sphingosine N-acyltransferase
Pathways
ceramide biosynthesis (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
acyl-CoA + sphinganine = N-acylsphinganine + CoA
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natural substrates, generic
sphingoid base N-palmitoyltransferase
acyl-CoA + sphinganine = N-acylsphinganine + CoA
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natural substrates, generic
very-long-chain ceramide synthase
acyl-CoA + sphinganine = N-acylsphinganine + CoA
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natural substrates, generic
ultra-long-chain ceramide synthase
acyl-CoA + sphinganine = N-acylsphinganine + CoA
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natural substrates, generic
sphingoid base N-stearoyltransferase
acyl-CoA + sphinganine = N-acylsphinganine + CoA
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natural substrates, generic
serine C-palmitoyltransferase
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2
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natural substrates
sphingolipid 4-desaturase
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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natural substrates, generic, protein
3-dehydrosphinganine reductase
sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+
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natural substrates
4-coumarate-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis IV,
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
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: general reaction
natural substrates
long-chain-fatty-acid-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis IV,
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
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: general reaction
natural substrates
phenylacetate-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis IV,
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
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: general reaction
natural substrates
OPC-8:CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis IV,
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
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: general reaction
natural substrates
firefly luciferase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis IV,
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
stearate biosynthesis II (bacteria and plants),
alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
palmitate biosynthesis III,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (type II fatty acid synthase)
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: general reaction
natural substrates