testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
3beta(or 20alpha)-hydroxysteroid dehydrogenase
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
3alpha-hydroxysteroid 3-dehydrogenase
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
3(or 17)beta-hydroxysteroid dehydrogenase
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
17beta-estradiol 17-dehydrogenase
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
testosterone 17beta-dehydrogenase (NADP+)
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
-
: NADP+ (see R01838)
11beta-hydroxysteroid dehydrogenase
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
estradiol 17alpha-dehydrogenase
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
carbonyl reductase (NADPH)
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
alcohol dehydrogenase (NADP+)
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
3(or 17)alpha-hydroxysteroid dehydrogenase
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
3(or 17)beta-hydroxysteroid dehydrogenase
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
17beta-estradiol 17-dehydrogenase
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
testosterone 17beta-dehydrogenase (NADP+)
testosterone + NADP+ = androstenedione + NADPH + H+
-
: NAD+ (see R01836)
C-19 steroid 1alpha-hydroxylase
testosterone + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 1alpha-hydroxytestosterone + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
generic compounds
-
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
testosterone + NADPH + H+ = 5alpha-dihydrotestosterone + NADP+
-
-
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
testosterone + NADPH + H+ = 5alpha-dihydrotestosterone + NADP+
-
-
3-oxosteroid 1-dehydrogenase
testosterone + acceptor = 17beta-hydroxyandrost-1,4-diene-3-one + reduced acceptor
-
-
3'-phosphoadenylylsulfate + testosterone = adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
3'-phosphoadenylylsulfate + testosterone = adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
3'-phosphoadenylylsulfate + testosterone = adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
3'-phosphoadenylylsulfate + testosterone = adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
steroid 11beta-monooxygenase
testosterone + reduced adrenal ferredoxin + O2 = 11beta-hydroxytestosterone + oxidized adrenal ferredoxin + H2O
-
-
testosterone + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = 17beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
-
-
: three-step reaction (see R02501+R04761+R03087)
testosterone + O2 + [reduced NADPH-hemoprotein reductase] = 19-hydroxytestosterone + H2O + [oxidized NADPH-hemoprotein reductase]
-
: aromatase, ARO three successive reactions (R02501+R04761+R03087) subsequently R04761
DELTA4-3-oxosteroid 5beta-reductase
testosterone + NADPH + H+ = (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
-
-
UDP-D-glucuronate + testosterone = UDP + testosterone 17-O-beta-D-glucuronoside
-
-
androstendiol + NAD+ = testosterone + NADH + H+
-
: NADPH (see R02500)
3beta-hydroxy-DELTA5-steroid dehydrogenase
androstendiol + NAD+ = testosterone + NADH + H+
-
: NADPH (see R02500)
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
testosterone + NADPH + H+ = 4-androsten-3alpha,17beta-diol + NADP+
-
-
-
3(or 17)alpha-hydroxysteroid dehydrogenase
testosterone + NADPH + H+ = 4-androsten-3alpha,17beta-diol + NADP+
-
-
-
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
testosterone + NADPH + H+ = 4-androsten-3alpha,17beta-diol + NADP+
-
-
-
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
testosterone + NADPH + H+ = 4-androsten-3alpha,17beta-diol + NADP+
-
-
-
3beta-hydroxy-DELTA5-steroid dehydrogenase
testosterone + NADPH + H+ = 3beta,17beta-dihydroxy-4-androsten + NADP+
-
-
-
carbonyl reductase (NADPH)
testosterone + NADPH + H+ = 3beta,17beta-dihydroxy-4-androsten + NADP+
-
-
-
testosterone + NADPH + O2 = 6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
cholesterol 24-hydroxylase
testosterone + NADPH + O2 = 6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
testosterone + NADPH + O2 = 6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
taurochenodeoxycholate 6alpha-hydroxylase
testosterone + NADPH + O2 = 6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
progesterone monooxygenase
testosterone + NADPH + O2 = 6beta-hydroxytestosterone + NADP+ + H2O
-
-
-
Testosterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 7alpha-Hydroxytestosterone + [Oxidized NADPH---hemoprotein reductase] + H2O
generic compounds
-
testosterone + reduced [NADPH-hemoprotein reductase] + dioxygen = 17beta-estradiol + oxidized [NADPH-hemoprotein reductase] + H2O + formate + H+
-
generic compounds
-
17beta-hydroxyandrost-5-en-3-one = testosterone
-
-
testosterone + reduced [NADPH-hemoprotein reductase] + dioxygen = 19-hydroxytestosterone + oxidized [NADPH-hemoprotein reductase] + H2O
generic compounds
-
testosterone + reduced [NADPH-hemoprotein reductase] + dioxygen = 6-beta-hydroxytestosterone + oxidized [NADPH-hemoprotein reductase] + H2O
-
generic compounds
-
