Print
2'-dehydrokanamycin reductase
Pathways
kanamycin biosynthesis (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+
; "show the reaction diagram")
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natural substrates
kanamycin B dioxygenase
kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
; "show the reaction diagram")
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natural substrates
2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B
; "show the reaction diagram")
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natural substrates
2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
UDP-alpha-D-kanosamine + paromamine = UDP + kanamycin C
; "show the reaction diagram")
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natural substrates
neomycin C transaminase
neomycin C + 2-oxoglutarate = 6'''-deamino-6'''-oxoneomycin C + L-glutamate
; "show the reaction diagram")
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natural substrates
6'''-hydroxyneomycin C oxidase
6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2
; "show the reaction diagram")
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natural substrates
2'''-acetyl-6'''-hydroxyneomycin C deacetylase
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate
; "show the reaction diagram")
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natural substrates
UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
UDP-N-acetyl-alpha-D-glucosamine + ribostamycin = UDP + 2'''-acetyl-6'''-hydroxyneomycin C
; "show the reaction diagram")
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natural substrates
2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine = UDP + kanamycin A
; "show the reaction diagram")
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natural substrates
2'-deamino-2'-hydroxyneamine transaminase
2'-deamino-2'-hydroxyparomamine + L-glutamate = 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate
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2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine = UDP + kanamycin X
; "show the reaction diagram")
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natural substrates
2-deoxystreptamine glucosyltransferase
UDP-alpha-D-glucose + 2-deoxystreptamine = UDP + 2'-deamino-2'-hydroxyparomamine
; "show the reaction diagram")
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natural substrates
2'-N-acetylparomamine deacetylase
2'-N-acetylparomamine + H2O = paromamine + acetate
; "show the reaction diagram")
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natural substrates
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine = UDP + 2'-N-acetylparomamine
; "show the reaction diagram")
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natural substrates
L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxystreptamine
; "show the reaction diagram")
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natural substrates
glutamine-scyllo-inositol transaminase
L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxystreptamine
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natural substrates
2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine
; "show the reaction diagram")
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: radical SAM 2-deoxy-scyllo-inosamine dehydrogenasenatural substrates
2-deoxy-scyllo-inosamine dehydrogenase
2-deoxy-scyllo-inosamine + NADP+ = 3-amino-2,3-dideoxy-scyllo-inosose + NADPH + H+
; "show the reaction diagram")
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natural substrates
L-glutamine:2-deoxy-scyllo-inosose aminotransferase
L-glutamine + 2-deoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
; "show the reaction diagram")
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natural substrates
glutamine-scyllo-inositol transaminase
L-glutamine + 2-deoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
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natural substrates
glucose-1-phosphate thymidylyltransferase
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose
: Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,
Acarbose and validamycin biosynthesis,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of nucleotide sugars
: dTDP-sibirosamine biosynthesis,dTDP-beta-L-rhamnose biosynthesis,
dTDP-N-acetylviosamine biosynthesis,
dTDP-beta-D-fucofuranose biosynthesis,
dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis,
dTDP-beta-L-digitoxose biosynthesis,
dTDP-4-O-demethyl-beta-L-noviose biosynthesis,
dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis,
dTDP-L-daunosamine biosynthesis,
dTDP-6-deoxy-alpha-D-allose biosynthesis,
dTDP-D-desosamine biosynthesis,
dTDP-alpha-D-mycaminose biosynthesis,
dTDP-beta-L-mycarose biosynthesis,
dTDP-beta-L-olivose biosynthesis,
dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis,
dTDP-alpha-D-forosamine biosynthesis,
dTDP-beta-L-megosamine biosynthesis,
dTDP-beta-L-4-epi-vancosamine biosynthesis,
dTDP-N-acetylthomosamine biosynthesis,
dTDP-3-acetamido-alpha-D-fucose biosynthesis
; "show the reaction diagram")
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natural substrates
UTP-monosaccharide-1-phosphate uridylyltransferase
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose
: Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,
Acarbose and validamycin biosynthesis,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of nucleotide sugars
: dTDP-sibirosamine biosynthesis,dTDP-beta-L-rhamnose biosynthesis,
dTDP-N-acetylviosamine biosynthesis,
dTDP-beta-D-fucofuranose biosynthesis,
dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis,
dTDP-beta-L-digitoxose biosynthesis,
dTDP-4-O-demethyl-beta-L-noviose biosynthesis,
dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis,
dTDP-L-daunosamine biosynthesis,
dTDP-6-deoxy-alpha-D-allose biosynthesis,
dTDP-D-desosamine biosynthesis,
dTDP-alpha-D-mycaminose biosynthesis,
dTDP-beta-L-mycarose biosynthesis,
dTDP-beta-L-olivose biosynthesis,
dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis,
dTDP-alpha-D-forosamine biosynthesis,
dTDP-beta-L-megosamine biosynthesis,
dTDP-beta-L-4-epi-vancosamine biosynthesis,
dTDP-N-acetylthomosamine biosynthesis,
dTDP-3-acetamido-alpha-D-fucose biosynthesis
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natural substrates
UTP-glucose-1-phosphate uridylyltransferase
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose
: Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,
Acarbose and validamycin biosynthesis,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of nucleotide sugars
: dTDP-sibirosamine biosynthesis,dTDP-beta-L-rhamnose biosynthesis,
dTDP-N-acetylviosamine biosynthesis,
dTDP-beta-D-fucofuranose biosynthesis,
dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis,
dTDP-beta-L-digitoxose biosynthesis,
dTDP-4-O-demethyl-beta-L-noviose biosynthesis,
dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis,
dTDP-L-daunosamine biosynthesis,
dTDP-6-deoxy-alpha-D-allose biosynthesis,
dTDP-D-desosamine biosynthesis,
dTDP-alpha-D-mycaminose biosynthesis,
dTDP-beta-L-mycarose biosynthesis,
dTDP-beta-L-olivose biosynthesis,
dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis,
dTDP-alpha-D-forosamine biosynthesis,
dTDP-beta-L-megosamine biosynthesis,
dTDP-beta-L-4-epi-vancosamine biosynthesis,
dTDP-N-acetylthomosamine biosynthesis,
dTDP-3-acetamido-alpha-D-fucose biosynthesis
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natural substrates
paromamine 6'-oxidase
paromamine + O2 = 6'-dehydroparomamine + H2O2
; "show the reaction diagram")
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natural substrates
neamine transaminase
neamine + 2-oxoglutarate = 6'-dehydroparomamine + L-glutamate
; "show the reaction diagram")
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natural substrates
neamine phosphoribosyltransferase
neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
; "show the reaction diagram")
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natural substrates
5''-phosphoribostamycin phosphatase
5''-phosphoribostamycin + H2O = ribostamycin + phosphate
; "show the reaction diagram")
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natural substrates
ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + ribostamycin = gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein
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natural substrates, generic, protein
gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
gamma-L-glutamyl-butirosin B = butirosin B + 5-oxo-L-proline
; "show the reaction diagram")
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natural substrates