Pathways

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BRENDA KEGG MetaCyc

NAD metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
NAD+ diphosphatase
nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage (plants),
NAD salvage pathway III (to nicotinamide riboside)
: BS392887show the reaction diagram
: R02323show the reaction diagram
: RXN-5841show the reaction diagram
-
-
-
-
natural substrates, nucleotide
UDP-sugar diphosphatase
nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage (plants),
NAD salvage pathway III (to nicotinamide riboside)
: BS392887show the reaction diagram
: R02323show the reaction diagram
: RXN-5841show the reaction diagram
-
-
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-
natural substrates, nucleotide
nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage (plants),
NAD salvage pathway III (to nicotinamide riboside)
: BS392887show the reaction diagram
: R02323show the reaction diagram
: RXN-5841show the reaction diagram
-
-
-
-
natural substrates, nucleotide
acid phosphatase
nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage (plants),
NAD salvage pathway III (to nicotinamide riboside)
: BS392887show the reaction diagram
: R02323show the reaction diagram
: RXN-5841show the reaction diagram
-
-
-
-
natural substrates, nucleotide
5'-nucleotidase
nicotinamide mononucleotide + H2O = nicotinamide riboside + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage (plants),
NAD salvage pathway III (to nicotinamide riboside)
: BS392887show the reaction diagram
: R02323show the reaction diagram
: RXN-5841show the reaction diagram
-
-
-
-
natural substrates, nucleotide
nicotinate phosphoribosyltransferase
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD salvage (plants),
NAD salvage pathway I (PNC VI cycle),
NAD salvage pathway V (PNC V cycle)
: BR47484show the reaction diagram
: R01724show the reaction diagram
: NICOTINATEPRIBOSYLTRANS-RXNshow the reaction diagram
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-
-
-
natural substrates, nucleotide
nicotinamide-nucleotide amidase
beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage pathway II (PNC IV cycle)
: BR22692show the reaction diagram
: R02322show the reaction diagram
: NMNAMIDOHYDRO-RXNshow the reaction diagram
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-
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-
natural substrates, nucleotide
ribosylnicotinamide kinase
ATP + nicotinamide ribonucleotide = diphosphate + NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage pathway IV (from nicotinamide riboside),
NAD biosynthesis from nicotinamide
: BR47858show the reaction diagram
: R00137show the reaction diagram
: 2.7.7.1-RXNshow the reaction diagram
: 706
-
-
-
-
natural substrates
nicotinamide-nucleotide adenylyltransferase
ATP + nicotinamide ribonucleotide = diphosphate + NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage pathway IV (from nicotinamide riboside),
NAD biosynthesis from nicotinamide
: BR47858show the reaction diagram
: R00137show the reaction diagram
: 2.7.7.1-RXNshow the reaction diagram
: 706
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natural substrates
nicotinate-nucleotide adenylyltransferase
ATP + nicotinamide ribonucleotide = diphosphate + NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD salvage pathway IV (from nicotinamide riboside),
NAD biosynthesis from nicotinamide
: BR47858show the reaction diagram
: R00137show the reaction diagram
: 2.7.7.1-RXNshow the reaction diagram
: 706
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-
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-
natural substrates
NAD+ glycohydrolase
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: BR16043show the reaction diagram
: R00102show the reaction diagram
: NADNUCLEOSID-RXNshow the reaction diagram, RXN-13859show the reaction diagram
: 683
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-
natural substrates
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: BR16043show the reaction diagram
: R00102show the reaction diagram
: NADNUCLEOSID-RXNshow the reaction diagram, RXN-13859show the reaction diagram
