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Pathways

4-hydroxymandelate degradation (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

1.2.1.4

aldehyde dehydrogenase (NADP+)

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments

: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR51337

: R01294

: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN

, RXN-13394

: 1509

natural substrates

1.2.1.5

aldehyde dehydrogenase [NAD(P)+]

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments

: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR51337

: R01294

: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN

, RXN-13394

: 1509

natural substrates

1.2.1.67

vanillin dehydrogenase

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments

: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR51337

: R01294

: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN

, RXN-13394

: 1509

natural substrates

1.2.1.7

benzaldehyde dehydrogenase (NADP+)

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments

: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR51337

: R01294

: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN

, RXN-13394

: 1509

natural substrates

1.2.1.96

4-hydroxybenzaldehyde dehydrogenase (NADP+)

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Microbial metabolism in diverse environments

: 4-methylphenol degradation to protocatechuate,
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR51337

: R01294

: HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN

, RXN-13394

: 1509

natural substrates

1.2.1.28

benzaldehyde dehydrogenase (NAD+)

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

1.2.1.29

aryl-aldehyde dehydrogenase

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

1.2.1.3

aldehyde dehydrogenase (NAD+)

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

1.2.1.64

4-hydroxybenzaldehyde dehydrogenase (NAD+)

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

1.2.1.65

salicylaldehyde dehydrogenase

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

1.2.1.67

vanillin dehydrogenase

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

1.2.1.96

4-hydroxybenzaldehyde dehydrogenase (NADP+)

4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+

: 4-hydroxymandelate degradation

: Toluene degradation,
Aminobenzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 4-hydroxybenzoate biosynthesis I (eukaryotes),
4-hydroxybenzoate biosynthesis IV (plants),
4-hydroxymandelate degradation,
4-coumarate degradation (aerobic),
4-coumarate degradation (anaerobic)

: BR29420

: R01293

: HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN

, RXN-13394_WOP

: 1508

natural substrates

5.1.2.2

mandelate racemase

p-hydroxy-D-mandelate = p-hydroxy-L-mandelate

: 4-hydroxymandelate degradation

: Microbial metabolism in diverse environments

: 4-hydroxymandelate degradation

: BS186625

: R04161

: HYDROXY-MANDELATE-RACEMASE-RXN

natural substrates

1.14.13.2

4-hydroxybenzoate 3-monooxygenase

4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: 4-coumarate degradation (aerobic),
polybrominated dihydroxylated diphenyl ethers biosynthesis,
spongiadioxin C biosynthesis,
bisphenol A degradation,
4-methylphenol degradation to protocatechuate,
4-chlorobenzoate degradation,
4-hydroxymandelate degradation

: BR36759

: R01298

: 1.14.13.33-RXN

, 4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN

: NADH (ec 1.14.13.33, see R1296)

natural substrates

1.14.13.33

4-hydroxybenzoate 3-monooxygenase [NAD(P)H]

4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: BR36759

: R01298

: 1.14.13.33-RXN

, 4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN

: NADH (ec 1.14.13.33, see R1296)

natural substrates

1.13.11.3

protocatechuate 3,4-dioxygenase

3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate

: 4-hydroxymandelate degradation

: Benzoate degradation,
Polycyclic aromatic hydrocarbon degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: protocatechuate degradation II (ortho-cleavage pathway)

: BR40477

: R01631

: PROTOCATECHUATE-34-DIOXYGENASE-RXN

natural substrates

4.1.1.44

4-carboxymuconolactone decarboxylase

(R)-2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: protocatechuate degradation II (ortho-cleavage pathway)

: BR3361

, BS18492

: R03470

: 4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN

natural substrates

5.5.1.2

3-Carboxy-cis,cis-muconate cycloisomerase

2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: protocatechuate degradation II (ortho-cleavage pathway)

: BR260

, BR263

: R03307

, R03308

: 5.5.1.2-RXN

, CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN

: 3123

natural substrates

5.5.1.5

Carboxy-cis,cis-muconate cyclase

2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: protocatechuate degradation II (ortho-cleavage pathway)

: BR260

, BR263

: R03307

, R03308

: 5.5.1.2-RXN

, CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN

: 3123

natural substrates

3.1.1.24

3-oxoadipate enol-lactonase

3-oxoadipate enol-lactone + H2O = 3-oxoadipate

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds

: protocatechuate degradation II (ortho-cleavage pathway),
catechol degradation to beta-ketoadipate

: BR11711

: R02991

: 3-OXOADIPATE-ENOL-LACTONASE-RXN

natural substrates

2.8.3.6

3-oxoadipate CoA-transferase

succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA

: 4-hydroxymandelate degradation

: Benzoate degradation,
Metabolic pathways,
Microbial metabolism in diverse environments

: 3-oxoadipate degradation

: BR48131

: R02990

: 3-OXOADIPATE-COA-TRANSFERASE-RXN

: 2842

natural substrates