Pathways

Filter results:
BRENDA KEGG MetaCyc

citric acid cycle (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
malate dehydrogenase [NAD(P)+]
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
: citric acid cycle,
photosynthesis,
C4 and CAM-carbon fixation
: Pyruvate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: C4 photosynthetic carbon assimilation cycle, PEPCK type,
C4 photosynthetic carbon assimilation cycle, NADP-ME type
: BR29342 show the reaction diagram, BS188648 show the reaction diagram
: R00343 show the reaction diagram
: MALATE-DEHYDROGENASE-NADP+-RXN show the reaction diagram, RXN-10813 show the reaction diagram
: 143
-
-
-
-
natural substrates
malate dehydrogenase
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
: citric acid cycle,
photosynthesis,
C4 and CAM-carbon fixation
: Pyruvate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: C4 photosynthetic carbon assimilation cycle, PEPCK type,
C4 photosynthetic carbon assimilation cycle, NADP-ME type
: BR29342 show the reaction diagram, BS188648 show the reaction diagram
: R00343 show the reaction diagram
: MALATE-DEHYDROGENASE-NADP+-RXN show the reaction diagram, RXN-10813 show the reaction diagram
: 143
-
-
-
-
natural substrates
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
: citric acid cycle,
photosynthesis,
C4 and CAM-carbon fixation
: Pyruvate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: C4 photosynthetic carbon assimilation cycle, PEPCK type,
C4 photosynthetic carbon assimilation cycle, NADP-ME type
: BR29342 show the reaction diagram, BS188648 show the reaction diagram
: R00343 show the reaction diagram
: MALATE-DEHYDROGENASE-NADP+-RXN show the reaction diagram, RXN-10813 show the reaction diagram
: 143
-
-
-
-
natural substrates
glyoxylate reductase (NADP+)
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
: citric acid cycle,
photosynthesis,
C4 and CAM-carbon fixation
: Pyruvate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: C4 photosynthetic carbon assimilation cycle, PEPCK type,
C4 photosynthetic carbon assimilation cycle, NADP-ME type
: BR29342 show the reaction diagram, BS188648 show the reaction diagram
: R00343 show the reaction diagram
: MALATE-DEHYDROGENASE-NADP+-RXN show the reaction diagram, RXN-10813 show the reaction diagram
: 143
-
-
-
-
natural substrates
hydroxypyruvate reductase
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
: citric acid cycle,
photosynthesis,
C4 and CAM-carbon fixation
: Pyruvate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: C4 photosynthetic carbon assimilation cycle, PEPCK type,
C4 photosynthetic carbon assimilation cycle, NADP-ME type
: BR29342 show the reaction diagram, BS188648 show the reaction diagram
: R00343 show the reaction diagram
: MALATE-DEHYDROGENASE-NADP+-RXN show the reaction diagram, RXN-10813 show the reaction diagram
: 143
-
-
-
-
natural substrates
malate dehydrogenase (NADP+)
(S)-malate + NADP+ = oxaloacetate + NADPH + H+
: citric acid cycle,
photosynthesis,
C4 and CAM-carbon fixation
: Pyruvate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: C4 photosynthetic carbon assimilation cycle, PEPCK type,
C4 photosynthetic carbon assimilation cycle, NADP-ME type
: BR29342 show the reaction diagram, BS188648 show the reaction diagram
: R00343 show the reaction diagram
: MALATE-DEHYDROGENASE-NADP+-RXN show the reaction diagram, RXN-10813 show the reaction diagram
: 143
-
-
-
-
natural substrates
L-lactate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
D-lactate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
malate dehydrogenase [NAD(P)+]
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
L-2-hydroxycarboxylate dehydrogenase (NAD+)
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
malate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
malate dehydrogenase (oxaloacetate-decarboxylating)
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
hydroxypyruvate reductase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
malate dehydrogenase (NADP+)
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
3-isopropylmalate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
phosphoglycerate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
diiodophenylpyruvate reductase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: alanine metabolism,
citric acid cycle,
C4 and CAM-carbon fixation
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
: BR29300 show the reaction diagram, BS188027 show the reaction diagram
: R00342 show the reaction diagram
: MALATE-DEH-RXN show the reaction diagram, RXN-10813_WOP show the reaction diagram
: 113
-
-
-
-
natural substrates
acetate-CoA ligase (ADP-forming)
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
partial TCA cycle (obligate autotrophs),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate V
: BR88 show the reaction diagram
: R00405 show the reaction diagram
: SUCCCOASYN-RXN show the reaction diagram
: 260
-
-
-
-
natural substrates
succinate-CoA ligase (GDP-forming)
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