: 683
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-
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natural substrates
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: BR16043show the reaction diagram
: R00102show the reaction diagram
: NADNUCLEOSID-RXNshow the reaction diagram, RXN-13859show the reaction diagram
: 683
-
-
-
-
natural substrates
NAD+ ADP-ribosyltransferase
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: BR16043show the reaction diagram
: R00102show the reaction diagram
: NADNUCLEOSID-RXNshow the reaction diagram, RXN-13859show the reaction diagram
: 683
-
-
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-
natural substrates
NMN nucleosidase
beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide
: NAD metabolism
: Nicotinate and nicotinamide metabolism
: NAD salvage (plants),
NAD salvage pathway I (PNC VI cycle)
: BR19226show the reaction diagram
: R01270show the reaction diagram
: NMNNUCLEOSID-RXNshow the reaction diagram
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natural substrates, nucleotide
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide
: NAD metabolism
: Nicotinate and nicotinamide metabolism
: NAD salvage (plants),
NAD salvage pathway I (PNC VI cycle)
: BR19226show the reaction diagram
: R01270show the reaction diagram
: NMNNUCLEOSID-RXNshow the reaction diagram
-
-
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-
natural substrates, nucleotide
aryl-acylamidase
nicotinamide + H2O = nicotinate + NH3
: degradation of aromatic, nitrogen containing compounds,
NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD salvage (plants),
NAD salvage pathway I (PNC VI cycle),
NAD salvage pathway V (PNC V cycle),
aldoxime degradation
: BR26099show the reaction diagram
: R01268show the reaction diagram
: NICOTINAMID-RXNshow the reaction diagram
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natural substrates
nicotinamidase
nicotinamide + H2O = nicotinate + NH3
: degradation of aromatic, nitrogen containing compounds,
NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD salvage (plants),
NAD salvage pathway I (PNC VI cycle),
NAD salvage pathway V (PNC V cycle),
aldoxime degradation
: BR26099show the reaction diagram
: R01268show the reaction diagram
: NICOTINAMID-RXNshow the reaction diagram
-
-
-
-
natural substrates
amidase
nicotinamide + H2O = nicotinate + NH3
: degradation of aromatic, nitrogen containing compounds,
NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD salvage (plants),
NAD salvage pathway I (PNC VI cycle),
NAD salvage pathway V (PNC V cycle),
aldoxime degradation
: BR26099show the reaction diagram
: R01268show the reaction diagram
: NICOTINAMID-RXNshow the reaction diagram
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natural substrates
FAD diphosphatase
NAD(H) + H2O = AMP + NMN(H)
: NAD metabolism
: BR22763show the reaction diagram
: R11104show the reaction diagram
: RXN0-4401show the reaction diagram
: 10186
-
-
-
-
natural substrates
NAD+ diphosphatase
NAD(H) + H2O = AMP + NMN(H)
: NAD metabolism
: BR22763show the reaction diagram
: R11104show the reaction diagram
: RXN0-4401show the reaction diagram
: 10186
-
-
-
-
natural substrates
UDP-sugar diphosphatase
NAD(H) + H2O = AMP + NMN(H)
: NAD metabolism
: BR22763show the reaction diagram
: R11104show the reaction diagram
: RXN0-4401show the reaction diagram
: 10186
-
-
-
-
natural substrates
8-oxo-dGTP diphosphatase
NAD(H) + H2O = AMP + NMN(H)
: NAD metabolism
: BR22763show the reaction diagram
: R11104show the reaction diagram
: RXN0-4401show the reaction diagram
: 10186
-
-
-
-
natural substrates
nucleotide diphosphatase
NAD(H) + H2O = AMP + NMN(H)
: NAD metabolism
: BR22763show the reaction diagram
: R11104show the reaction diagram
: RXN0-4401show the reaction diagram
: 10186
-
-
-
-
natural substrates
NAD+ kinase
ATP + NAD+ = ADP + NADP+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NADP biosynthesis,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation,
mitochondrial NADPH production (yeast),
cytosolic NADPH production (yeast),
NAD(P)/NADPH interconversion
: BR47763show the reaction diagram, BR53427show the reaction diagram
