Pathways
aspartate and asparagine metabolism (BRENDA)






EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
2-oxosuccinamate + H2O = 2-oxosuccinate + NH3
-
-
-
-
natural substrates
omega-amidase
2-oxosuccinamate + H2O = 2-oxosuccinate + NH3
-
-
-
-
natural substrates
tryptophanyl aminopeptidase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
beta-aspartyl-peptidase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
asparaginase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
aryl-acylamidase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
glutaminase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
N4-(beta-N-acetylglucosaminyl)-L-asparaginase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
omega-amidase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
glutamin-(asparagin-)ase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
cyanoalanine nitrilase
L-asparagine + H2O = L-aspartate + NH3
-
-
-
-
natural substrates
asparagine synthase (glutamine-hydrolysing)
ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate
-
-
-

natural substrates
aspartate-ammonia ligase
ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
-
-
-

natural substrates, multi-step reaction
asparagine synthase (glutamine-hydrolysing)
ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
-
-
-

natural substrates, multi-step reaction
aspartate transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
4-aminobutyrate-2-oxoglutarate transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
alanine transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
branched-chain-amino-acid transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
tyrosine transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
cysteine-conjugate transaminase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
aspartate-prephenate aminotransferase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
glutamate-prephenate aminotransferase
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Alanine, aspartate and glutamate metabolism,
Carbon fixation in photosynthetic organisms,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids

C4 photosynthetic carbon assimilation cycle, NAD-ME type,
L-aspartate degradation I,
L-asparagine degradation III (mammalian),
anaerobic energy metabolism (invertebrates, cytosol),
partial TCA cycle (obligate autotrophs),
L-aspartate biosynthesis,
L-glutamate degradation II,
malate/L-aspartate shuttle pathway
-
-
-
-
natural substrates
aspartate-tRNA ligase
ATP + L-aspartate + tRNAAsx = AMP + diphosphate + L-aspartyl-tRNAAsx
-
-
-
-
natural substrates, nucleotide
aspartate-tRNAAsn ligase
ATP + L-aspartate + tRNAAsx = AMP + diphosphate + L-aspartyl-tRNAAsx
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-
-
-
natural substrates, nucleotide
aspartate-tRNA ligase
ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn
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-
-
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natural substrates, nucleotide
asparagine-tRNA ligase
ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn
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-
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natural substrates, nucleotide