Pathways

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BRENDA KEGG MetaCyc

ubiquinone biosynthesis (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
all-trans-octaprenyl-diphosphate synthase
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate
BR49324 show the reaction diagram
R09248 show the reaction diagram
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: 5-step reaction see R02061+R07475+R05613+R05612+R05611
natural substrates
all-trans-decaprenyl-diphosphate synthase
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate
BR49324 show the reaction diagram
R09248 show the reaction diagram
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: 5-step reaction see R02061+R07475+R05613+R05612+R05611
natural substrates
3-demethylubiquinol 3-O-methyltransferase
S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8
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natural substrates
2-octaprenyl-6-methoxyphenol hydroxylase
2-methoxy-6-(all-trans-octaprenyl)phenol + a reduced electron acceptor + oxygen = 6-all-trans-octaprenyl-2-methoxy-1,4-benzoquinol + a reduced electron acceptor + H2O
BR51542 show the reaction diagram
generic compounds
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natural substrates, generic
2-polyprenyl-6-hydroxyphenol methylase
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
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: ubiG
: The enzyme is involved in the pathway of ubiquinone-8 in Escherichia coli. COQ3 from human, yeast and rat also catalyse the reaction although this is not a step in biosynthesis of ubiquinone in these organisms [10419476]. The enzyme also catalyses the methylation of 3-demethylubiquinone-8 (this activity is classified as EC 2.1.1.64) [8703953].
natural substrates
3-demethoxyubiquinol 3-hydroxylase
6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen = an oxidized electron acceptor + 3-demethylubiquinol-8 + H2O
generic compounds
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natural substrates, generic
4-hydroxybenzoate polyprenyltransferase
octaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-octaprenylbenzoate + diphosphate
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: UbiA
natural substrates
4-hydroxy-3-polyprenylbenzoate decarboxylase
3-octaprenyl-4-hydroxybenzoate = 2-octaprenylphenol + CO2
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natural substrates
0.0.0.0
spontaneous reaction
ubiquinol-8 = H+ + ubiquinone
BR52881 show the reaction diagram
incomplete
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C35H57
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natural substrates