: R00104show the reaction diagram, R12980show the reaction diagram
: NAD-KIN-RXNshow the reaction diagram, RXN-22703show the reaction diagram
: 47
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natural substrates
NAD+ 3'-kinase
ATP + NAD+ = ADP + NADP+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NADP biosynthesis,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation,
mitochondrial NADPH production (yeast),
cytosolic NADPH production (yeast),
NAD(P)/NADPH interconversion
: BR47763show the reaction diagram, BR53427show the reaction diagram
: R00104show the reaction diagram, R12980show the reaction diagram
: NAD-KIN-RXNshow the reaction diagram, RXN-22703show the reaction diagram
: 47
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natural substrates
2.7.1.M29
ATP + NAD+ = ADP + NADP+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NADP biosynthesis,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation,
mitochondrial NADPH production (yeast),
cytosolic NADPH production (yeast),
NAD(P)/NADPH interconversion
: BR47763show the reaction diagram, BR53427show the reaction diagram
: R00104show the reaction diagram, R12980show the reaction diagram
: NAD-KIN-RXNshow the reaction diagram, RXN-22703show the reaction diagram
: 47
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natural substrates
NAD(P)+ transhydrogenase (Si-specific)
NADPH + NAD+ = NADP+ + NADH
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD(P)/NADPH interconversion,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation
: BR36919show the reaction diagram
: R00112show the reaction diagram
: PYRNUTRANSHYDROGEN-RXNshow the reaction diagram, TRANS-RXN0-277show the reaction diagram
: 692
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-
-
: specific for the B-faces of both NADP+ and NAD+ (ec 1.6.1.1) specific for the B-face of NADP+ and the A-face of NAD+ (ec 1.6.1.2)
natural substrates
NAD(P)+ transhydrogenase (Re/Si-specific)
NADPH + NAD+ = NADP+ + NADH
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD(P)/NADPH interconversion,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation
: BR36919show the reaction diagram
: R00112show the reaction diagram
: PYRNUTRANSHYDROGEN-RXNshow the reaction diagram, TRANS-RXN0-277show the reaction diagram
: 692
-
-
-
: specific for the B-faces of both NADP+ and NAD+ (ec 1.6.1.1) specific for the B-face of NADP+ and the A-face of NAD+ (ec 1.6.1.2)
natural substrates
NAD(P)+ transhydrogenase
NADPH + NAD+ = NADP+ + NADH
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD(P)/NADPH interconversion,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation
: BR36919show the reaction diagram
: R00112show the reaction diagram
: PYRNUTRANSHYDROGEN-RXNshow the reaction diagram, TRANS-RXN0-277show the reaction diagram
: 692
-
-
-
: specific for the B-faces of both NADP+ and NAD+ (ec 1.6.1.1) specific for the B-face of NADP+ and the A-face of NAD+ (ec 1.6.1.2)
natural substrates
7.1.1.1
proton-translocating NAD(P)+ transhydrogenase
NADPH + NAD+ = NADP+ + NADH
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways
: NAD(P)/NADPH interconversion,
NAD phosphorylation and dephosphorylation,
NAD phosphorylation and transhydrogenation
: BR36919show the reaction diagram
: R00112show the reaction diagram
: PYRNUTRANSHYDROGEN-RXNshow the reaction diagram, TRANS-RXN0-277show the reaction diagram
: 692
-
-
-
: specific for the B-faces of both NADP+ and NAD+ (ec 1.6.1.1) specific for the B-face of NADP+ and the A-face of NAD+ (ec 1.6.1.2)
natural substrates
NAD+ synthase
ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD salvage pathway II (PNC IV cycle),
NAD salvage pathway I (PNC VI cycle),
NAD de novo biosynthesis I
: BR96show the reaction diagram
: R00189show the reaction diagram
: NAD-SYNTH-NH3-RXNshow the reaction diagram
: 13688
-
-
-
-
natural substrates
NAD+ synthase (glutamine-hydrolysing)
ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD salvage pathway II (PNC IV cycle),
NAD salvage pathway I (PNC VI cycle),
NAD de novo biosynthesis I
: BR96show the reaction diagram
: R00189show the reaction diagram
