New release (2023.1) online!
Learn more about features, functions and data:
BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
Please click here for detailed information about the synonyms.
Results per page 
  • 10 results
  • 50 results
  • 100 results
  • 500 results
  • 100000 results
Show or hide columns 
  • EC Number
  • Reaction
  • Pathways
  • Reaction IDs
  • Stoichiometry Check
  • Missing Substrate
  • Missing Product
  • Commentary
  • Remark
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
caffeine synthase
S-adenosyl-L-methionine + 3,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
-
theobromine synthase
S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
-
caffeine synthase
S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
-
caffeine dehydrogenase
caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol
-
-
1,3,7-trimethylxanthine + O2 + NADPH + H+ = 1,3-dimethylxanthine + formaldehyde + NADP+ + H2O
-
: caffeine demethylase
1,3,7-trimethylxanthine + O2 + NADPH + H+ = 1,3-dimethylxanthine + formaldehyde + NADP+ + H2O
-
: caffeine demethylase
7-methylxanthine demethylase
1,3,7-trimethylxanthine + O2 + NADPH + H+ = 1,3-dimethylxanthine + formaldehyde + NADP+ + H2O
-
: caffeine demethylase
7-methylxanthine demethylase
1,3,7-trimethylxanthine + O2 + NADPH + H+ = 1,7-dimethylxanthine + formaldehyde + NADP+ + H2O
-
: CYP1A2
methylxanthine N3-demethylase
1,3,7-trimethylxanthine + O2 + NADPH + H+ = 1,7-dimethylxanthine + formaldehyde + NADP+ + H2O
-
: CYP1A2
unspecific monooxygenase
1,3,7-trimethylxanthine + O2 + NADPH + H+ = 1,7-dimethylxanthine + formaldehyde + NADP+ + H2O
-
: CYP1A2
caffeine + dioxygen + H2O = 1,3,7-trimethylurate + hydrogen peroxide
-
-
caffeine = 1,3,7-trimethylurate
incomplete
: This reaction has not been characterized. The enzymes catalyzing it are not known, and it can not be balanced for the times being |CITS: [12009315][18068204]|.
unspecific monooxygenase
caffeine + reduced [NADPH-hemoprotein reductase] + dioxygen = paraxanthine + oxidized [NADPH-hemoprotein reductase] + formaldehyde + H2O
-
generic compounds
-
caffeine + H+ = caffeine + H+
-
-
-
7-methylxanthine demethylase
caffeine + 2 O2 + 2 NADH + 2 H+ = 7-methylxanthine + 2 NAD+ + 2 H2O + 2 formaldehyde
-
-
-
7-methylxanthine demethylase
caffeine + 3 O2 + 3 NADH + 3 H+ = xanthine + 3 NAD+ + 3 H2O + 3 formaldehyde
-
-
-
caffeine dehydrogenase
caffeine + ubiquinone-0 = trimethyl uric acid + ubiquinol-0
-
incomplete
-
7.6.2.2
ABC-type xenobiotic transporter
ATP + H2O + caffeine/in = ADP + phosphate + caffeine/out
-
-
-