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BRENDA KEGG MetaCyc

lysine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
D-amino-acid oxidase
D-Lys + H2O + O2 = 6-amino-2-oxohexanoic acid + NH3 + H2O2
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: This deaminating oxidation reaction is incompletely characterized [17259313].
natural substrates
3-keto-5-aminohexanoate cleavage enzyme
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
BR51399 show the reaction diagram
R10564 show the reaction diagram
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natural substrates
L-erythro-3,5-diaminohexanoate dehydrogenase
L-erythro-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxohexanoate + NH3 + NADH + H+
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natural substrates
lysine 5,6-aminomutase
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate
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natural substrates
D-lysine 5,6-aminomutase
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate
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natural substrates
4-hydroxy-tetrahydrodipicolinate reductase
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+
BR36807 show the reaction diagram
R04199 show the reaction diagram
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: NAD+ (see R04198)
: Studies of the enzyme from the bacterium TAX-562 have shown that the enzyme accepts CPD-14443 and not 2-3-DIHYDRODIPICOLINATE as originally thought [20503968].
natural substrates
lysine 2,3-aminomutase
L-lysine = (3S)-3,6-diaminohexanoate
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: radical intermediate
natural substrates
4-aminobutyrate-2-oxoglutarate transaminase
L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate
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natural substrates
L-lysine 6-transaminase
L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate
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natural substrates
5-aminopentanamidase
5-aminopentanamide + H2O = 5-aminopentanoate + NH3
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natural substrates
alanine racemase
L-lysine = D-lysine
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natural substrates
amino-acid racemase
L-lysine = D-lysine
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natural substrates
lysine racemase
L-lysine = D-lysine
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natural substrates
arginine racemase
L-lysine = D-lysine
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natural substrates
L-aminoadipate-semialdehyde dehydrogenase
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NAD+ + 2 H2O <=> L-2-Aminoadipate + NADH + H+
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: second step of two-step reaction (see R03102, R02317+R11231)
natural substrates
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NAD+ + 2 H2O <=> L-2-Aminoadipate + NADH + H+
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: second step of two-step reaction (see R03102, R02317+R11231)
natural substrates
L-pipecolate oxidase
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
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natural substrates
0.0.0.0
spontaneous reaction
2-oxo-6-amino-hexanoate + D-lysine = DELTA1-piperidine 2-carboxylate
BR52892 show the reaction diagram
incomplete
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C6O3N2H16
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natural substrates
2-oxo-6-amino-hexanoate + hydrogen peroxide = 5-aminopentanoate + H2O + CO2
BR52891 show the reaction diagram
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natural substrates
0.0.0.0
spontaneous reaction
2-oxo-6-amino-hexanoate + hydrogen peroxide = 5-aminopentanoate + H2O + CO2
BR52891 show the reaction diagram
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natural substrates
saccharopine dehydrogenase (NAD+, L-glutamate-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
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natural substrates
saccharopine dehydrogenase (NADP+, L-lysine-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
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natural substrates
lysine 2-monooxygenase
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O
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natural substrates
glutarate-semialdehyde dehydrogenase
5-oxopentanoate + NAD+ + H2O = glutarate + NADH + H+
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natural substrates
L-glutamate gamma-semialdehyde dehydrogenase
5-oxopentanoate + NAD+ + H2O = glutarate + NADH + H+
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natural substrates
4-aminobutyrate-2-oxoglutarate transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
BR47695 show the reaction diagram
R02274 show the reaction diagram
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natural substrates
alanine transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
BR47695 show the reaction diagram
R02274 show the reaction diagram
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natural substrates
5-aminovalerate transaminase
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
BR47695 show the reaction diagram
R02274 show the reaction diagram
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natural substrates
5-acetamidopentanoate + H2O = acetate + 5-aminopentanoate
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natural substrates
4-acetamidobutyrate deacetylase
5-acetamidopentanoate + H2O = acetate + 5-aminopentanoate
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natural substrates
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
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natural substrates
L-lysine 6-transaminase
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
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natural substrates
N6-acetyl-beta-lysine transaminase
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
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natural substrates
2-aminohexanoate transaminase
6-N-acetyl-L-lysine + 2-oxoglutarate = 6-(N-acetylamino)-2-oxohexanoate + L-glutamate
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natural substrates
acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine
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natural substrates
lysine N-acetyltransferase
acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine
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natural substrates
L-aminoadipate-semialdehyde dehydrogenase
(S)-2-amino-6-oxohexanoate + NADP+ + H2O = L-2-aminoadipate + NADPH + H+
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: NAD+ (see R03102) two-step reaction (see R02317+R11232)
natural substrates
saccharopine dehydrogenase (NADP+, L-glutamate-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+
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natural substrates
saccharopine dehydrogenase (NAD+, L-lysine-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
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natural substrates
saccharopine dehydrogenase (NADP+, L-lysine-forming)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
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natural substrates
SPONTANEOUS
