyphenyl)amine
-
: BS353804show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 6-aminohexanoic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 6-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]hexanoic acid
-
: BS353810show the reaction diagram
-
-
thiamine pyridinylase
thiamine + gamma-picoline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]gamma-picolinium
-
: BS353797show the reaction diagram
-
-
thiamine pyridinylase
thiamine + alpha-picoline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]alpha-picolinium
-
: BS353795show the reaction diagram
-
-
thiamine pyridinylase
thiamine + hydroxyproline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]4-hydroxypyrrolidine-2-carboxylic acid
-
: BS353791show the reaction diagram
-
-
thiamine pyridinylase
thiamine + o-phenylene diamine = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(2-aminophenyl)amine
-
: BS353798show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 4-hydroxyaniline = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(4-hydroxyphenyl)amine
-
: BS353806show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 3-methylbenzeneamine = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(3-methylphenyl)amine
-
: BS353802show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 2-pyridinecarboxylic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxypyridinium
-
: BS353812show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 2-methylbenzeneamine = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(2-methylphenyl)amine
-
: BS353801show the reaction diagram
-
-
thiamine pyridinylase
thiamine + m-aminobenzoic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 3-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
-
: BS353808show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 3-hydroxyaniline = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(3-hydroxyphenyl)amine
-
: BS353805show the reaction diagram
-
-
thiamine pyridinylase
thiamine + aniline = 5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
: BS353788show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 4-methylbenzeneamine = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(4-methylphenyl)amine
-
: BS353803show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 4-pyridinecarboxylic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-carboxypyridinium
-
: BS353814show the reaction diagram
-
-
thiamine pyridinylase
thiamine + veratrylamine = bis-(4-amino-2-methyl)pyrimidinyl-3,4-dimethoxybenzylamine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
: BS353815show the reaction diagram
incomplete
-
thiamine pyridinylase
thiamine + 3-pyridinecarboxylic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-carboxypyridinium
-
: BS353813show the reaction diagram
-
-
thiamine pyridinylase
thiamine + 4-nitrothiophenolate = 4-methyl-5-(2-hydroxyethyl)thiazole + 2-methyl-5[[(4-nitrophenyl)sulfanyl]methyl]pyrimidin-4-amine
-
: BS398415show the reaction diagram
-
-
thiamine pyridinylase
thiamine + p-aminobenzoic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 4-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
-
: BS353809show the reaction diagram
-
-
thiamine pyridinylase
thiamine + m-phenylene diamine = 4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(3-aminophenyl)amine
-
: BS353799show the reaction diagram
-
-
thiamine pyridinylase
thiamine + L-cysteine = 4-methyl-5-(2-hydroxyethyl)-thiazole + 2-[[(4-amino-2-ethylpyrimidin-5-yl)methyl]amino]-3-mercaptopropanoic acid
-
: BS353832show the reaction diagram
incomplete
-
7.6.2.15
ABC-type thiamine transporter
ATP + H2O + thiamine-[thiamine-binding protein][side 1] = ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1]
-
: BR53056show the reaction diagram
n.a.
-
thiamine diphosphokinase
UTP + thiamine = UMP + thiamine diphosphate
-
: BS358311show the reaction diagram
-
-
thiamine diphosphokinase
GTP + thiamine = GMP + thiamine diphosphate
-
: BS358313show the reaction diagram
-
-
thiamine diphosphokinase
CTP + thiamine = CMP + thiamine diphosphate
-
: BS358312show the reaction diagram
-
-
apyrase
thiamine diphosphate + 2 H2O = thiamine + 2 phosphate
-
: BS141374show the reaction diagram
-
-
acid phosphatase
thiamine diphosphate + 2 H2O = thiamine + 2 phosphate
-
: BS141374show the reaction diagram
-
-
nucleotide diphosphatase
thiamine diphosphate + H2O = thiamine + diphosphate
-
: BS456827show the reaction diagram
-
-