Print
mycocyclosin synthase
Pathways
tyrosine metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
; "show the reaction diagram")
generic compounds
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natural substrates, generic, protein
cyclo(L-tyrosyl-L-tyrosyl) synthase
2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)
; "show the reaction diagram")
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natural substrates, nucleotide
tyrosine-tRNA ligase
ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr
; "show the reaction diagram")
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natural substrates
tyrosine decarboxylase
L-tyrosine = tyramine + CO2
; "show the reaction diagram")
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natural substrates
aromatic-L-amino-acid decarboxylase
L-tyrosine = tyramine + CO2
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natural substrates
tyrosine phenol-lyase
L-tyrosine + H2O = phenol + pyruvate + NH3
; "show the reaction diagram")
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natural substrates
branched-chain-2-oxoacid decarboxylase
4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2
; "show the reaction diagram")
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natural substrates
indolepyruvate decarboxylase
4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2
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natural substrates
4-hydroxyphenylpyruvate decarboxylase
4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2
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natural substrates
alanine-oxo-acid transaminase
L-tyrosine + pyruvate = 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
; "show the reaction diagram")
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natural substrates
alanine-glyoxylate transaminase
L-tyrosine + pyruvate = 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
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natural substrates
tyrosine transaminase
L-tyrosine + pyruvate = 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
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natural substrates
serine-pyruvate transaminase
L-tyrosine + pyruvate = 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
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natural substrates
phenylalanine(histidine) transaminase
L-tyrosine + pyruvate = 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
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natural substrates
prephenate dehydrogenase
prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+
; "show the reaction diagram")
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natural substrates
prephenate dehydrogenase (NADP+)
prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+
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natural substrates
arogenate dehydrogenase [NAD(P)+]
prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+
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natural substrates
aspartate transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
; "show the reaction diagram")
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natural substrates
alanine transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
diiodotyrosine transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
tryptophan transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
2-aminoadipate transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
branched-chain-amino-acid transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
dihydroxyphenylalanine transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
tyrosine transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
aromatic-amino-acid transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
kynurenine-oxoglutarate transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
glutamate-prephenate aminotransferase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
histidinol-phosphate transaminase
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
: Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,
Phenylalanine, tyrosine and tryptophan biosynthesis,
Novobiocin biosynthesis,
Isoquinoline alkaloid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: (S)-reticuline biosynthesis I,4-hydroxybenzoate biosynthesis I (eukaryotes),
rosmarinic acid biosynthesis I,
L-tyrosine degradation V (Stickland reaction),
L-tyrosine biosynthesis I,
atromentin biosynthesis,
L-tyrosine degradation IV (to 4-methylphenol),
L-tyrosine degradation III,
4-hydroxyphenylpyruvate biosynthesis,
L-tyrosine degradation I,
L-tyrosine degradation II
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natural substrates
aspartate transaminase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
; "show the reaction diagram")
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natural substrates
aromatic-amino-acid transaminase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
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natural substrates
aspartate-prephenate aminotransferase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
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natural substrates
glutamate-prephenate aminotransferase
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
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natural substrates
arogenate dehydrogenase
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 + H+
; "show the reaction diagram")
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: NAD+ (ec 1.3.1.79, see R00732)natural substrates
arogenate dehydrogenase (NADP+)
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 + H+
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: NAD+ (ec 1.3.1.79, see R00732)natural substrates
arogenate dehydrogenase [NAD(P)+]
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 + H+
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: NAD+ (ec 1.3.1.79, see R00732)natural substrates
4-hydroxyphenylpyruvate dioxygenase
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2
; "show the reaction diagram")
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: multi-step reactionnatural substrates, multi-step reaction
homogentisate 1,2-dioxygenase
homogentisate + O2 = 4-maleylacetoacetate
; "show the reaction diagram")
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natural substrates
maleylacetoacetate isomerase
4-Maleylacetoacetate = 4-fumarylacetoacetate
; "show the reaction diagram")
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natural substrates
fumarylacetoacetase
4-fumarylacetoacetate + H2O = acetoacetate + fumarate
; "show the reaction diagram")
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natural substrates
4-hydroxyphenylpyruvate oxidase
2 4-hydroxyphenylpyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2
; "show the reaction diagram")
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natural substrates