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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
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  • EC Number
  • Reaction
  • Pathways
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  • Stoichiometry Check
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  • Commentary
  • Remark
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
acyl-CoA (8-3)-desaturase
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = arachidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
: Biosynthesis of unsaturated fatty acids,
Fatty acid metabolism
: arachidonate biosynthesis III (6-desaturase, mammals),
arachidonate biosynthesis V (8-detaturase, mammals)
: BR51508show the reaction diagram, BS433635show the reaction diagram
: R11059show the reaction diagram
: RXN-16064show the reaction diagram
-
-
acyl-lipid (8-3)-desaturase
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+ = arachidonic acid + ferricytochrome b5 + H2O
: arachidonate biosynthesis
: BS432765show the reaction diagram
: RXN-23441show the reaction diagram
generic compounds
: For modeling sake, this reaction is shown with free fatty acids, even though in the cell the true substrates are the CoA-derivatives of these acids.
acyl-CoA (8-3)-desaturase
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+ = arachidonic acid + ferricytochrome b5 + H2O
: arachidonate biosynthesis
: BS432765show the reaction diagram
: RXN-23441show the reaction diagram
generic compounds
: For modeling sake, this reaction is shown with free fatty acids, even though in the cell the true substrates are the CoA-derivatives of these acids.
palmitoyl-CoA hydrolase
8,11,14-Eicosatrienoyl-CoA + H2O <=> CoA + Dihomo-gamma-linolenate
: Biosynthesis of unsaturated fatty acids
: R08182show the reaction diagram
: RXN-13435show the reaction diagram
-
-
(11Z,14Z)-Icosadienoyl-CoA + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 8,11,14-Eicosatrienoyl-CoA + 2 Ferricytochrome b5 + 2 H2O
: Biosynthesis of unsaturated fatty acids,
Fatty acid metabolism
: arachidonate biosynthesis V (8-detaturase, mammals)
: R12171show the reaction diagram
: RXN-17105show the reaction diagram
n.a.
-
acyl-CoA 6-desaturase
(11Z,14Z)-Icosadienoyl-CoA + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 8,11,14-Eicosatrienoyl-CoA + 2 Ferricytochrome b5 + 2 H2O
: Biosynthesis of unsaturated fatty acids,
Fatty acid metabolism
: arachidonate biosynthesis V (8-detaturase, mammals)
: R12171show the reaction diagram
: RXN-17105show the reaction diagram
n.a.
-
very-long-chain enoyl-CoA reductase
(2E,8Z,11Z,14Z)-icosatetraenoyl-CoA + NADH + H+ = dihomo gamma-linolenoyl-CoA + NAD+
: arachidonate biosynthesis III (6-desaturase, mammals),
arachidonate biosynthesis I (6-desaturase, lower eukaryotes)
: RXN-12971show the reaction diagram
-
-
oleoyl-[acyl-carrier-protein] hydrolase
dihomo gamma linolenoyl [acp] + H2O = di-homo-gamma-linolenate + soluble [acyl-carrier protein] + H+
-
: RXN-12973show the reaction diagram
generic compounds
-
1-acylglycerophosphocholine O-acyltransferase
dihomo gamma-linolenoyl-CoA + glycerolipid = [glycerolipid]-di-homo-gamma-linolenate + coenzyme A
: arachidonate biosynthesis I (6-desaturase, lower eukaryotes)
: RXN-16044show the reaction diagram
n.a.
-
arachidonate 15-lipoxygenase
di-homo-gamma-linolenate + dioxygen = 15(S)-HpETrE
: di-homo-gamma-linolenate metabolites biosynthesis
: RXN-23442show the reaction diagram
-
-
prostaglandin-endoperoxide synthase
di-homo-gamma-linolenate + dioxygen + reduced two electron carrier = prostaglandin H1 + H2O + oxidized electron carrier
: di-homo-gamma-linolenate metabolites biosynthesis
: RXN-23445show the reaction diagram
generic compounds
-
di-homo-gamma-linolenate + dioxygen = prostaglandin G1
-
: RXN-23446show the reaction diagram
-
-
phospholipase A2
[glycerolipid]-di-homo-gamma-linolenate + H2O = di-homo-gamma-linolenate + glycerolipid + H+
: di-homo-gamma-linolenate metabolites biosynthesis
: RXN-23521show the reaction diagram
n.a.
-
linoleate 8R-lipoxygenase
dihomo-gamma-linolenate + O2 = (8Z,11Z,14Z)-8-hydroxyeicosa-8,11,14-trienoic acid
-
: BS445450show the reaction diagram
incomplete
-
linoleate 8R-lipoxygenase
dihomo-gamma-linolenic acid + O2 = 8-hydroxydihomo-gamma-linolenic acid
-
: BS441310show the reaction diagram
incomplete
-
acyl-lipid (11-3)-desaturase
11,14-eicosadienoic acid + reduced acceptor + O2 = 8,11,14-eicosatrienoic acid + acceptor + H2O
-
: BS375572show the reaction diagram
-
-
diacylglycerol O-acyltransferase
dihomo gamma-linolenoyl-CoA + 1,2-diacyl-sn-glycerol = CoA + 1,2-diacyl-3-dihomo-gamma-linolenoylglycerol
-
: BS455583show the reaction diagram
-
-
arachidonate 12-lipoxygenase
8,11,14-eicosatrienoic acid + O2 = 12-hydroxyeicosatrienoic acid
-
: BS260724show the reaction diagram
incomplete
-
arachidonate 15-lipoxygenase
8,11,14-eicosatrienoic acid + O2 = 15-hydroperoxy-8,11,13-eicosatrienoic acid
-
: BS355927show the reaction diagram
-
-
unspecific peroxygenase
eicosa-8,11,14-trienoic acid + H2O2 = 14,15-epoxyeicosa-8,11-dienoic acid + H2O
-
: BS462467show the reaction diagram
n.a.
-
arachidonate-CoA ligase
ATP + 8,11,14-eicosatrienoate + CoA = AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
-
: BS177show the reaction diagram
-
-
long-chain-fatty-acid-CoA ligase
ATP + dihomo-gamma-linolenate + CoA = AMP + diphosphate + dihomo-gamma-linolenoyl-CoA
: arachidonate biosynthesis
: BS443134show the reaction diagram
incomplete
-
fatty acid amide hydrolase
8,11,14-eicosatrienamide + H2O = 8,11,14-eicosatrienoic acid + NH3
-
: BS399793show the reaction diagram
-
-
arachidonate 12-lipoxygenase
O2 + 8,11,14-Eicosatrienoate <=> (8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-8,10,14-trienoate
-
: 14338
incomplete
-