: NAD-SYNTH-NH3-RXNshow the reaction diagram
: 13688
-
-
-
-
natural substrates
nicotinamide-nucleotide adenylyltransferase
ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD salvage (plants),
NAD salvage pathway II (PNC IV cycle),
NAD salvage pathway I (PNC VI cycle),
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde,
NAD salvage pathway V (PNC V cycle),
NAD de novo biosynthesis I
: BR47865show the reaction diagram
: R03005show the reaction diagram
: NICONUCADENYLYLTRAN-RXNshow the reaction diagram
: 11646, 2857
-
-
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natural substrates
nicotinate-nucleotide adenylyltransferase
ATP + beta-nicotinate D-ribonucleotide = diphosphate + deamido-NAD+
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD salvage (plants),
NAD salvage pathway II (PNC IV cycle),
NAD salvage pathway I (PNC VI cycle),
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde,
NAD salvage pathway V (PNC V cycle),
NAD de novo biosynthesis I
: BR47865show the reaction diagram
: R03005show the reaction diagram
: NICONUCADENYLYLTRAN-RXNshow the reaction diagram
: 11646, 2857
-
-
-
-
natural substrates
NAD+ synthase
ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD salvage (plants),
NAD salvage pathway II (PNC IV cycle),
NAD salvage pathway I (PNC VI cycle),
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde,
NAD salvage pathway V (PNC V cycle),
NAD de novo biosynthesis I
: BR147show the reaction diagram
: R00257show the reaction diagram
: NAD-SYNTH-GLN-RXNshow the reaction diagram
-
-
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-
natural substrates, nucleotide
NAD+ synthase (glutamine-hydrolysing)
ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD salvage (plants),
NAD salvage pathway II (PNC IV cycle),
NAD salvage pathway I (PNC VI cycle),
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde,
NAD salvage pathway V (PNC V cycle),
NAD de novo biosynthesis I
: BR147show the reaction diagram
: R00257show the reaction diagram
: NAD-SYNTH-GLN-RXNshow the reaction diagram
-
-
-
-
natural substrates, nucleotide
quinolinate synthase
glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
nicotine biosynthesis,
superpathway of nicotine biosynthesis,
NAD de novo biosynthesis I
: BR48966show the reaction diagram
: R04292show the reaction diagram
: QUINOLINATE-SYNTHA-RXNshow the reaction diagram
-
-
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-
natural substrates
nicotinate-nucleotide diphosphorylase (carboxylating)
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: NAD de novo biosynthesis III,
NAD de novo biosynthesis IV (anaerobic),
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde,
nicotine biosynthesis,
superpathway of nicotine biosynthesis,
NAD de novo biosynthesis I
: BR47506show the reaction diagram
: R03348show the reaction diagram
: QUINOPRIBOTRANS-RXNshow the reaction diagram
: 3155
-
-
-
-
natural substrates
L-aspartate oxidase
L-aspartate + O2 = iminosuccinate + H2O2
: NAD metabolism
: Nicotinate and nicotinamide metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: nicotine biosynthesis,
superpathway of nicotine biosynthesis,
NAD de novo biosynthesis I
: BR36878show the reaction diagram, BS441340show the reaction diagram
: R00481show the reaction diagram
: L-ASPARTATE-OXID-RXNshow the reaction diagram
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-
-
: iminoaspartate can either be hydrolysed (see R00357) or can be used by ec 2.5.1.72 (see R04292)
natural substrates
NAD+ ADP-ribosyltransferase
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
: NAD metabolism
: BR47504show the reaction diagram
: R04176show the reaction diagram
: NAD+-ADP-RIBOSYLTRANSFERASE-RXNshow the reaction diagram
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-
-
-
natural substrates, generic
NAD+-protein-arginine ADP-ribosyltransferase
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
: NAD metabolism
: BR47504show the reaction diagram
: R04176show the reaction diagram
: NAD+-ADP-RIBOSYLTRANSFERASE-RXNshow the reaction diagram
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-
-
-
natural substrates, generic