Pathways

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BRENDA KEGG MetaCyc

arachidonate biosynthesis (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
long-chain-fatty-acid-CoA ligase
ATP + dihomo-gamma-linolenate + CoA = AMP + diphosphate + dihomo-gamma-linolenoyl-CoA
incomplete
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C21O15S1N7P3H34
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-
very-long-chain enoyl-CoA reductase
a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H = a very-long-chain acyl-CoA + NADP+
generic compounds
-
-
-
natural substrates, generic
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Very-long-chain (3R)-3-hydroxyacyl-CoA <=> Very-long-chain trans-2,3-dehydroacyl-CoA + H2O
BR50205 show the reaction diagram
R10827 show the reaction diagram
-
-
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: Elongation of C16/C18 acyl-CoAs to very-long-chain acyl CoAs.
natural substrates, generic
oleoyl-[acyl-carrier-protein] hydrolase
an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate
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-
-
-
natural substrates, generic, protein
palmitoyl-CoA hydrolase
an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate
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-
-
-
natural substrates, generic, protein
acyl-CoA hydrolase
an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate
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-
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-
natural substrates, generic, protein
dodecanoyl-[acyl-carrier-protein] hydrolase
an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate
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-
-
-
natural substrates, generic, protein
4-coumarate-CoA ligase
ATP + oleate + CoA = AMP + diphosphate + oleoyl-CoA
-
-
-
-
natural substrates
long-chain-fatty-acid-CoA ligase
ATP + oleate + CoA = AMP + diphosphate + oleoyl-CoA
-
-
-
-
natural substrates
OPC-8:CoA ligase
ATP + oleate + CoA = AMP + diphosphate + oleoyl-CoA
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-
-
-
natural substrates
firefly luciferase
ATP + oleate + CoA = AMP + diphosphate + oleoyl-CoA
-
-
-
-
natural substrates
acyl-lipid (8-3)-desaturase
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+ = arachidonic acid + ferricytochrome b5 + H2O
incomplete
-
O1H1
-
natural substrates
acyl-CoA (8-3)-desaturase
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+ = arachidonic acid + ferricytochrome b5 + H2O
incomplete
-
O1H1
-
natural substrates
oleoyl-[acyl-carrier-protein] hydrolase
hexadecanoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + hexadecanoate
-
-
-
: the last step (thioester-hydrolysing) of fatty-acid synthase (ec 2.3.1.85, see R05188, map00061); general reaction
natural substrates, generic, protein
dodecanoyl-[acyl-carrier-protein] hydrolase
hexadecanoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + hexadecanoate
-
-
-
: the last step (thioester-hydrolysing) of fatty-acid synthase (ec 2.3.1.85, see R05188, map00061); general reaction
natural substrates, generic, protein
fatty-acid synthase system
hexadecanoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + hexadecanoate
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-
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: the last step (thioester-hydrolysing) of fatty-acid synthase (ec 2.3.1.85, see R05188, map00061); general reaction
natural substrates, generic, protein
beta-ketoacyl-[acyl-carrier-protein] synthase I
palmitoyl-[acyl-carrier protein] + malonyl-CoA = 3-oxostearoyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
-
natural substrates
sn-1 linoleoyl-lipid 6-desaturase
a 1-linoleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-gamma-linolenoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
generic compounds
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-
-
natural substrates, generic, protein
sn-1 oleoyl-lipid 12-desaturase
a 1-oleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-linoleoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
generic compounds
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-
-
natural substrates, generic, protein
acyl-CoA (9+3)-desaturase
a 1-oleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-linoleoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
generic compounds
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natural substrates, generic, protein