BKMS-react online

Pathways

isoleucine metabolism (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

download this result
as tab stop separated values (Excel, OpenOffice) format

EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

3-methyloxaloacetate = 2-oxobutanoate + CO2

: isoleucine metabolism

: C5-Branched dibasic acid metabolism

: L-isoleucine biosynthesis III

: BS390752

: R00995

: RXN-7746

natural substrates

4.1.1.112

oxaloacetate decarboxylase

3-methyloxaloacetate = 2-oxobutanoate + CO2

: isoleucine metabolism

: C5-Branched dibasic acid metabolism

: L-isoleucine biosynthesis III

: BS390752

: R00995

: RXN-7746

natural substrates

5.4.99.1

methylaspartate mutase

L-threo-3-methylaspartate = L-glutamate

: isoleucine metabolism,
glutamate and glutamine metabolism

: Glyoxylate and dicarboxylate metabolism,
C5-Branched dibasic acid metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

: methylaspartate cycle,
L-glutamate degradation VI (to pyruvate),
L-isoleucine biosynthesis III

: BR33

, BS427238

: R00262

: METHYLASPARTATE-MUTASE-RXN

: 767

natural substrates

2.3.3.13

2-isopropylmalate synthase

acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate

: isoleucine metabolism

: Valine, leucine and isoleucine biosynthesis,
C5-Branched dibasic acid metabolism,
Metabolic pathways,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

: L-isoleucine biosynthesis II

: BR48833

: R07399

: RXN-7743

: 9043

natural substrates

2.3.1.182

(R)-citramalate synthase

acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate

: isoleucine metabolism

: Valine, leucine and isoleucine biosynthesis,
C5-Branched dibasic acid metabolism,
Metabolic pathways,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

: L-isoleucine biosynthesis II

: BR48833

: R07399

: RXN-7743

: 9043

natural substrates

4.2.1.31

maleate hydratase

(R)-2-Methylmalate = 2-methylmaleate + H2O

: isoleucine metabolism

: Valine, leucine and isoleucine biosynthesis,
C5-Branched dibasic acid metabolism,
Metabolic pathways,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

: 2,5-xylenol and 3,5-xylenol degradation,
L-isoleucine biosynthesis II

: BR415

: R03896

: R-2-METHYLMALATE-DEHYDRATASE-RXN

: 3641

natural substrates

4.2.1.35

(R)-2-methylmalate dehydratase

(R)-2-Methylmalate = 2-methylmaleate + H2O

: isoleucine metabolism

: Valine, leucine and isoleucine biosynthesis,
C5-Branched dibasic acid metabolism,
Metabolic pathways,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

: 2,5-xylenol and 3,5-xylenol degradation,
L-isoleucine biosynthesis II

: BR415

: R03896

: R-2-METHYLMALATE-DEHYDRATASE-RXN

: 3641

natural substrates

2.6.1.42

branched-chain-amino-acid transaminase

L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate

: isoleucine metabolism

: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

: L-isoleucine biosynthesis V,
L-isoleucine biosynthesis I (from threonine),
L-isoleucine degradation I,
L-isoleucine biosynthesis II,
L-isoleucine biosynthesis IV,
L-isoleucine biosynthesis III,
L-isoleucine degradation II

: BS356522

: R02199

: BRANCHED-CHAINAMINOTRANSFERILEU-RXN

: 2171, 9086

: Also acts on L-leucine and L-valine.

natural substrates

2.6.1.67

2-aminohexanoate transaminase

L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate

: isoleucine metabolism

: BS356522

: R02199

: BRANCHED-CHAINAMINOTRANSFERILEU-RXN

: 2171, 9086

: Also acts on L-leucine and L-valine.

natural substrates

2.2.1.6

acetolactate synthase

pyruvate + 2-oxobutyrate = 2-aceto-2-hydroxybutyrate + CO2

: isoleucine metabolism

: BS432921

natural substrates

1.1.1.86

ketol-acid reductoisomerase (NADP+)