partial TCA cycle (obligate autotrophs),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate V
: BR88 show the reaction diagram
: R00405 show the reaction diagram
: SUCCCOASYN-RXN show the reaction diagram
: 260
-
-
-
-
natural substrates
succinate-CoA ligase (ADP-forming)
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
partial TCA cycle (obligate autotrophs),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate V
: BR88 show the reaction diagram
: R00405 show the reaction diagram
: SUCCCOASYN-RXN show the reaction diagram
: 260
-
-
-
-
natural substrates
succinate dehydrogenase
succinate + a quinone = fumarate + a quinol
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: BR49374 show the reaction diagram
: R02164 show the reaction diagram
-
-
-
: electron transport complex II
natural substrates, multi-step reaction
fumarate reductase (quinol)
succinate + a quinone = fumarate + a quinol
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: BR49374 show the reaction diagram
: R02164 show the reaction diagram
-
-
-
: electron transport complex II
natural substrates, multi-step reaction
fumarate hydratase
(S)-malate = fumarate + H2O
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR3389 show the reaction diagram
: R01082 show the reaction diagram
: FUMHYDR-RXN show the reaction diagram
: 256
-
-
-
-
natural substrates
(S)-2-methylmalate dehydratase
(S)-malate = fumarate + H2O
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR3389 show the reaction diagram
: R01082 show the reaction diagram
: FUMHYDR-RXN show the reaction diagram
: 256
-
-
-
-
natural substrates
citrate (Si)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR44118 show the reaction diagram
: R00351 show the reaction diagram
: CITSYN-RXN show the reaction diagram, RXN-14905 show the reaction diagram
: 267
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
homocitrate synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR44118 show the reaction diagram
: R00351 show the reaction diagram
: CITSYN-RXN show the reaction diagram, RXN-14905 show the reaction diagram
: 267
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
citrate synthase (unknown stereospecificity)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR44118 show the reaction diagram
: R00351 show the reaction diagram
: CITSYN-RXN show the reaction diagram, RXN-14905 show the reaction diagram
: 267
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
citrate (Re)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR44118 show the reaction diagram
: R00351 show the reaction diagram
: CITSYN-RXN show the reaction diagram, RXN-14905 show the reaction diagram
: 267
-
-
-
: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
Citrate = cis-aconitate + H2O
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
reductive TCA cycle I,
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR419 show the reaction diagram
: R01325 show the reaction diagram
: ACONITATEDEHYDR-RXN show the reaction diagram
: 268
-
-
-
-
natural substrates
aconitate hydratase
Citrate = cis-aconitate + H2O
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
reductive TCA cycle I,
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR419 show the reaction diagram
: R01325 show the reaction diagram
: ACONITATEDEHYDR-RXN show the reaction diagram
: 268
-
-
-
-
natural substrates
Citrate = cis-aconitate + H2O
: citric acid cycle
: Citrate cycle (TCA cycle),
Glyoxylate and dicarboxylate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism
: TCA cycle III (animals),
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle II,
reductive TCA cycle I,
ethylene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR419 show the reaction diagram
: R01325 show the reaction diagram
: ACONITATEDEHYDR-RXN show the reaction diagram
: 268
-
-
-
-
natural substrates
isocitrate-homoisocitrate dehydrogenase
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
: citric acid cycle
: Glutathione metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle I,
NAD/NADP-NADH/NADPH cytosolic interconversion (yeast),
ethylene biosynthesis V (engineered),
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR29305 show the reaction diagram, BS370920 show the reaction diagram
: R00267 show the reaction diagram
: ISOCITDEH-RXN show the reaction diagram
: 14842, 15247, 269
-
-
-
: two-step reaction (see R01899+R00268)
natural substrates
isocitrate dehydrogenase (NAD+)
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
: citric acid cycle
: Glutathione metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle I,
NAD/NADP-NADH/NADPH cytosolic interconversion (yeast),
ethylene biosynthesis V (engineered),
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR29305 show the reaction diagram, BS370920 show the reaction diagram
: R00267 show the reaction diagram
: ISOCITDEH-RXN show the reaction diagram
: 14842, 15247, 269
-
-
-
: two-step reaction (see R01899+R00268)
natural substrates
isocitrate dehydrogenase (NADP+)
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
: citric acid cycle
