BKMS-react online

New release (2023.1) online!
Learn more about features, functions and data:

BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

Please click here for detailed information about the synonyms.

download this result
as tab stop separated values (Excel, OpenOffice) format

EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Commentary

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BR131

, BR132

, BS369144

: R04562

, R04563

, R04582

, R04604

: 6.3.4.10-RXN

, 6.3.4.9-RXN

: 4235

: two-step reaction (see R01074 + R05145) R05145 and R01074 are general reactions; two-step reaction (see R01074 + R05145) R05145 and R01074 are general reactions; two-step reaction (see R01074 + R05145) R05145 and R01074 are general reactions; two-step reaction (see R01074 + R05145) R05145 and R01074 are general reactions

6.3.4.11

biotin-[methylcrotonoyl-CoA-carboxylase] ligase

ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BR131

, BR132

, BS369144

: R04562

, R04563

, R04582

, R04604

: 6.3.4.10-RXN

, 6.3.4.9-RXN

: 4235

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BR131

, BR132

, BS369144

: R04562

, R04563

, R04582

, R04604

: 6.3.4.10-RXN

, 6.3.4.9-RXN

: 4235

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BR131

, BR132

, BS369144

: R04562

, R04563

, R04582

, R04604

: 6.3.4.10-RXN

, 6.3.4.9-RXN

: 4235

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine

: biotin biosynthesis

: biotin-carboxyl carrier protein assembly

: BR136

: BIOTINLIG-RXN

3.5.1.12

biotinidase

biotin amide + H2O = biotin + NH3

: BR19234

: R01076

: BIOTINIDASE-RXN

6.2.1.11

biotin-CoA ligase

ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA

: BR62

: R01075

: BIOTIN--COA-LIGASE-RXN

: two-step reaction (see R01074+R03762)

3.5.1.12

biotinidase

epsilon-N-biotinyl-L-lysine + H2O = biotin + L-lysine

: Biotin metabolism,
Metabolic pathways

: BS116041

: R01077

: RXN-16474

biotin + ATP = biotinyl-5'-AMP + diphosphate

: Biotin metabolism,
Metabolic pathways

: BS398826

: R01074

: RXN0-7192

: first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) subsequently R05145 or R03762

6.2.1.11

biotin-CoA ligase

biotin + ATP = biotinyl-5'-AMP + diphosphate

: Biotin metabolism,
Metabolic pathways

: BS398826

: R01074

: RXN0-7192

: first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) subsequently R05145 or R03762

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

biotin + ATP = biotinyl-5'-AMP + diphosphate

: Biotin metabolism,
Metabolic pathways

: BS398826

: R01074

: RXN0-7192

: first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) subsequently R05145 or R03762

6.3.4.11

biotin-[methylcrotonoyl-CoA-carboxylase] ligase

biotin + ATP = biotinyl-5'-AMP + diphosphate

: Biotin metabolism,
Metabolic pathways

: BS398826

: R01074

: RXN0-7192

: first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) subsequently R05145 or R03762

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

biotin + ATP = biotinyl-5'-AMP + diphosphate

: Biotin metabolism,
Metabolic pathways

: BS398826

: R01074

: RXN0-7192

: first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) subsequently R05145 or R03762

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

biotin + ATP = biotinyl-5'-AMP + diphosphate

: Biotin metabolism,
Metabolic pathways

: BS398826

: R01074

: RXN0-7192

: first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) subsequently R05145 or R03762

2.8.1.6

biotin synthase

dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin

: BR48103

: 13730

generic compounds

3.5.1.12

biotinidase

biotinyl-6-aminoquinoline + H2O = biotin + 6-aminoquinoline

: BS116051

: 12508

2.8.1.6

biotin synthase

Dethiobiotin + Sulfur donor + 2 S-Adenosyl-L-methionine + 2 e- + 2 H+ <=> Biotin + 2 L-Methionine + 2 5'-Deoxyadenosine

: Biotin metabolism,
Metabolic pathways,
Biosynthesis of cofactors

: R01078

generic compounds

: the reactant sulfur is not elemental sulfur, but it may be from the enzyme itself ([2Fe-2S] iron-sulfur centre) multi-step reaction

1.-.-.-

Biotin sulfoxide + NADPH + H+ <=> Biotin + NADP+ + H2O

: Biotin metabolism,
Metabolic pathways

: R10127

: biotin d-sulfoxide reductase

2.8.1.6

biotin synthase

S-adenosyl-L-methionine + sulfurated [sulfur carrier] + dethiobiotin + reduced [2Fe-2S] ferredoxin = unsulfurated [sulfur carrier] + biotin + 5'-deoxyadenosine + L-methionine + oxidized [2Fe-2S] ferredoxin

: 2.8.1.6-RXN

generic compounds

6.3.4.11

biotin-[methylcrotonoyl-CoA-carboxylase] ligase

[3-methylcrotonoyl-CoA-carboxylase]-L-lysine + biotin + ATP = [methylcrotonoyl-CoA carboxylase]-biotin-N6-L-lysine + diphosphate + AMP + H+

: 6.3.4.11-RXN

n.a.

