3-oxoadipate CoA-transferase
Pathways
aerobic toluene degradation (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA
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natural substrates
4-carboxymuconolactone decarboxylase
(R)-2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2
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natural substrates
3-carboxy-cis,cis-muconate cycloisomerase
cis,cis-butadiene-1,2,4-tricarboxylate = 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
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natural substrates
Carboxy-cis,cis-muconate cyclase
cis,cis-butadiene-1,2,4-tricarboxylate = 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
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natural substrates
protocatechuate 3,4-dioxygenase
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate
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natural substrates
4-hydroxybenzoate 3-monooxygenase
4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O
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: NADH (ec 1.14.13.33, see R1296)
natural substrates
4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O
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: NADH (ec 1.14.13.33, see R1296)
natural substrates
aldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
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natural substrates
aldehyde dehydrogenase [NAD(P)+]
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
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natural substrates
vanillin dehydrogenase
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
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natural substrates
benzaldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
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natural substrates
4-hydroxybenzaldehyde dehydrogenase (NADP+)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
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natural substrates
4-methylphenol dehydrogenase (hydroxylating)
4-hydroxybenzyl alcohol + 2 oxidized azurin = 4-hydroxybenzaldehyde + 2 reduced azurin + 2 H+
generic compounds
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: the second step of two-step reaction (see R02675, R12133+R12134)
natural substrates, generic
4-hydroxybenzyl alcohol + 2 oxidized azurin = 4-hydroxybenzaldehyde + 2 reduced azurin + 2 H+
generic compounds
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: the second step of two-step reaction (see R02675, R12133+R12134)
natural substrates, generic
acetaldehyde dehydrogenase (acetylating)
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+
: aerobic toluene degradation,
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
: Phenylalanine metabolism,
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: 2-hydroxypenta-2,4-dienoate degradation,
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
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natural substrates
hexadecanal dehydrogenase (acylating)
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+
: aerobic toluene degradation,
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
: Phenylalanine metabolism,
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: 2-hydroxypenta-2,4-dienoate degradation,
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
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natural substrates
butanal dehydrogenase
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+
: aerobic toluene degradation,
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
: Phenylalanine metabolism,
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: 2-hydroxypenta-2,4-dienoate degradation,
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
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natural substrates
propanal dehydrogenase (CoA-propanoylating)
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+
: aerobic toluene degradation,
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
3-phenylpropionate degradation,
threonine metabolism,
ethanol fermentation
: Phenylalanine metabolism,
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
Benzoate degradation,
Pyruvate metabolism,
Dioxin degradation,
Xylene degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
: 2-hydroxypenta-2,4-dienoate degradation,
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
sulfoacetaldehyde degradation IV,
2-deoxy-D-ribose degradation I,
L-threonine degradation IV,
ethanolamine utilization,
heterolactic fermentation,
triethylamine degradation,
2-deoxy-alpha-D-ribose 1-phosphate degradation,
superpathway of fermentation (Chlamydomonas reinhardtii),
pyruvate fermentation to ethanol III,
mixed acid fermentation,
acetylene degradation (anaerobic),
pyruvate fermentation to ethanol I,
2-aminoethylphosphonate degradation I,
ethanol degradation I
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natural substrates
4-hydroxy-2-oxovalerate aldolase
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
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natural substrates
4-hydroxy-2-oxohexanoate aldolase
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
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natural substrates
2-oxopent-4-enoate hydratase
(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O
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natural substrates
2-oxopent-4-enoate hydratase
4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O
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natural substrates
2-hydroxymuconate-6-semialdehyde hydrolase
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate
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natural substrates
2-oxo-3-hexenedioate decarboxylase
(3E)-2-oxohex-3-enedioate = 2-oxopent-4-enoate + CO2
: BR338
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natural substrates
2-hydroxymuconate tautomerase
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
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natural substrates
5.3.2.M1
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
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natural substrates
toluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
generic compounds
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: Oxidized ferredoxin is re-reduced by NADH (see R05875)
natural substrates, generic, protein
toluene methyl-monooxygenase
toluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
generic compounds
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: Oxidized ferredoxin is re-reduced by NADH (see R05875)
natural substrates, generic, protein
aminobutyraldehyde dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
succinate-semialdehyde dehydrogenase (NAD+)
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
benzaldehyde dehydrogenase (NAD+)
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
aryl-aldehyde dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
aldehyde dehydrogenase (NAD+)
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
L-aminoadipate-semialdehyde dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
retinal dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
long-chain-aldehyde dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
aldehyde dehydrogenase [NAD(P)+]
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
4-hydroxybenzaldehyde dehydrogenase (NAD+)
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
salicylaldehyde dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
vanillin dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
fluoroacetaldehyde dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
aldehyde ferredoxin oxidoreductase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
alcohol dehydrogenase
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+
: 1606
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: general reaction
natural substrates
benzoate 1,2-dioxygenase
benzoate + NADH + H+ + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+
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: BenA,BenB,BenC
natural substrates
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+
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: BenD
natural substrates
3-carboxyethylcatechol 2,3-dioxygenase
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
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natural substrates
catechol 2,3-dioxygenase
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
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natural substrates
chloridazon-catechol dioxygenase
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
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natural substrates
hydroxyquinol 1,2-dioxygenase
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
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natural substrates
biphenyl-2,3-diol 1,2-dioxygenase
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
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natural substrates
aminomuconate-semialdehyde dehydrogenase
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+
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natural substrates
2-hydroxymuconate-6-semialdehyde dehydrogenase
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+
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natural substrates
toluene 2-monooxygenase
toluene + NADH + H+ + O2 = 2-methylphenol + NAD+ + H2O
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natural substrates
toluene 4-monooxygenase
2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O
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natural substrates
toluene 2-monooxygenase
2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O
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natural substrates
2-hydroxybiphenyl 3-monooxygenase
2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O
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natural substrates
phenol 2-monooxygenase (NADPH)
2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O
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natural substrates
toluene dioxygenase
toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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natural substrates
3-methylcatechol + O2 = 2-hydroxy-6-oxohepta-2,4-dienoate
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natural substrates
3-carboxyethylcatechol 2,3-dioxygenase
3-methylcatechol + O2 = 2-hydroxy-6-oxohepta-2,4-dienoate
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natural substrates
catechol 2,3-dioxygenase
3-methylcatechol + O2 = 2-hydroxy-6-oxohepta-2,4-dienoate
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natural substrates
biphenyl-2,3-diol 1,2-dioxygenase
3-methylcatechol + O2 = 2-hydroxy-6-oxohepta-2,4-dienoate
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natural substrates
1,2-dihydroxynaphthalene dioxygenase
3-methylcatechol + O2 = 2-hydroxy-6-oxohepta-2,4-dienoate
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natural substrates
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate
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natural substrates
toluene 4-monooxygenase
toluene + NADH + H+ + O2 = 4-methylphenol + NAD+ + H2O
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natural substrates
4-methylphenol + 2 oxidized azurin + H2O = 4-hydroxybenzyl alcohol + 2 reduced azurin + 2 H+
generic compounds
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: the first step of two-step reaction (see R02675, R12133+R12134)
natural substrates, generic
4-methylphenol dehydrogenase (hydroxylating)
4-methylphenol + 2 oxidized azurin + H2O = 4-hydroxybenzyl alcohol + 2 reduced azurin + 2 H+
generic compounds
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: the first step of two-step reaction (see R02675, R12133+R12134)
natural substrates, generic