testosterone + 3 O2 + 3 reduced flavoproteins = 17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins
-
generic compounds
-
3-ketosteroid 9alpha-monooxygenase
4-androstene-17beta-ol-3-one + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha,17beta-dihydroxy-4-androstene-3-one + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
generic compounds
-
testosterone + [reduced NADPH-hemoprotein reductase] + O2 = 6beta-hydroxytestosterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
testosterone + H2O2 = 17beta-hydroxy-4,5-epoxy-5beta-androstan-3-one + 16alpha,17beta-dihydroxyandrost-4-en-3-one + H2O
-
incomplete
-
3-oxosteroid 1-dehydrogenase
4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol = 1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
-
-
-
testosterone + UDPglucuronate = UDP + testosterone O-glucuronide
-
-
-
androst-4-ene-3,17-dione monooxygenase
androst-4-ene-3,17-dione + AH2 + O2 = 17beta-hydroxyandrost-4-en-3-one + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta,17beta-dihydroxyandrost-4-en-3-one + 11alpha,17beta-dihydroxyandrost-4-en-3-one + 15alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O
-
-
-
androst-4-ene-3,17-dione monooxygenase
androst-4-ene-3,17-dione + AH2 + O2 = 17beta-hydroxyandrost-4-en-3-one + 11beta-hydroxyandrost-4-ene-3,17-dione + 17alpha-oxa-D-homo-androst-4-ene-3,17-dione + A + H2O
-
-
-
steroid 11beta-monooxygenase
testosterone + reduced adrenodoxin + O2 = 11-hydroxytestosterone + oxidized adrenodoxin + H2O
-
generic compounds
-
steroid 15beta-monooxygenase
testosterone + reduced adrenodoxin + O2 = 15beta-hydroxytestosterone + oxidized adrenodoxin + H2O
-
generic compounds
-
steroid 15beta-monooxygenase
testosterone + reduced acceptor + O2 = 15beta-hydroxytestosterone + oxidized acceptor + H2O
-
generic compounds
-
steroid 15beta-monooxygenase
testosterone + reduced megaredoxin + O2 = 15beta-hydroxytestosterone + oxidized megaredoxin + H2O
-
generic compounds
-
testosterone 17-sulfate + H2O = testosterone + sulfate
-
-
-
testosterone 17-sulfate + H2O = testosterone + sulfate
-
-
-
progesterone 11alpha-monooxygenase
testosterone + AH2 + O2 = 11alpha-hydroxytestosterone + A + H2O
-
-
-
3-oxo-5beta-steroid 4-dehydrogenase
testosterone + NADH = 17beta-hydroxy-5beta-androstan-3-one + NAD+
-
-
-
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
testosterone + NADH + H+ = 4-androsten-3alpha,17beta-diol + NAD+
-
-
-
3(or 17)beta-hydroxysteroid dehydrogenase
17beta-hydroxy-5beta-androstane-3-one + NADH + H+ = testosterone + NAD+
-
-
-
3(or 17)beta-hydroxysteroid dehydrogenase
androstenediol + NADH + H+ = testosterone + NAD+
-
-
-
3beta-hydroxy-DELTA5-steroid dehydrogenase
4-androsten-3beta,17beta-diol + NAD+ = 4-androsten-17beta-ol-3-one + NADH
-
-
-
3beta-hydroxy-DELTA5-steroid dehydrogenase
DELTA5-androstenediol + NAD+ = testosterone + NADH + H+
-
n.a.
-
3alpha-hydroxysteroid 3-dehydrogenase
testosterone + NADH + H+ = DELTA4-androstene-3,17-dione + NAD+
-
-
-
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
testosterone + NADPH + H+ = androstan-3alpha,17beta-diol + androstan-3beta,17beta-diol + 5alpha-dihydrotestosterone
-
incomplete
-
3(or 17)alpha-hydroxysteroid dehydrogenase
epitestosterone + NADP+ = testosterone + NADPH + H+
-
-
-
testosterone + NADP+ = androst-4-ene-3,17-dione + NADH + H+
-
incomplete
-
17beta-estradiol 17-dehydrogenase
testosterone + NADP+ = androst-4-ene-3,17-dione + NADH + H+
-
incomplete
-
3(or 17)beta-hydroxysteroid dehydrogenase
17beta-hydroxy-5beta-androstane-3-one + NADPH + H+ = testosterone + NADP+
-
-
-
3(or 17)beta-hydroxysteroid dehydrogenase
androstenediol + NADPH + H+ = testosterone + NADP+
-
-
-
3alpha-hydroxysteroid 3-dehydrogenase
testosterone + NADPH + H+ = DELTA4-androstene-3,17-dione + NADP+
-
-
-
sterol 3beta-glucosyltransferase
UDP-glucose + testosterone = UDP + testosterone-17-yl beta-D-glucopyranoside
-
-
-
sterol 27-beta-glucosyltransferase
UDP-glucose + testosterone = UDP + testosterone-17-yl beta-D-glucopyranoside
-
-
-
progesterone monooxygenase
testosterone + reduced acceptor + O2 = 15alpha-hydroxytestosterone + 15beta-hydroxytestosterone + 2beta-hydroxytestosterone + acceptor + H2O
-
-
-
3-oxo-5beta-steroid 4-dehydrogenase
17beta-hydroxy-5beta-androstan-3-one + menaphthone = testosterone + reduced acceptor
-
-
-
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
testosterone + reduced acceptor = 5alpha-dihydrotestosterone + acceptor
-
-
-
testosterone oleate + H2O = testosterone + oleate
-
-
-
Testosterone + O2 + H+ + NADPH <=> NADP+ + H2O + 15beta-Hydroxytestosterone
-
incomplete
-
Testosterone + O2 + H+ + NADPH <=> H2O + 1beta-Hydroxytestosterone + NADP+
-
incomplete
-
NADPH + Testosterone + O2 + H+ <=> NADP+ + H2O + 2beta-Hydroxytestosterone
-
incomplete
-
O2 + Testosterone + H+ + NADPH <=> NADP+ + H2O + Formate + Estradiol-17beta
-
incomplete
-
cholesterol 24-hydroxylase
Testosterone + NADPH + H+ + O2 <=> H2O + 16beta-Hydroxytestosterone + NADP+
-
incomplete
-
cholesterol 24-hydroxylase
NADPH + H+ + O2 + Testosterone <=> NADP+ + 2-Hydroxytestosterone + H2O
-
incomplete
-
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