2-aceto-2-hydroxybutyrate + NADPH = 2,3-dihydroxy-3-methylvalerate + NADP+

: isoleucine metabolism

: BS383015

natural substrates

4.2.1.9

dihydroxy-acid dehydratase

2,3-dihydroxy-3-methylpentanoate = 3-methyl-2-oxopentanoate + H2O

: isoleucine metabolism

: BS18755

1.2.7.1

pyruvate synthase

2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin

: isoleucine metabolism,
threonine metabolism

: Propanoate metabolism,
Metabolic pathways

: 2-oxobutanoate degradation II,
L-isoleucine biosynthesis IV

: BS189350

: R01199

: 2-OXOBUTYRATE-SYNTHASE-RXN

natural substrates, generic, protein

1.2.7.11

2-oxoacid oxidoreductase (ferredoxin)

2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin

: isoleucine metabolism,
threonine metabolism

: Propanoate metabolism,
Metabolic pathways

: 2-oxobutanoate degradation II,
L-isoleucine biosynthesis IV

: BS189350

: R01199

: 2-OXOBUTYRATE-SYNTHASE-RXN

natural substrates, generic, protein

1.2.7.7

3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin

: isoleucine metabolism,
threonine metabolism

: Propanoate metabolism,
Metabolic pathways

: 2-oxobutanoate degradation II,
L-isoleucine biosynthesis IV

: BS189350

: R01199

: 2-OXOBUTYRATE-SYNTHASE-RXN

natural substrates, generic, protein

6.2.1.1

acetate-CoA ligase

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

: propanol degradation,
alanine metabolism,
isoleucine metabolism

: Metabolic pathways

: 2-methylcitrate cycle II,
L-isoleucine biosynthesis IV,
2-methylcitrate cycle I,
beta-alanine biosynthesis II

: BR68

: R00925

: PROPIONATE--COA-LIGASE-RXN

: 1245

: two-step reaction (see R01354+R00926)

natural substrates

6.2.1.17

propionate-CoA ligase

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

: propanol degradation,
alanine metabolism,
isoleucine metabolism

: Metabolic pathways

: 2-methylcitrate cycle II,
L-isoleucine biosynthesis IV,
2-methylcitrate cycle I,
beta-alanine biosynthesis II

: BR68

: R00925

: PROPIONATE--COA-LIGASE-RXN

: 1245

: two-step reaction (see R01354+R00926)

natural substrates

6.2.1.2

medium-chain acyl-CoA ligase

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

: propanol degradation,
alanine metabolism,
isoleucine metabolism

: Metabolic pathways

: 2-methylcitrate cycle II,
L-isoleucine biosynthesis IV,
2-methylcitrate cycle I,
beta-alanine biosynthesis II

: BR68

: R00925

: PROPIONATE--COA-LIGASE-RXN

: 1245

: two-step reaction (see R01354+R00926)

natural substrates

6.2.1.30

phenylacetate-CoA ligase

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

: propanol degradation,
alanine metabolism,
isoleucine metabolism

: Metabolic pathways

: 2-methylcitrate cycle II,
L-isoleucine biosynthesis IV,
2-methylcitrate cycle I,
beta-alanine biosynthesis II

: BR68

: R00925

: PROPIONATE--COA-LIGASE-RXN

: 1245

: two-step reaction (see R01354+R00926)

natural substrates

6.2.1.36

3-hydroxypropionyl-CoA synthase

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

: propanol degradation,
alanine metabolism,
isoleucine metabolism

: Metabolic pathways

: 2-methylcitrate cycle II,
L-isoleucine biosynthesis IV,
2-methylcitrate cycle I,
beta-alanine biosynthesis II

: BR68

: R00925

: PROPIONATE--COA-LIGASE-RXN

: 1245

: two-step reaction (see R01354+R00926)

natural substrates

6.2.1.44

3-(methylthio)propionyl-CoA ligase

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA

: propanol degradation,
alanine metabolism,
isoleucine metabolism

: Metabolic pathways

: 2-methylcitrate cycle II,
L-isoleucine biosynthesis IV,
2-methylcitrate cycle I,
beta-alanine biosynthesis II

: BR68

: R00925

: PROPIONATE--COA-LIGASE-RXN

: 1245

: two-step reaction (see R01354+R00926)

natural substrates

6.1.1.5

isoleucine-tRNA ligase

ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle

: isoleucine metabolism

: Aminoacyl-tRNA biosynthesis

: BR56

: R03656

: 413

natural substrates

6.1.1.9

valine-tRNA ligase

ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle

: isoleucine metabolism

: Aminoacyl-tRNA biosynthesis

: BR56

: R03656

: 413

natural substrates