Pathways
isoleucine metabolism (BRENDA)






EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
3-methyloxaloacetate = 2-oxobutanoate + CO2
-
-
-
-
natural substrates
oxaloacetate decarboxylase
3-methyloxaloacetate = 2-oxobutanoate + CO2
-
-
-
-
natural substrates
methylaspartate mutase
L-threo-3-methylaspartate = L-glutamate
-
-
-
-
natural substrates
2-isopropylmalate synthase
acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate
-
-
-
-
natural substrates
(R)-citramalate synthase
acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate
-
-
-
-
natural substrates
maleate hydratase
(R)-2-Methylmalate = 2-methylmaleate + H2O
-
-
-
-
natural substrates
(R)-2-methylmalate dehydratase
(R)-2-Methylmalate = 2-methylmaleate + H2O
-
-
-
-
natural substrates
branched-chain-amino-acid transaminase
L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate
-
-
-

natural substrates
2-aminohexanoate transaminase
L-isoleucine + 2-oxoglutarate = 3-methyl-2-oxopentanoate + L-glutamate
-
-
-

natural substrates
acetolactate synthase
pyruvate + 2-oxobutyrate = 2-aceto-2-hydroxybutyrate + CO2
-
-
-
-
natural substrates
ketol-acid reductoisomerase (NADP+)
2-aceto-2-hydroxybutyrate + NADPH = 2,3-dihydroxy-3-methylvalerate + NADP+
-
-
-
-
natural substrates
dihydroxy-acid dehydratase
2,3-dihydroxy-3-methylpentanoate = 3-methyl-2-oxopentanoate + H2O
-
-
-
-
-
pyruvate synthase
2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin
-
-
-
-
natural substrates, generic, protein
2-oxoacid oxidoreductase (ferredoxin)
2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin
-
-
-
-
natural substrates, generic, protein
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
2-oxobutyrate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin
-
-
-
-
natural substrates, generic, protein
acetate-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
-
-
-

natural substrates
propionate-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
-
-
-

natural substrates
medium-chain acyl-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
-
-
-

natural substrates
phenylacetate-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
-
-
-

natural substrates
3-hydroxypropionyl-CoA synthase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
-
-
-

natural substrates
3-(methylthio)propionyl-CoA ligase
ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA
-
-
-

natural substrates
isoleucine-tRNA ligase
ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle
-
-
-
-
natural substrates
valine-tRNA ligase
ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle
-
-
-
-
natural substrates