S-adenosyl-L-methionine + 4,5-secobiotin = biotin + 5'-deoxyadenosine + L-methionine + H+

: biotin biosynthesis from 8-amino-7-oxononanoate II,
biotin biosynthesis from 8-amino-7-oxononanoate I,
biotin biosynthesis from 8-amino-7-oxononanoate III

: RXN-17473

1.8.4.-

d-biotin d-sulfoxide + reduced thioredoxin = biotin + oxidized thioredoxin + H2O

: RXN0-6277

generic compounds

biotin = biotin

: TRANS-RXN0-240

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ITP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS373506

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

ITP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = IMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

: BS743

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ITP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] = IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS669

generic compounds

2.3.2.13

protein-glutamine gamma-glutamyltransferase

[T26 protein]-L-glutamine + 5-(biotinamido)-pentylamine = [T26 protein]-N5-pentyl-L-glutamine + biotin

: BS436196

n.a.

3.5.1.12

biotinidase

N-(+)biotinyl-4-aminobenzoic acid + H2O = 4-aminobenzoic acid + biotin

: BS397834

3.5.1.12

biotinidase

N-biotinyl-3-aminobenzoic acid + H2O = biotin + 3-aminobenzoic acid

: BS116053

2.8.1.6

biotin synthase

dethiobiotin + Na2S = biotin

: BS388522

incomplete

3.5.1.12

biotinidase

biotinyl-di-iodotyramine + H2O = biotin + di-iodotyramine

: BS116063

3.5.1.12

biotinidase

biotinyl-monoiodotyramine + H2O = biotin + monoiodotyramine

: BS116062

3.5.1.12

biotinidase

p-(N-biotinylamino)benzoic acid + H2O = biotin + p-aminobenzoic acid

: BS116042

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

GTP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS373347

6.3.4.14

biotin carboxylase

GTP + D-biotin + HCO3- = GDP + phosphate + carboxybiotin

: BS679

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

GTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = GMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

: BS742

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

GTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] = GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS668

generic compounds

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

CTP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS372780

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

CTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = CMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

: BS741

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

CTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] = CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS667

generic compounds

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

UTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = UMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

: BS744

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

UTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] = UMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS666

generic compounds

3.5.1.12

biotinidase

2-(N-biotinyl)-amino-5-nitro-benzoic acid + H2O = biotin + 2-amino-5-nitrobenzoic acid

: BS116043

3.5.1.12

biotinidase

3-(N-biotinyl)-amino-6-nitrobenzoic acid + H2O = biotin + 3-amino-6-nitrobenzoic acid

: BS116044

2.8.1.6

biotin synthase

dethiobiotin + sulfur = biotin

: BS360047

2.8.1.6

biotin synthase

9-mercaptodethiobiotin + sulfur = biotin

: BS360048

incomplete

3.5.1.12

biotinidase

N-biotinyl-beta-alanine + H2O = biotin + beta-alanine

: BS116048

3.5.1.12

biotinidase

biotinyl-4-aminobenzoic acid + H2O = biotin + 4-aminobenzoic acid

: BS116050

6.3.3.3

dethiobiotin synthase

ATP + diaminobiotin + CO2 = ADP + phosphate + biotin

: BS655

incomplete

6.3.4.14

biotin carboxylase

ATP + biotin + HCO3- = ADP + phosphate + carboxybiotin

: BS372448

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + fluorescein-labeled peptide 85-11 = ADP + diphosphate + biotinyl-fluorescein-labeled peptide 85-11

: BS400088

generic compounds

2.8.1.6

biotin synthase

dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine

: biotin biosynthesis

: BS398860

2.8.1.6

biotin synthase

9-mercaptodethiobiotin + [S] + S-adenosyl-L-methionine = biotin + L-methionine + 5'-deoxyadenosine

: BS425851

incomplete

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + GLNDIFEAQKIEWH = AMP + diphosphate + biotinylated GLNDIFEAQKIEWH

: BS416608

incomplete

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[acetyl-CoA carboxylase 1] = AMP + diphosphate + acetyl-CoA carboxylase 1

: BS407122

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[acetyl-CoA carboxylase 2] = AMP + diphosphate + acetyl-CoA carboxylase 2

