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Pathways

ubiquinone biosynthesis (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

2.5.1.90

all-trans-octaprenyl-diphosphate synthase

(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate

: ubiquinone biosynthesis

: Terpenoid backbone biosynthesis,
Biosynthesis of secondary metabolites

: octaprenyl diphosphate biosynthesis

: BR49324

: R09248

: RXN-8992

: 5-step reaction see R02061+R07475+R05613+R05612+R05611

natural substrates

2.5.1.91

all-trans-decaprenyl-diphosphate synthase

(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate

: ubiquinone biosynthesis

: Terpenoid backbone biosynthesis,
Biosynthesis of secondary metabolites

: octaprenyl diphosphate biosynthesis

: BR49324

: R09248

: RXN-8992

: 5-step reaction see R02061+R07475+R05613+R05612+R05611

natural substrates

4.1.3.40

chorismate lyase

chorismate = 4-hydroxybenzoate + pyruvate

: ubiquinone biosynthesis

: Ubiquinone and other terpenoid-quinone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: polybrominated dihydroxylated diphenyl ethers biosynthesis,
spongiadioxin C biosynthesis,
polybrominated phenols biosynthesis,
phenolphthiocerol biosynthesis,
p-HBAD biosynthesis,
tetrahydromethanopterin biosynthesis,
ubiquinol-8 biosynthesis (eukaryotic),
4-hydroxybenzoate biosynthesis II (bacteria)

: BR48792

: R01302

: CHORPYRLY-RXN

: UbiC

natural substrates

2.1.1.64

3-demethylubiquinol 3-O-methyltransferase

S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8

: ubiquinone biosynthesis

: ubiquinol-8 biosynthesis (prokaryotic),
ubiquinol-8 biosynthesis (eukaryotic)

: BS407327

: DHHB-METHYLTRANSFER-RXN

natural substrates

1.14.99.B5

2-octaprenyl-6-methoxyphenol hydroxylase

2-methoxy-6-(all-trans-octaprenyl)phenol + a reduced electron acceptor + oxygen = 6-all-trans-octaprenyl-2-methoxy-1,4-benzoquinol + a reduced electron acceptor + H2O

: ubiquinone biosynthesis

: BR51542

generic compounds

natural substrates, generic

2.1.1.222

2-polyprenyl-6-hydroxyphenol methylase

S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol

: ubiquinone biosynthesis

: Ubiquinone and other terpenoid-quinone biosynthesis,
Biosynthesis of secondary metabolites

: ubiquinol-8 biosynthesis (prokaryotic)

: BS407324

: R04988

: 2-OCTAPRENYL-6-OHPHENOL-METHY-RXN

: ubiG

: The enzyme is involved in the pathway of ubiquinone-8 in Escherichia coli. COQ3 from human, yeast and rat also catalyse the reaction although this is not a step in biosynthesis of ubiquinone in these organisms [10419476]. The enzyme also catalyses the methylation of 3-demethylubiquinone-8 (this activity is classified as EC 2.1.1.64) [8703953].

natural substrates

1.14.99.60

3-demethoxyubiquinol 3-hydroxylase

6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen = an oxidized electron acceptor + 3-demethylubiquinol-8 + H2O

: ubiquinone biosynthesis

: BS427325

generic compounds

natural substrates, generic

2.5.1.39

4-hydroxybenzoate polyprenyltransferase

octaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-octaprenylbenzoate + diphosphate

: ubiquinone biosynthesis

: Ubiquinone and other terpenoid-quinone biosynthesis,
Biosynthesis of secondary metabolites

: ubiquinol-8 biosynthesis (prokaryotic),
ubiquinol-8 biosynthesis (eukaryotic)

: BS409991

: R05615