L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O
BR52889 show the reaction diagram
R04336 show the reaction diagram
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: non-enzymatic
natural substrates
0.0.0.0
spontaneous reaction
L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O
BR52889 show the reaction diagram
R04336 show the reaction diagram
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: non-enzymatic
natural substrates
L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O
BR52889 show the reaction diagram
R04336 show the reaction diagram
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: non-enzymatic
natural substrates
diaminopimelate dehydrogenase
meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+
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natural substrates
succinyldiaminopimelate transaminase
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate
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natural substrates
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate
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natural substrates
4-hydroxy-tetrahydrodipicolinate reductase
2,3-dihydrodipicolinate + NADH = 2,3,4,5-tetrahydrodipicolinate + NAD+
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natural substrates
4-hydroxy-tetrahydrodipicolinate synthase
L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O
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succinyl-diaminopimelate desuccinylase
N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate
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natural substrates
LL-diaminopimelate aminotransferase
LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O
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natural substrates
N-acetyldiaminopimelate deacetylase
N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate
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natural substrates
2,3,4,5-Tetrahydrodipicolinate + Acetyl-CoA + H2O <=> N-Acetyl-L-2-amino-6-oxopimelate + CoA
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natural substrates
tetrahydrodipicolinate N-acetyltransferase
2,3,4,5-Tetrahydrodipicolinate + Acetyl-CoA + H2O <=> N-Acetyl-L-2-amino-6-oxopimelate + CoA
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natural substrates
isocitrate-homoisocitrate dehydrogenase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
BR48021 show the reaction diagram
R01934 show the reaction diagram
1988
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: two-step reaction (see R04862+R01936), reversible
natural substrates
isocitrate dehydrogenase (NADP+)
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
BR48021 show the reaction diagram
R01934 show the reaction diagram
1988
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: two-step reaction (see R04862+R01936), reversible
natural substrates
homoisocitrate dehydrogenase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
BR48021 show the reaction diagram
R01934 show the reaction diagram
1988
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: two-step reaction (see R04862+R01936), reversible
natural substrates
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
BR49014 show the reaction diagram, BS1972 show the reaction diagram
R03444 show the reaction diagram
3238
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: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
methanogen homoaconitase
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
BR49014 show the reaction diagram, BS1972 show the reaction diagram
R03444 show the reaction diagram
3238
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: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
homoaconitate hydratase
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
BR49014 show the reaction diagram, BS1972 show the reaction diagram
R03444 show the reaction diagram
3238
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: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
BR49014 show the reaction diagram, BS1972 show the reaction diagram
R03444 show the reaction diagram
3238
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: first step of two-step reaction (see R09720, R03444+R04371)
natural substrates
methanogen homoaconitase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
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: second step of two-step reaction (see R09720, R03444+R04371)
: Requires a CPD-7 for activity. In contrast to EC 4.2.1.36, ENZRXN-7008, this enzyme can catalyze both the dehydration of HOMO-CIT to form HOMO-CIS-ACONITATE and the subsequent hydration reaction that forms HOMO-I-CIT. In addition to HOMO-CIS-ACONITATE, the enzyme can also catalyze the hydration of the physiological substrates CPD-152 and CPD-301 as well as the non-physiological substrate CPD-10749. CIS-ACONITATE, THREO-DS-ISO-CITRATE and CPD-10745 cannot act as substrates, and CPD-150 and CPD-149 act as inhibitors of the enzyme [18765671].
natural substrates
homoaconitate hydratase
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
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: second step of two-step reaction (see R09720, R03444+R04371)
: Requires a CPD-7 for activity. In contrast to EC 4.2.1.36, ENZRXN-7008, this enzyme can catalyze both the dehydration of HOMO-CIT to form HOMO-CIS-ACONITATE and the subsequent hydration reaction that forms HOMO-I-CIT. In addition to HOMO-CIS-ACONITATE, the enzyme can also catalyze the hydration of the physiological substrates CPD-152 and CPD-301 as well as the non-physiological substrate CPD-10749. CIS-ACONITATE, THREO-DS-ISO-CITRATE and CPD-10745 cannot act as substrates, and CPD-150 and CPD-149 act as inhibitors of the enzyme [18765671].
natural substrates
lysine-tRNA ligase
ATP + L-lysine + tRNALys = AMP + diphosphate + L-lysyl-tRNALys
BR57 show the reaction diagram
R03658 show the reaction diagram
414
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natural substrates
[amino group carrier protein]-L-2-aminoadipate ligase
ATP + an [amino group carrier protein]-C-terminal-L-glutamate + L-2-aminoadipate = ADP + phosphate + an [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine
generic compounds
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C6O3N1H9
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natural substrates, protein
[amino group carrier protein]-6-phospho-L-2-aminoadipate reductase
an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP+ = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H+
BR52965 show the reaction diagram
generic compounds
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natural substrates
[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase
an [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
BR52999 show the reaction diagram
generic compounds
N1H3
O1
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natural substrates, protein
2.6.1.ah
an [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
BR52999 show the reaction diagram
generic compounds
N1H3
O1
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natural substrates, protein
[amino group carrier protein]-lysine hydrolase
[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-lysine
BR52699 show the reaction diagram
n.a.
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natural substrates, protein