New release (2023.1) online!
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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
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  • EC Number
  • Reaction
  • Pathways
  • Reaction IDs
  • Stoichiometry Check
  • Missing Substrate
  • Missing Product
  • Commentary
  • Remark
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
glutamate carboxypeptidase
methotrexate + H2O = 4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate
-
-
-
aldehyde oxidase
methotrexate + H2O + O2 = 7-hydroxymethotrexate + H2O2
-
-
-
carboxypeptidase A
methotrexate-alpha-(1-naphthyl)alanine + H2O = methotrexate + (1-naphthyl)alanine
-
-
-
carboxypeptidase A2
methotrexate-alpha-(1-naphthyl)alanine + H2O = methotrexate + (1-naphthyl)alanine
-
-
-
Glutamate carboxypeptidase II
methotrexate triglutamate + H2O = L-Glu + methotrexate
-
incomplete
-
tetrahydrofolate synthase
ATP + methotrexate + 3,3-difluoroglutamate = ADP + phosphate + methotrexyl-3,3-difluoroglutamate
-
-
-
7.6.2.2
ABC-type xenobiotic transporter
methotrexate/in + ATP + H2O = methotrexate/out + ADP + phosphate
-
-
-
tetrahydrofolate synthase
ATP + methotrexate + L-glutamate = ADP + phosphate + L-glutamyl-methotrexate
-
-
-
carboxypeptidase A
methotrexate-alpha-phenylalanine + H2O = methotrexate + phenylalanine
-
-
-
carboxypeptidase A2
methotrexate-alpha-phenylalanine + H2O = methotrexate + phenylalanine
-
-
-
carboxypeptidase A
methotrexate-phenylalanine + H2O = methotrexate + phenylalanine
-
-
-