: BS407123

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + CGGGSGGGSGLNDIFEAQKIEWH = AMP + diphosphate + biotinylated CGGGSGGGSGLNDIFEAQKIEWH

: BS443123

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[acetyl CoA carboxylase] = AMP + diphosphate + acetyl CoA carboxylase

: BS416605

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[acetyl-CoA carboxylase] = AMP + diphosphate + acetyl-CoA carboxylase

: BS407121

generic compounds

6.3.4.9

biotin-[methylmalonyl-CoA-carboxytransferase] ligase

ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

: BS740

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]

: BS665

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

avitagged BirA + biotin + ATP = BirA-avitag-biotin + AMP + diphosphate

: BS380561

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apocarboxylase = AMP + diphosphate + holocarboxylase

: BS407126

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apocarboxylase = AMP + diphosphate + holocarboxylase

: BS407126

n.a.

6.3.4.11

biotin-[methylcrotonoyl-CoA-carboxylase] ligase

ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]

: BS670

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apoacetyl-CoA carboxylase = AMP + diphosphate + holoacetyl-CoA carboxylase

: BS372444

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apo-beta-methylcrotonyl-CoA carboxylase = AMP + diphosphate + holo-beta-methylcrotonyl-CoA carboxylase

: BS372442

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apopyruvate carboxylase = AMP + diphosphate + holopyruvate carboxylase

: BS372447

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apopropionyl-CoA carboxylase = AMP + diphosphate + holopropionyl-CoA carboxylase

: BS372446

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

avitag-tagged maltose-binding protein + biotin + ATP = maltose-binding protein-avitag-biotin + AMP + diphosphate

: BS380560

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + protein p67 = AMP + diphosphate + biotinyl-protein p67

: BS400089

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apo-[propionyl CoA carboxylase] = AMP + diphosphate + propionyl CoA carboxylase

: BS407124

generic compounds

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + apo-[propionyl-CoA carboxylase] = AMP + diphosphate + propionyl-CoA carboxylase

: BS407125

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[propionyl-CoA carboxylase] = AMP + diphosphate + propionyl-CoA carboxylase

: BS407125

generic compounds

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + histone H4 = AMP + diphosphate + biotin-histone H4

: BS407127

generic compounds

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + BCCP87 = AMP + diphosphate + biotin-BCCP87

: BS408473

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + histone H2A = AMP + diphosphate + biotin-histone H2A

: BS408474

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + protein Syn67 = AMP + diphosphate + protein Syn67-biotin

: BS408475

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + histone H3.2 = AMP + diphosphate + biotin-histone H3.2

: BS416610

n.a.

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + histone H3.2 N-terminal amino acids 1-25 = AMP + diphosphate + biotin-histone H3.2 N-terminal amino acids 1-25

: BS416609

generic compounds

6.3.4.10

biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

ATP + biotin + p67 = AMP + diphosphate + biotinyl-p67

: BS416611

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + C-terminal domain of apo-biotin carboxyl carrier protein = AMP + diphosphate + biotinylated C-terminal domain of acetyl CoA carboxylase

: BS416606

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + C-terminal domain of apo-biotin carboxyl carrier protein = AMP + diphosphate + biotinylated C-terminal domain of apo-biotin carboxyl carrier protein

: BS416607

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + [Escherichia coli apo-biotin-carboxyl-carrier-protein mutant M136S]-L-lysine = AMP + diphosphate + [Escherichia coli biotin-carboxyl-carrier-protein mutant M136S]-biotinyl-L-lysine

: BS425950

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + [Escherichia coli apo-biotin-carboxyl-carrier-protein]-L-lysine = AMP + diphosphate + [Escherichia coli biotin-carboxyl-carrier-protein]-biotinyl-L-lysine

: BS425951

generic compounds

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + [Sulfolobus tokodaii apo-biotin-carboxyl-carrier-protein mutant S136M]-lysine = AMP + diphosphate + [Sulfolobus tokodaii biotin-carboxyl-carrier-protein mutant S136M]-biotinyllysine

: BS425952

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + [Sulfolobus tokodaii apo-biotin-carboxyl-carrier-protein]-lysine = AMP + diphosphate + [Sulfolobus tokodaii biotin-carboxyl-carrier-protein]-biotinyllysine

: BS425953

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + apo-[biotin carboxyl carrier protein] = AMP + diphosphate + biotinylated biotin carboxyl carrier protein

: BS428232

n.a.

6.3.4.15

biotin-[biotin carboxyl-carrier protein] ligase

ATP + biotin + AccB-86 = AMP + diphosphate + biotinylated AccB-86

: BS443120

generic compounds