: Glutathione metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
methylaspartate cycle,
TCA cycle I (prokaryotic),
partial TCA cycle (obligate autotrophs),
TCA cycle VII (acetate-producers),
TCA cycle IV (2-oxoglutarate decarboxylase),
reductive TCA cycle I,
NAD/NADP-NADH/NADPH cytosolic interconversion (yeast),
ethylene biosynthesis V (engineered),
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
: BR29305 show the reaction diagram, BS370920 show the reaction diagram
: R00267 show the reaction diagram
: ISOCITDEH-RXN show the reaction diagram
: 14842, 15247, 269
-
-
-
: two-step reaction (see R01899+R00268)
natural substrates
citrate CoA-transferase
acetyl-CoA + citrate = acetate + (3S)-citryl-CoA
: citric acid cycle
: BR47921 show the reaction diagram
: R01323 show the reaction diagram
: 2.8.3.10-RXN show the reaction diagram
-
-
-
-
natural substrates
succinate + FAD = fumarate + FADH2
: citric acid cycle
: BS413615 show the reaction diagram
: R00408 show the reaction diagram
: 865
-
-
-
-
natural substrates
succinate dehydrogenase
succinate + FAD = fumarate + FADH2
: citric acid cycle
: BS413615 show the reaction diagram
: R00408 show the reaction diagram
: 865
-
-
-
-
natural substrates
citryl-CoA lyase
(3S)-citryl-CoA = acetyl-CoA + oxaloacetate
: citric acid cycle
: Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: reductive TCA cycle II
: BR3376 show the reaction diagram
: R00354 show the reaction diagram
: RXN-7929 show the reaction diagram
-
-
-
: a part of multi-step reaction (see R00352, R01322+R00354)
natural substrates
succinyl-CoA:acetate CoA-transferase
succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA
: citric acid cycle
: Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Butanoate metabolism,
Metabolic pathways
: ketolysis,
TCA cycle VI (Helicobacter)
: BS360598 show the reaction diagram
: R00410 show the reaction diagram
: RXNI-2 show the reaction diagram
: 867
-
-
-
-
natural substrates
3-oxoacid CoA-transferase
succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA
: citric acid cycle
: Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Butanoate metabolism,
Metabolic pathways
: ketolysis,
TCA cycle VI (Helicobacter)
: BS360598 show the reaction diagram
: R00410 show the reaction diagram
: RXNI-2 show the reaction diagram
: 867
-
-
-
-
natural substrates
malate synthase
acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA
: citric acid cycle
: Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
TCA cycle IV (2-oxoglutarate decarboxylase),
L-arabinose degradation IV,
D-xylose degradation IV,
chitin degradation to ethanol,
glyoxylate cycle,
glycolate and glyoxylate degradation II
: BR47548 show the reaction diagram, BS381320 show the reaction diagram
: R00472 show the reaction diagram
: MALSYN-RXN show the reaction diagram
: 152
-
-
-
-
natural substrates
isocitrate lyase
acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA
: citric acid cycle
: Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
TCA cycle IV (2-oxoglutarate decarboxylase),
L-arabinose degradation IV,
D-xylose degradation IV,
chitin degradation to ethanol,
glyoxylate cycle,
glycolate and glyoxylate degradation II
: BR47548 show the reaction diagram, BS381320 show the reaction diagram
: R00472 show the reaction diagram
: MALSYN-RXN show the reaction diagram
: 152
-
-
-
-
natural substrates
isocitrate lyase
isocitrate = succinate + glyoxylate
: citric acid cycle
: Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
TCA cycle IV (2-oxoglutarate decarboxylase),
glyoxylate cycle
: BR3364 show the reaction diagram, BS380792 show the reaction diagram
: R00479 show the reaction diagram
: ISOCIT-CLEAV-RXN show the reaction diagram
: 14841, 911
-
-
-
-
natural substrates
maleate isomerase
Maleate = fumarate
: citric acid cycle
: Butanoate metabolism,
Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments
: picolinate degradation,
nicotine degradation III (VPP pathway),
nicotine degradation II (pyrrolidine pathway),
nicotinate degradation I,
nicotinate degradation II
: BR208 show the reaction diagram
: R01087 show the reaction diagram
: MALEATE-ISOMERASE-RXN show the reaction diagram
-
-
-
-
natural substrates
2-oxoacid oxidoreductase (ferredoxin)
2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
: citric acid cycle
: Citrate cycle (TCA cycle),
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
TCA cycle VI (Helicobacter)
: BR50765 show the reaction diagram
: R01197 show the reaction diagram
: 2-OXOGLUTARATE-SYNTHASE-RXN show the reaction diagram
-
-
-
-
natural substrates, generic, protein
2-oxoglutarate synthase
2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
: citric acid cycle
: Citrate cycle (TCA cycle),
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
TCA cycle VI (Helicobacter)
: BR50765 show the reaction diagram
: R01197 show the reaction diagram
: 2-OXOGLUTARATE-SYNTHASE-RXN show the reaction diagram
-
-
-
-
natural substrates, generic, protein
propionate CoA-transferase
succinyl-CoA + acetate = acetyl-CoA + succinate
