BKMS-react online

Pathways

vitamin B1 metabolism (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

3.5.99.2

aminopyrimidine aminohydrolase

thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast)

: BR49840

: R02133

: THIAMINASE-RXN

natural substrates

2.7.1.50

hydroxyethylthiazole kinase

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
thiamine formation from pyrithiamine and oxythiamine (yeast),
thiamine salvage II

: BR47785

: R04448

: THIAZOLSYN3-RXN

natural substrates

2.2.1.7

1-deoxy-D-xylulose-5-phosphate synthase

pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2

: vitamin B1 metabolism,
isoprenoid biosynthesis

: Thiamine metabolism,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: pyridoxal 5'-phosphate biosynthesis I,
methylerythritol phosphate pathway I,
methylerythritol phosphate pathway II,
thiazole biosynthesis I (facultative anaerobic bacteria),
thiazole biosynthesis II (aerobic bacteria)

: BR37092

, BS260856

: R05636

: DXS-RXN

natural substrates

2.7.1.49

hydroxymethylpyrimidine kinase

ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis,
thiamine salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine formation from pyrithiamine and oxythiamine (yeast),
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis

: BR48075

: R04509

: PYRIMSYN3-RXN

natural substrates

2.7.4.7

phosphooxymethylpyrimidine kinase

ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: BR48075

: R04509

: PYRIMSYN3-RXN

natural substrates

4.1.99.17

phosphomethylpyrimidine synthase

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis

: BR49773

: R03472

: PYRIMSYN1-RXN

natural substrates

2.7.1.35

pyridoxal kinase

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine formation from pyrithiamine and oxythiamine (yeast)

: BR47783

: R03471

: OHMETPYRKIN-RXN

: 3265

natural substrates

2.7.1.49

hydroxymethylpyrimidine kinase

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine formation from pyrithiamine and oxythiamine (yeast)

: BR47783

: R03471

: OHMETPYRKIN-RXN

: 3265

natural substrates

2.7.4.7

phosphooxymethylpyrimidine kinase

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
hydroxymethylpyrimidine salvage,
thiamine formation from pyrithiamine and oxythiamine (yeast)

: BR47783

: R03471

: OHMETPYRKIN-RXN

: 3265

natural substrates

2.5.1.3

thiamine phosphate synthase

4-amino-2-methyl-5-(diphosphomethyl)pyrimidine + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = diphosphate + thiamine phosphate + CO2

: vitamin B1 metabolism

: thiamine diphosphate biosynthesis I (E. coli)

: BR47665

: R11312

: RXN-12611

: Studies with the enzyme from Bacillus subtilis suggested that the preferred substrate for the enzyme in vivo is CPD-13576 [21534620]. However, the enzyme also accepts |FRAME:THZ-P| with similar efficiency.

natural substrates

2.7.1.21

thymidine kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine salvage II,
thiamine salvage I,
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate biosynthesis II (Bacillus)

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.12

T2-induced deoxynucleotide kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.13

(deoxy)nucleoside-phosphate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.16

thiamine-phosphate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.3

adenylate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.4

nucleoside-phosphate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.8

guanylate kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.4.9

dTMP kinase

ATP + thiamine phosphate = ADP + thiamine diphosphate

: pyrimidine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways,
Pyrimidine metabolism

: BR47844

, BR48076

: R00617

, R02094

: DTMPKI-RXN

, THI-P-KIN-RXN

: 1007, 14622

natural substrates

2.7.6.2

thiamine diphosphokinase

ATP + thiamine = AMP + thiamine diphosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine diphosphate biosynthesis III (Staphylococcus),
thiamine salvage III

: BR47855

: R00619

: THIAMIN-PYROPHOSPHOKINASE-RXN

natural substrates

2.3.1.61

dihydrolipoyllysine-residue succinyltransferase

succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine

: vitamin B1 metabolism

: Citrate cycle (TCA cycle)

: BR44062

: R02570

: 2-oxoglutarate dehydrogenase complex:dihydrolipoyllysine-residue succinyltransferase a part of multi-step reaction (see R08549, R01700+R02570+R07618) following after R01700

natural substrates, protein

3.1.3.1

alkaline phosphatase

thiamine phosphate + H2O = thiamine + phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine diphosphate biosynthesis III (Staphylococcus)

: BR51620

: R02135

: RXNQT-4191

natural substrates

3.1.3.100

thiamine phosphate phosphatase

thiamine phosphate + H2O = thiamine + phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine diphosphate biosynthesis III (Staphylococcus)

: BR51620

: R02135

: RXNQT-4191

natural substrates

3.1.3.2

acid phosphatase

thiamine phosphate + H2O = thiamine + phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine diphosphate biosynthesis III (Staphylococcus)

: BR51620

: R02135

: RXNQT-4191

natural substrates

2.4.2.60

cysteine-dependent adenosine diphosphate thiazole synthase

NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O

: vitamin B1 metabolism

: BR52385

n.a.

natural substrates

2.8.1.7

cysteine desulfurase

L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine

: alanine metabolism,
vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: BR49765

: R07460

: [Enzyme] is the enzyme itself [KO:K04487].

natural substrates

2.8.1.7

cysteine desulfurase

[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor

: vitamin B1 metabolism

: BR49766

natural substrates, generic

2.7.7.73

sulfur carrier protein ThiS adenylyltransferase

ATP + [ThiS] = diphosphate + adenylyl-[ThiS]

: vitamin B1 metabolism

: thiazole biosynthesis I (facultative anaerobic bacteria),
thiazole biosynthesis II (aerobic bacteria)

: BR49425

: RXN-9789

natural substrates, protein

4.1.99.19

2-iminoacetate synthase

L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+

: vitamin B1 metabolism

: thiazole biosynthesis I (facultative anaerobic bacteria)

: BR49775

: RXN-11319

natural substrates

2.8.1.10

thiazole synthase

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O

: vitamin B1 metabolism

: BS416005

natural substrates, protein

2.5.1.3

thiamine phosphate synthase

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)thiazole = diphosphate + thiamine phosphate

: vitamin B1 metabolism

: Thiamine metabolism,
Metabolic pathways

: thiamine salvage IV (yeast),
thiamine formation from pyrithiamine and oxythiamine (yeast),
thiamine diphosphate biosynthesis IV (eukaryotes),
thiamine salvage II

: BR51526

: R03223

: THI-P-SYN-RXN

: 3049

natural substrates