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BRENDA KEGG MetaCyc

citric acid cycle (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
succinate dehydrogenase
succinate + a quinone = fumarate + a quinol
BR49374 show the reaction diagram
R02164 show the reaction diagram
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: electron transport complex II
natural substrates, multi-step reaction
fumarate reductase (quinol)
succinate + a quinone = fumarate + a quinol
BR49374 show the reaction diagram
R02164 show the reaction diagram
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: electron transport complex II
natural substrates, multi-step reaction
citrate (Si)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
homocitrate synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
citrate synthase (unknown stereospecificity)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
citrate (Re)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16)
: Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].
natural substrates
citrate CoA-transferase
acetyl-CoA + citrate = acetate + (3S)-citryl-CoA
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natural substrates
succinate + FAD = fumarate + FADH2
R00408 show the reaction diagram
865
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natural substrates
succinate dehydrogenase
succinate + FAD = fumarate + FADH2
R00408 show the reaction diagram
865
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natural substrates
citryl-CoA lyase
(3S)-citryl-CoA = acetyl-CoA + oxaloacetate
BR3376 show the reaction diagram
R00354 show the reaction diagram
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: a part of multi-step reaction (see R00352, R01322+R00354)
natural substrates
succinyl-CoA:acetate CoA-transferase
succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA
R00410 show the reaction diagram
RXNI-2 show the reaction diagram
867
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natural substrates
3-oxoacid CoA-transferase
succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA
R00410 show the reaction diagram
RXNI-2 show the reaction diagram
867
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natural substrates
ATP citrate synthase
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
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: multi-step reaction (see R01322+R00354)
natural substrates, multi-step reaction
malate dehydrogenase (quinone)
(S)-malate + a quinone = oxaloacetate + reduced quinone
R00361 show the reaction diagram
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natural substrates
malate dehydrogenase (quinone)
(S)-malate + acceptor = oxaloacetate + reduced acceptor
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natural substrates, generic
succinate-CoA ligase (GDP-forming)
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA
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natural substrates
citrate-CoA ligase
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
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: a part of multi-step reaction (see R00352, R01322+R00354)
natural substrates