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: anaerobic energy metabolism (invertebrates, mitochondrial),
succinate fermentation to butanoate,
TCA cycle VII (acetate-producers),
acetate formation from acetyl-CoA (succinate)
: BR50544 show the reaction diagram
: R10343 show the reaction diagram
: RXN-8807 show the reaction diagram
: 14383
-
-
-
-
natural substrates
succinyl-CoA:acetate CoA-transferase
succinyl-CoA + acetate = acetyl-CoA + succinate
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: anaerobic energy metabolism (invertebrates, mitochondrial),
succinate fermentation to butanoate,
TCA cycle VII (acetate-producers),
acetate formation from acetyl-CoA (succinate)
: BR50544 show the reaction diagram
: R10343 show the reaction diagram
: RXN-8807 show the reaction diagram
: 14383
-
-
-
-
natural substrates
acetate CoA-transferase
succinyl-CoA + acetate = acetyl-CoA + succinate
: citric acid cycle
: Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: anaerobic energy metabolism (invertebrates, mitochondrial),
succinate fermentation to butanoate,
TCA cycle VII (acetate-producers),
acetate formation from acetyl-CoA (succinate)
: BR50544 show the reaction diagram
: R10343 show the reaction diagram
: RXN-8807 show the reaction diagram
: 14383
-
-
-
-
natural substrates
isocitrate-homoisocitrate dehydrogenase
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+
: citric acid cycle
: Citrate cycle (TCA cycle),
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle II (plants and fungi),
L-glutamine biosynthesis III
: BR29304 show the reaction diagram, BS371189 show the reaction diagram
: R00709 show the reaction diagram
: ISOCITRATE-DEHYDROGENASE-NAD+-RXN show the reaction diagram
: 15068, 270
-
-
-
-
natural substrates
isocitrate dehydrogenase (NAD+)
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+
: citric acid cycle
: Citrate cycle (TCA cycle),
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle II (plants and fungi),
L-glutamine biosynthesis III
: BR29304 show the reaction diagram, BS371189 show the reaction diagram
: R00709 show the reaction diagram
: ISOCITRATE-DEHYDROGENASE-NAD+-RXN show the reaction diagram
: 15068, 270
-
-
-
-
natural substrates
isocitrate dehydrogenase (NADP+)
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+
: citric acid cycle
: Citrate cycle (TCA cycle),
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle II (plants and fungi),
L-glutamine biosynthesis III
: BR29304 show the reaction diagram, BS371189 show the reaction diagram
: R00709 show the reaction diagram
: ISOCITRATE-DEHYDROGENASE-NAD+-RXN show the reaction diagram
: 15068, 270
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-
-
-
natural substrates
homoisocitrate dehydrogenase
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+
: citric acid cycle
: Citrate cycle (TCA cycle),
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle III (animals),
TCA cycle II (plants and fungi),
L-glutamine biosynthesis III
: BR29304 show the reaction diagram, BS371189 show the reaction diagram
: R00709 show the reaction diagram
: ISOCITRATE-DEHYDROGENASE-NAD+-RXN show the reaction diagram
: 15068, 270
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-
-
-
natural substrates
ATP citrate synthase
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: reductive TCA cycle I,
acetyl-CoA biosynthesis III (from citrate)
: BR44130 show the reaction diagram
: R00352 show the reaction diagram
: ATP-CITRATE-PRO-S--LYASE-RXN show the reaction diagram
: 266
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-
-
: multi-step reaction (see R01322+R00354)
natural substrates, multi-step reaction
malate dehydrogenase (quinone)
(S)-malate + a quinone = oxaloacetate + reduced quinone
: citric acid cycle
: Citrate cycle (TCA cycle),
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: BR49054 show the reaction diagram, BS421758 show the reaction diagram
: R00361 show the reaction diagram
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-
-
-
natural substrates
malate dehydrogenase (quinone)
(S)-malate + acceptor = oxaloacetate + reduced acceptor
: citric acid cycle
: BS402298 show the reaction diagram
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-
-
-
natural substrates, generic
succinate-CoA ligase (GDP-forming)
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA
: citric acid cycle
: Citrate cycle (TCA cycle),
Propanoate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Carbon metabolism
: TCA cycle III (animals)
: BR87 show the reaction diagram
: R00432 show the reaction diagram
: SUCCINATE--COA-LIGASE-GDP-FORMING-RXN show the reaction diagram
: 259
-
-
-
-
natural substrates
citrate-CoA ligase
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
: citric acid cycle
: Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: reductive TCA cycle II
: BR69 show the reaction diagram
: R01322 show the reaction diagram
: CITRATE--COA-LIGASE-RXN show the reaction diagram
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-
-
: a part of multi-step reaction (see R00352, R01322+R00354)
natural substrates